Augtyro
Augtyro (repotrectinib) is a type of cancer medication called a kinase inhibitor. It’s used to treat adults with advanced non-small cell lung cancer (NSCLC) that has a ROS1 mutation. It’s also approved for people 12 years and older who have an advanced solid tumor with an NTRK mutation when other treatments haven’t worked well. Augtyro (repotrectinib) comes as a capsule that you take by mouth at home. Common side effects are dizziness, changes in taste, and numbness or tingling in the fingers or toes.
What is Augtyro (repotrectinib)?
What is Augtyro (repotrectinib) used for?
- Advanced or metastatic non-small cell lung cancer (NSCLC) with a ROS1 mutation in adults
- Advanced or metastatic solid tumors with an NTRK mutation in people 12 years and older who’ve tried other therapies
How Augtyro (repotrectinib) works
Augtyro (repotrectinib) is a type of targeted therapy called a kinase inhibitor. It works by finding specific mutated proteins on cancer cells that help the cancer grow.
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For non-small cell lung cancer: Augtyro (repotrectinib) attaches to the mutated ROS1 protein on lung cancer cells.
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For solid tumors: The medication attaches to the mutated NTRK protein on tumor cells.
After Augtyro (repotrectinib) attaches to these proteins, it blocks them from working. This can help slow down or stop the cancer from growing or spreading.
Drug facts
| Common Brands | Augtyro |
|---|---|
| Drug Class | Kinase inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Augtyro (repotrectinib)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Low hemoglobin levels (79%)
- Dizziness (65%)
- High creatinine phosphokinase (61%)
- Taste changes (54%)
- Numbness or tingling in the fingers or toes (49%)
- Low white blood cells (up to 43%)
- Higher liver enzyme levels (up to 41%)
- Constipation (38%)
- High sodium levels (33%)
- Trouble breathing (30%)
- Tiredness (30%)
- Trouble balancing, such as when walking (28%)
- Problems with brain function (e.g., memory problems, can’t pay attention, confusion; 25%)
Less Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Lower appetite
- Muscle weakness
- Muscle pain
- Headache
- Cough
- Weight gain
- Swelling
- Pneumonia
- Vision problems (e.g., blurry vision, dry eye, changes in vision, eye pain, light sensitivity)
- Slower blood clotting time
- Low phosphate levels
- High potassium levels
- Changes in blood sugar levels (high or low)
Augtyro (repotrectinib) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Lung problems: cough, trouble breathing, tight chest, chest pain
- Liver problems: yellow skin, yellow eyes, belly pain, belly swelling
- Fracture: strong bone pain, trouble moving an arm or leg, a bone that looks out of place
- Muscle damage: muscle pain, tenderness, or weakness
The following Augtyro (repotrectinib) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry cough, shortness of breath or trouble breathing
- High uric acid level—severe pain, redness, warmth, or swelling in joints, pain or trouble passing urine, pain in the lower back or sides
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
- Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Difficulty with paying attention, memory, or speech
- Dizziness
- Fatigue
- Nausea
- Pain, tingling, or numbness in the hands or feet
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Pros and cons of Augtyro (repotrectinib)
Pros
- A capsule that you take by mouth at home
- Works in a specific, targeted way against cancer cells
- Might help shrink tumors
Cons
- Often causes dizziness and changes in taste
- Need regular blood tests to check for safety
- Can interact with grapefruit and other medications
Pharmacist tips for Augtyro (repotrectinib)
- Take Augtyro (repotrectinib) at the same time each day. For the first 2 weeks, you can take it once a day. After that, you take it twice a day. Choose times during the day that are easy for you to remember, like after breakfast or dinner.
- If you miss a dose of Augtyro (repotrectinib) or vomit after taking it, skip that dose. Don’t take an extra dose to make it up. Just take the next dose at the next usual time.
- Swallow the Augtyro (repotrectinib) capsule whole to make sure it works as it should. Don’t open, chew, crush, or dissolve them. Don’t take any capsules that are broken, cracked, or damaged.
- You can take Augtyro (repotrectinib) with or without food. But be sure to avoid grapefruit and grapefruit juice. Grapefruit can raise the medication levels in your body and put you at risk of harmful side effects.
- Augtyro (repotrectinib) often causes dizziness, tiredness, and balance problems. It can also sometimes cause confusion. If you have these side effects, don’t drive or use machines. Tell your oncologist if the side effects affect your daily life. Depending on your side effects, your oncologist can see how they can help.
- Augtyro (repotrectinib) can cause taste changes. If you have taste changes that bother you or make you lose your appetite, let your oncology care team know. They might recommend you to meet with a dietician to help manage it.
- Watch out for any signs that you might have a broken bone. This could feel like a lot of pain in one spot, or you might find it hard to move your arm or leg. If you notice any of these things, go to an urgent care center right away to get it checked out. It’s not common, but some people taking Augtyro (repotrectinib) have had fractures.
- If you have muscle pain or soreness that you weren’t expecting, tell your oncology care team. Augtyro (repotrectinib) can sometimes irritate your muscles. Your oncologist might want to check for muscle problems.
- It’s important to get blood work done on schedule. Augtyro (repotrectinib) can affect your blood cell counts, electrolyte levels, and liver. It can also raise your creatinine phosphokinase (CPK) levels, which can be a sign of muscle damage. You might not notice symptoms, so blood tests help your oncology care team detect these side effects early. Ask your oncologist to go over your lab results with you.
