Key takeaways
Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) and Truvada (emtricitabine/tenofovir disoproxil fumarate) are both used to treat HIV, but they have some key differences. Atripla is a single-tablet regimen that includes three antiretrovirals: efavirenz, emtricitabine, and tenofovir. It is taken once daily on an empty stomach, preferably at bedtime to avoid side effects like dizziness and abnormal dreams. Truvada, on the other hand, contains only two antiretrovirals: emtricitabine and tenofovir, and is also taken once daily but can be taken with or without food. Truvada is not a complete treatment for HIV and must be combined with another medication, but it is also approved for HIV PrEP (pre-exposure prophylaxis) to prevent HIV infection. Atripla is no longer a first-choice treatment due to its side effects, while Truvada is preferred for both treatment and prevention. Both medications can cause kidney and bone problems. Additionally, both medications are available as generics.
