Enjaymo
Enjaymo (sutimlimab or sutimlimab-jome) is a newly-approved medication used to lower the need for blood transfusions in adults with a rare form of anemia called cold agglutinin disease (CAD). It's given as an infusion into the veins by a healthcare provider.
What is Enjaymo (sutimlimab)?
What is Enjaymo (sutimlimab) used for?
Cold agglutinin disease (CAD)
How Enjaymo (sutimlimab) works
Enjaymo (sutimlimab) is a complement inhibitor. It works by attaching to certain proteins in your immune system. This prevents them from being activated so your immune system can't attack your own red blood cells by mistake, which is what happens in CAD. This helps treat symptoms of CAD.
Drug Facts
What are the side effects of Enjaymo (sutimlimab)?
Common Side Effects
- Respiratory tract infection (25%)
- Viral infection (13%)
- Cough (13%)
- Joint pain (13%)
- Swelling in arms or legs (13%)
- Diarrhea (13%)
- Upset stomach (13%)
Other Side Effects
- Feeling tired
- Headache
- Infusion reaction
- Urinary tract infection (UTI)
- High blood pressure
Serious Side Effects
- Serious infections: fever, difficulty breathing, headache, weakness, confusion, sweating, chills, stiff neck, fast heart rate, muscle aches, diarrhea
- Severe allergic reaction: hives; swelling of the lips, tongue, or face; difficulty breathing; chest pain
- Infusion reaction: shortness of breath, fast heartbeat, flushing, headache, nausea
Source: DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
- Lupus-like syndrome—joint pain, swelling, or stiffness, butterfly-shaped rash on the face, rashes that get worse in the sun, fever, unusual weakness or fatigue
- Raynaud's—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Dizziness
- Headache
- Increase in blood pressure
- Nausea
- Swelling of the ankles, hands, or feet
Pros and cons of Enjaymo (sutimlimab)
Pros
Given every 2 weeks (after the first 2 doses)
Works well to raise hemoglobin levels
Can lower the number of blood transfusions needed in people with CAD
Cons
Needs to be given by a healthcare provider as an IV infusion
Requires monitoring for up to 2 hours after each infusion for allergic reactions
Hasn't been studied in children younger than 18 years old
Pharmacist tips for Enjaymo (sutimlimab)
Mark your appointments on your calendar to help you remember to receive your Enjaymo (sutimlimab) infusions on time and get lab work done when instructed. By doing so, your provider can properly monitor how well Enjaymo (sutimlimab) is working for you and if you're having any side effects.
Try to avoid missing any appointments for your Enjaymo (sutimlimab) infusions so the medication can work the best it can for you. If you happen to miss an infusion, call your provider right away to reschedule.
Bring a book or something to pass the time during your Enjaymo (sutimlimab) infusion appointments since it can take a few hours until you're finished.
Make sure to keep a record of all your immunizations, and show it to your provider before starting Enjaymo (sutimlimab). This is helpful for your provider to see what vaccines you still need before starting treatment. Getting the appropriate vaccines before starting Enjaymo (sutimlimab) can help prevent serious infections from happening while you take the medication.
Don't stop taking Enjaymo (sutimlimab) without speaking with your provider first. If you stop taking Enjaymo (sutimlimab) too suddenly, your symptoms could come back.
Frequently asked questions about Enjaymo (sutimlimab)
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What are the risks and warnings for Enjaymo (sutimlimab)?
Enjaymo (sutimlimab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Serious infections
Enjaymo (sutimlimab) can affect your body's ability to fight off infections. This can raise your risk of serious or life-threatening infections like pneumonia, meningitis (infection of brain and spinal cord), and Hib disease. To lower your risk of infection, you'll need to get the pneumonia (or pneumococcal) vaccine, the meningitis (or meningococcal) vaccine, and the Hib vaccine at least 2 weeks before starting Enjaymo (sutimlimab). Your provider will routinely monitor you for infections before and during treatment. If you get an infection, you might have to stop taking Enjaymo (sutimlimab) so your body can fight it off with proper treatment. Get medical help right away if you have symptoms of an infection such as fever, cough, difficulty breathing, weakness, sweating, chills, or diarrhea while taking Enjaymo (sutimlimab).
Allergic or infusion reactions
Severe allergic reactions to Enjaymo (sutimlimab) are possible, including life-threatening reactions like facial swelling, hives, and anaphylaxis (e.g., closing of the throat). Enjaymo (sutimlimab) can also cause infusion reactions. If you notice dizziness; fast heartbeat; headache; nausea; flushing; swelling around your eyes, lips, or tongue; or difficulty breathing at any time during Enjaymo (sutimlimab) treatment, get medical attention right away. Your provider will monitor you for up to 2 hours after each infusion to make sure you don't have any serious reactions.
Autoimmune problems
Based on how Enjaymo (sutimlimab) works, it's possible that the medication can raise your risk for other autoimmune problems, such as lupus. Your provider will monitor you for other autoimmune problems while you're taking Enjaymo (sutimlimab).
Return of CAD symptoms
After your provider determines you no longer need to take Enjaymo (sutimlimab), you'll still need to see your provider and be monitored to make sure your CAD symptoms don't come back. Contact your provider if you notice you're having CAD symptoms (e.g., feeling tired, shortness of breath, bloody or dark urine, racing heart, bluish or reddish color of skin). You might have to restart Enjaymo (sutimlimab).
Enjaymo (sutimlimab) dosage forms
Typical dosing for Enjaymo (sutimlimab)
Dosing depends on your body weight.
85 lbs to less than 165 lbs: The typical dose is 6,500 mg injected into the veins (intravenous or IV) once per week for 2 weeks, then every 2 weeks thereafter.
165 lbs or greater: The typical dose is 7,500 mg given IV once per week for 2 weeks, then every 2 weeks thereafter.
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