- Tell your oncologist and pharmacist about all the medications you take and plan to take. Some medications can interact with Augtyro (repotrectinib). For example, some antifungals and antibiotics can raise your risk of side effects from the cancer medication. Other medications, like some seizure medications, can make Augtyro (repotrectinib) work less well. Your care team can check for drug interactions and make changes if needed to help keep you safe.
- Ask your oncology care team about the best way to handle and throw away Augtyro (repotrectinib) safely. Cancer medications can be harmful to people who handle or come in contact with them. Store the medication up and away, so children and pets can’t reach it.
- If you can become pregnant: Use a nonhormonal form of birth control while taking Augtyro (repotrectinib). Keep using it for 2 months after you stop taking the medication. Don’t rely only on hormonal birth control, like the pill, because it might not work as well with Augtyro (repotrectinib). It’s important to avoid pregnancy during treatment because Augtyro (repotrectinib) can harm an unborn baby. Tell your oncologist right away if you get pregnant.
- If your partner can become pregnant: Use birth control, such as condoms, while taking Augtyro (repotrectinib). Be sure to keep using condoms during sex for 4 months after you stop taking Augtyro (repotrectinib). This medication might harm an unborn baby. If you partner becomes pregnant while you’re taking Augtyro (repotrectinib), let your oncologist know right away.
Risks and warnings for Augtyro (repotrectinib)
Augtyro (repotrectinib) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Side effects affecting the nervous system
People taking Augtyro (repotrectinib) commonly have side effects like dizziness and balance problems. Other side effects include confusion, memory loss, mood changes, trouble sleeping, or too much sleepiness. Of these, dizziness is the most common. These side effects often start within days of treatment but can also happen months later.
Watch for any of these side effects while you’re taking Augtyro (repotrectinib). If they happen, talk to your oncology care team, especially if they make it hard for you to go about your day. Your oncologist can see if you need to take a lower dose of the medication or stop taking it altogether.
Lung problems
Serious lung problems aren’t common, they’ve happened in some people taking Augtyro (repotrectinib). These problems include interstitial lung disease (ILD) and pneumonitis. Both can cause lung inflammation and might lead to lung damage. In studies, these problems happened within weeks to months after starting treatment.
Symptoms of lung problems can include cough, trouble breathing, chest pain, and feeling very tired. If you have any of these symptoms while taking Augtyro (repotrectinib), get medical care right away. You might need to stop taking the medication while your care team checks your lungs.
Liver problems
Some people taking Augtyro (repotrectinib) had higher liver enzyme levels. This can be a sign of liver irritation or injury. These lab changes have most often happened about 2 weeks after starting treatment.
Your oncologist will check your liver enzyme levels during treatment. This is done every 2 weeks during the first month, then once a month and as needed. If your levels are abnormal, you might need to stop taking Augtyro (repotrectinib) until your liver health improves. Then, your prescriber might tell you to restart it at the same dose or a lower dose. If serious liver problems happen, you might need to stop taking it altogether.
Muscle pain
Augtyro (repotrectinib) can sometimes cause muscle pain. This can happen along with high creatine phosphokinase (CPK) levels, which can be a sign of muscle damage. Most times, muscle pain can start within days to a few weeks after starting treatment.
Your oncologist will check your CPK levels with blood tests during treatment. These tests are done every 2 weeks during the first month, and then as needed. Tell your care team if you have any muscle pain, tenderness, or weakness that you can’t explain. Depending on your symptoms, your prescriber might pause your treatment and then restart Augtyro (repotrectinib) at either the same dose or a lower dose.
High uric acid
Some people taking Augtyro (repotrectinib) have had high uric acid levels. High uric acid can raise the risk of gout, causing joint pain and swelling.
Your oncologist will check your uric acid levels with lab tests before and during treatment. If it’s too high, you might need to take a medication like allopurinol (Zyloprim) to bring it down. You might also need to pause Augtyro (repotrectinib) and then restart at a lower dose.
Fractures
- Risk factors: Cancer that has spread to the bones | Previous radiation to the bone
Fractures (broken bones) aren’t common, but they’ve happened in some people taking Augtyro (repotrectinib). These breaks can happen days to months after starting the medication. Reported fractures have been in the ribs, chest, back, hip, ankles, and feet. Some were in areas where the cancer was or where radiation was given.
Watch for signs of a broken bone. This can include strong bone pain, trouble moving an arm or leg, or a bone that looks out of place. If you notice any of these signs, go to urgent care to check it out.
Harm to an unborn baby
- Risk factors: Pregnancy
Based on animal studies and the way Augtyro (repotrectinib) works, it can cause harm to an unborn baby. If you can get pregnant, use nonhormonal birth control while taking Augtyro (repotrectinib). Continue for 2 months after your last dose. Avoid using hormonal birth control, like birth control pills, because it might not work as well with the medication.
If you can father a child and have a partner who can become pregnant, use birth control like condoms while taking Augtyro (repotrectinib) and for 4 months after stopping.
If you or your partner becomes pregnant during treatment, tell your oncology care team right away.
Augtyro (repotrectinib) dosage
Capsule| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 40mg | 240 capsules | $30,697.07 | $127.90 |
Typical dosage for Augtyro (repotrectinib)
The typical dose is 160 mg by mouth once a day for 14 days. After that, the usual dose is 160 mg by mouth twice a day.
Your oncologist can lower your dose if you have bothersome or serious side effects from the medication.
How much does Augtyro (repotrectinib) cost?
$30,697.07
