Retinoid and lincosamide antibiotic combinations are used to treat acne. These medications work by combining the effects of a retinoid, which helps to unclog pores and reduce inflammation, with a lincosamide antibiotic that fights bacteria. These combinations are typically available in topical forms, such as gels or creams, making them easy to apply directly to the affected area. Examples include clindamycin/tretinoin (Ziana, Veltin).