Macrolide-antiseptic combinations can treat acne and other skin conditions. These medications work by combining the antibacterial effects of macrolides with the antiseptic properties of other agents, helping to kill bacteria and reduce inflammation on your skin. These combinations are typically available in topical forms, such as gels, making them easy to apply directly to the affected area. One examples is erythromycin / benzoyl peroxide (Benzamycin).