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Erythromycin/Benzoyl Peroxide Coupon - Erythromycin/Benzoyl Peroxide 46.6g of 3%/5% jar of gel

erythromycin / benzoyl peroxide

Generic Benzamycin
Used for Acne

Benzamycin (erythromycin / benzoyl peroxide) is a prescription topical gel used to treat acne in people 12 years and older. It's a combination of two medications: erythromycin (a macrolide antibiotic) and benzoyl peroxide (an antiseptic). It's applied to the affected skin twice a day, usually in the morning and evening. Side effects include skin dryness, itching, and burning.

Reviewed by:
reviewerRobert Chad Hakim, PharmD, BCCCP
reviewerDaisy Chau, PharmD
Last reviewed on August 7, 2026
basics-icon

What is Benzamycin (erythromycin / benzoyl peroxide)?

What is Benzamycin (erythromycin / benzoyl peroxide) used for?

  • Acne in people ages 12 years and older

How Benzamycin (erythromycin / benzoyl peroxide) works

Benzamycin (erythromycin / benzoyl peroxide) is a combination of two medications that work together to treat acne.

When does Benzamycin (erythromycin / benzoyl peroxide) start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
Initial effect
MONTHS
Full effect

Drug facts

Common BrandsBenzamycin
Drug ClassAntibiotic / antiseptic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Benzamycin (erythromycin / benzoyl peroxide)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry skin (3%)
  • Hives (3%)

Less Common Side Effects

  • Skin peeling
  • Itching
  • Burning
  • Redness
  • Swelling of face, eyes, and nose
  • Eye irritation

Benzamycin (erythromycin / benzoyl peroxide) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe diarrhea: watery diarrhea, bloody stools, severe stomach cramps, fever, dehydration

Source: DailyMed

The following Benzamycin (erythromycin / benzoyl peroxide) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare

Burning, blistering, crusting, itching, severe redness, or swelling of the skin

dryness or peeling of the skin

eye irritation

feeling of warmth, mild stinging, or redness of the skin

increased sensitivity of the skin to sunlight

oiliness or tenderness of the skin

painful irritation of the skin

redness or other discoloration of the skin

redness, swelling, or itching of the eyelid

severe sunburn

skin rash

swelling of the eyes, face, and nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See more Benzamycin (erythromycin / benzoyl peroxide) side effects
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Pros and cons of Benzamycin (erythromycin / benzoyl peroxide)

Pros

  • Combines two acne medications in one gel
  • Applied directly to the affected skin
  • Approved for adults and children ages 12 years and older

Cons

  • Must usually be applied twice daily
  • Can dry out or irritate your skin
  • Can bleach hair, towels, bedding, and clothing
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Pharmacist tips for Benzamycin (erythromycin / benzoyl peroxide)

pharmacist
  • Benzamycin (erythromycin / benzoyl peroxide) can cause redness, dryness, peeling, stinging, or burning where you apply it. Talk to your prescriber if these skin reactions become severe or don't go away.
  • Use a moisturizer as needed while using Benzamycin (erythromycin / benzoyl peroxide) to help prevent dry or irritated skin.
  • Avoid using other topical acne medications, including medicated soaps, cleansers, shampoos, at the same time as Benzamycin (erythromycin / benzoyl peroxide). Using them together can irritate your skin.
  • Benzamycin (erythromycin / benzoyl peroxide) can bleach your hair, clothing, towels, and bed sheets. Let the medication dry completely before getting dressed or lying down.
  • Storage: Keep Benzamycin (erythromycin / benzoyl peroxide) in the refrigerator once you get home. Throw it away after 3 months even if there is still medication left in the jar.

How to use Benzamycin (erythromycin / benzoyl peroxide):

  • Wash your hands before and after using the medication. Gently wash the affected skin with a mild cleanser and let it dry completely before applying the medication.
  • Apply a thin layer to the affected skin twice a day, usually in the morning and evening. Don't apply it to skin that is cut, scraped, or damaged.
  • Apply the gel to your skin only. Keep it out of your eyes, nose, and mouth because it can cause irritation.
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Risks and warnings for Benzamycin (erythromycin / benzoyl peroxide)

Benzamycin (erythromycin / benzoyl peroxide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Severe diarrhea

Although it's rare, Benzamycin (erythromycin / benzoyl peroxide) can cause a serious bowel infection called C. difficile-associated diarrhea (CDAD). This can happen because the antibiotic changes the normal bacteria in your gut.

Tell your care team right away if you have severe diarrhea, diarrhea that doesn't go away, stomach pain, fever, or bloody stools. Your prescriber might have you stop the medication and start treatment if needed.

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Benzamycin (erythromycin / benzoyl peroxide) dosage

The average cost for 1 jar of 46.6g of 3%/5% of Benzamycin (erythromycin / benzoyl peroxide) is $30.07 with a free GoodRx coupon. This is 90.50% off the average retail price of $316.58.
jar of gelJar of gel
DosageQuantityPrice as low asPrice per unit
23.3g of 3%/5%1 jar$35.96$35.96
46.6g of 3%/5%1 jar$30.07$30.07
See more Benzamycin (erythromycin / benzoyl peroxide) dosage
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Interactions between Benzamycin (erythromycin / benzoyl peroxide) and other drugs

Benzamycin (erythromycin / benzoyl peroxide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Benzamycin (erythromycin / benzoyl peroxide). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

See more Benzamycin (erythromycin / benzoyl peroxide) interactions
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How much does Benzamycin (erythromycin / benzoyl peroxide) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Benzamycin (brand)
GoodRx lowest price

$30.07

Benzamycin (erythromycin / benzoyl peroxide) (generic)
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$30.07

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What are alternatives to Benzamycin (erythromycin / benzoyl peroxide)?

There are a number of medications that your doctor can prescribe in place of Benzamycin (erythromycin / benzoyl peroxide). Compare a few possible alternatives below.
Benzamycin (erythromycin / benzoyl peroxide)
Used for:
  • Acne in people ages 12 years and older
$30.07Lowest GoodRx priceView prices
Used for:
$28.99Lowest GoodRx priceView prices
Used for:
  • Acne in
    • People 9 years and older - Epiduo
    • People 12 years and older - Epiduo Forte
$28.80Lowest GoodRx priceView prices
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Benzamycin (erythromycin / benzoyl peroxide) images

white - Erythromycin/Benzoyl Peroxide 3%-5% Topical Gel
This medicine is White Jar Of Gel.white - Erythromycin/Benzoyl Peroxide 3%-5% Topical Gel
white - Erythromycin/Benzoyl Peroxide 3%-5% Topical Gel
This medicine is White Jar Of Gel.white - Erythromycin/Benzoyl Peroxide 3%-5% Topical Gel

References

Best studies we found

Bausch Health Canada. (2020). BENZAMYCIN (erythromycin and benzoyl peroxide) topical gel, USP [product monograph].

Bausch Health US. (2020). BENZAMYCIN- erythromycin and benzoyl peroxide kit [package insert]. DailyMed.

Gupta, A. K., et al. (2003). A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face. Journal of Cutaneous Medicine and Surgery.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.