Skip to main content

Complement Inhibitors

Complement inhibitors are a type of monoclonal antibody that are used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). They prevent a part of the immune system from harming healthy cells and tissue.

Why are complement inhibitors prescribed?

  1. Myasthenia Gravis (17%)
  2. Anemia (17%)
  3. Macular Degeneration (17%)
  4. Neuromyelitis Optica Spectrum Disorder (17%)
  5. Paroxysmal Nocturnal Hemoglobinuria (17%)
  6. ANCA Associated Vasculitis (17%)

Key takeaways

Complement inhibitors are used to treat conditions like paroxysmal nocturnal hemoglobinuria (PNH), myasthenia gravis (MG), and age-related macular degeneration (AMD). These medications work by blocking portions of the complement system, which is a part of your immune system that can cause inflammation and tissue damage when overactive. Complement inhibitors come in different forms, including oral pills and injections. Examples include Fabhalta (iptacopan), Zilbrysq (zilucoplan), and Izervay (avacincaptad pegol).

Prices for popular Complement Inhibitors medications
Viewing 7 of 7 medications
kit icon

Voydeya

as low as$5,493
Voydeya is part of the Complement Inhibitors class and treats Anemia. Complement inhibitors are a type of monoclonal antibody that are used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). They prevent a part of the immune system from harming healthy cells and tissue. Voydeya is only available as a brand name drug.
See prices
capsule icon

Tavneos

as low as$16,637
AVACOPAN treats autoimmune conditions that cause inflammation in the small blood vessels of the body, such as granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It works by slowing down an overactive immune system. This decreases inflammation.
See pricesMore info
vial icon

Izervay

as low as$20,104
AVACINCAPTAD PEGOL treats macular degeneration, a condition that can cause vision loss. It works by helping to slow changes in vision.
See pricesMore info
carton icon

Zilbrysq

as low as$21,460
ZILUCOPLAN treats myasthenia gravis, a condition that causes muscles to easily weaken or fatigue. It works by decreasing muscle weakness and loss of movement.
See pricesMore info
vial icon

Epysqli

Epysqli is part of the Complement Inhibitors class and treats Myasthenia Gravis and Paroxysmal Nocturnal Hemoglobinuria. Complement inhibitors are a type of monoclonal antibody that are used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). They prevent a part of the immune system from harming healthy cells and tissue. Epysqli is only available as a brand name drug.
See prices
capsule icon

Fabhalta

Fabhalta (Iptacopan) is used to treat Paroxysmal Nocturnal Hemoglobinuria (PNH) and Immunoglobulin A Nephropathy (IgAN). Fabhalta is a Complement Inhibitor, which works by slowing down an overactive immune system. Fabhalta is only available as a brand name drug.
See pricesMore info
vial icon

Soliris

ECULIZUMAB treats certain blood conditions that can cause low levels of red blood cells (anemia) and blood clots, such as atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH). It works by slowing down an overactive immune system, which reduces the breakdown of red blood cells. It also prevents blood cells (platelets) from forming a clot. It may also be used to treat a condition that causes muscles to easily weaken or fatigue (myasthenia gravis).
See pricesMore info
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

Subscribe and save

Get prescription saving tips and more from GoodRx Health. Enter your email to sign up

By signing up, I agree to GoodRx’s Terms of Use and Privacy Policy, and to receive marketing messages from GoodRx.

Latest Articles

myasthenia gravis: healthcare professional speaking to patient 2030190156

Zilbrysq vs. Rystiggo: 5 Differences Between These Targeted Myasthenia Gravis Treatments

Rachel Feaster, PharmD, BCOP, BCPSPublished on May 28, 2024
Pharmacy: healthcare professional speaking to patient 1496795538

How Effective Is Zilbrysq for Myasthenia Gravis? Plus, 5 Other Zilbrysq FAQs

Sheila McAdoo, PharmDPublished on May 7, 2024

Browse medications

View All
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.
ABCDEFGHIJKLMNOPQRSTUVWXYZ