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Arthrotec vs. Ibuprofen

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Arthrotec (diclofenac/misoprostol) and ibuprofen are both used to relieve pain and inflammation, but they have some key differences. Arthrotec is a combination of diclofenac, a non-steroidal anti-inflammatory drug (NSAID), and misoprostol, a prostaglandin that protects the stomach from ulcers caused by NSAIDs. This makes arthrotec particularly useful for non-pregnant adults with arthritis who are at high risk for stomach and intestinal ulcers. On the other hand, ibuprofen is an NSAID available both over-the-counter (/otc) and by prescription, used for a wide range of minor aches, pains, and fever. While both medications can cause serious side effects like stomach bleeding and heart problems, people who are pregnant shouldn't take arthrotec due to the misoprostol component. Additionally, arthrotec requires multiple doses throughout the day, while ibuprofen's dosing depends on the condition being treated. Both medications should not be taken together or with other NSAIDs to avoid increased risk of side effects.

Arthrotec

(diclofenac / misoprostol)

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Ibuprofen

 

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Summary for Arthrotec

Prescription only

Arthrotec (diclofenac / misoprostol) is a combination medication used to treat osteoarthritis (OA) and rheumatoid arthritis (RA) in non-pregnant adults. The diclofenac in Arthrotec is a non-steroidal anti-inflammatory drug (NSAID) that helps with pain and swelling, while the misoprostol is a prostaglandin E1 analog that lowers the risk of stomach and intestinal ulcers from diclofenac. Arthrotec (diclofenac / misoprostol) is taken by mouth, typically two to four times per day. Common side effects of this medication include stomach cramps (pain) and diarrhea. Avoid drinking alcohol with Arthrotec (diclofenac / misoprostol) because doing so can raise the risk of stomach bleeding.

Indications for Arthrotec

Pros and Cons for Arthrotec

Pros

  • Diclofenac works well to relieve symptoms of pain and swelling and misoprostol works well to lower the risk of stomach and intestinal ulcers and bleeding
  • Conveniently combines two medication in one pill
  • Available as a lower-cost generic

Cons

  • Needs to be taken multiple times a day
  • Not safe to take at any time of pregnancy
  • Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems

Common Side Effects for Arthrotec

  • Stomach pain (21%)
  • Diarrhea (19%)
  • Upset stomach or indigestion (14%)
  • Nausea (11%)
  • Gas (9%)

Warnings for Arthrotec

  • Harm to mother and unborn baby
  • Stomach bleeding
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions and skin reactions
  • Risk for bleeding

Summary for Ibuprofen

Prescription or over-the-counter

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that's used to temporarily relieve fever, pains, and aches in adults and children. In general, ibuprofen is taken by mouth every 4 to 8 hours, though the dosage depends on your age, weight, and other medical problems. Ibuprofen side effects include nausea, heartburn, and stomach pain, but taking it with food might help prevent these side effects. Ibuprofen is available over the counter and by prescription, depending on the strength you need.

Indications for Ibuprofen

Over-the-counter ibuprofen:

Prescription ibuprofen:

Pros and Cons for Ibuprofen

Pros

  • Works well for fever, pain, and swelling
  • Available over the counter and by prescription and as lower-cost generics
  • Available as tablets, capsules, chewable tablets, and an oral liquid
  • Chewable tablets and liquid can be used in children

Cons

  • Lasts for only about 6 hours, so might need to take multiple doses throughout the day
  • Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems
  • Has risk of stomach bleeding, stomach ulcers, and kidney problems
  • Shouldn't take other NSAIDs at the same time because of higher risk for side effects

Common Side Effects for Ibuprofen

The following side effects were reported in up to 9% of people in clinical studies.

  • Nausea
  • Stomach pain
  • Heartburn
  • Dizziness
  • Rash

Warnings for Ibuprofen

  • Stomach bleeding and ulcers
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions
  • Harm to unborn babies
  • Caution use in people with phenylketonuria (PKU) - chewable tablets only

Prices with our coupons for Arthrotec vs. Ibuprofen

Price Card Drug Icon
Diclofenac Sodium/Misoprostol60 tablets / 75mg/200mcg
$54.72$205.08
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Ibuprofen30 tablets / 800mg
$8.92$16.19
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