Key takeaways
Atripla (efavirenz/emtricitabine/tenofovir) and Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir) are both single-tablet regimens used to treat HIV, but they have some key differences. Atripla contains a non-nucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs), while Stribild includes an integrase inhibitor, two NRTIs, and a booster medication. Atripla should be taken on an empty stomach, preferably at bedtime to avoid side effects like dizziness and abnormal dreams, whereas Stribild must be taken with food to improve absorption and reduce stomach upset. Atripla is available as a generic, making it more affordable, while Stribild is not. Both medications can cause kidney and bone problems, but Stribild is noted for fewer abnormal dreams compared to Atripla. Neither medication is recommended for people with significant liver or kidney issues, and both have interactions with many other medications.
