Key takeaways
Isotretinoin (brands: Claravis, Absorica, Amnesteem, Myorisan, Zenatane) and Epiduo (adapalene/benzoyl peroxide) are both used to treat acne, but they have some key differences. Isotretinoin is an oral medication typically taken twice daily for 4 to 5 months at a time, while Epiduo is a topical gel applied once daily. Isotretinoin is a retinoic acid derivative that reduces oil production in the skin, whereas Epiduo combines a retinoid (adapalene) and a topical antibiotic (benzoyl peroxide) to stop pimples from forming and kill acne-causing bacteria. Isotretinoin can cause serious birth defects, so people who can get pregnant must follow strict birth control measures and register with the iPLEDGE program. Epiduo, on the other hand, can cause skin irritation but does not have the same severe birth defect risks. Isotretinoin is typically used for severe acne that hasn't responded to other treatments, while Epiduo is used for mild-to-moderate acne.
