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Trimipramine

Trimipramine Side Effects

Allison Gourley, PharmDMichelle Nguyen, PharmD
Reviewed by Allison Gourley, PharmD, Michelle Nguyen, PharmD
Last reviewed on January 14, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Blood pressure changes
  • Feeling of pins and needles in your arms and legs
  • Dry mouth
  • Blurred vision
  • Nausea and vomiting

Less Common Side Effects

  • Skin rash
  • Loss of appetite
  • Change in sex drive
  • Headache
  • Stomach cramps

Trimipramine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts and behaviors
  • Serotonin syndrome: high fever, sudden changes in thought, mood, and movement, or high blood pressure
  • Heart attack: new or worsening chest pain, fast or irregular heartbeat, dizziness, tiredness, clammy skin, nausea, vomiting
  • Stroke: tiredness, weakness, difficulty speaking, difficulty maintaining balance, headache, feeling confused, not able to move one side of your body

Source: DailyMed

The following Trimipramine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

agitation

black, tarry stools

bleeding or bruising

blood in the urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

clay-colored stools

cold sweats

confusion about identity, place, and time

continuing ringing, buzzing, or other unexplained noise in the ears

convulsions

cool, pale skin

cough or hoarseness

dark urine

decrease in the frequency of urination

decreased urine output or volume

depression

difficulty in passing urine (dribbling)

difficulty with speaking

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

drooling

dry mouth

false beliefs that cannot be changed by facts

fast, pounding, or irregular heartbeat or pulse

feeling of warmth

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

feeling, seeing, or hearing things that are not there

fever with or without chills

flushed, dry skin

fruit-like breath odor

general feeling of tiredness or weakness

headache

hearing loss

hostility

hyperventilation

inability to move the arms, legs, or facial muscles

inability to speak

increased hunger

increased need to urinate

increased thirst

increased urination

irritability

itching or rash

lack of coordination

lethargy

loss of appetite

loss of balance control

lower back or side pain

mood or mental changes

muscle spasm or jerking of all extremities

muscle trembling or stiffness

muscle twitching

nausea

nightmares

pain or discomfort in the arms, jaw, back, or neck

painful or difficult urination

passing urine more often

pinpoint red or purple spots on the skin

pounding in the ears

rapid weight gain

redness of the face, neck, arms, and occasionally, upper chest

restlessness

shakiness and unsteady walk

shuffling walk

slow speech

slurred speech

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stiffness of the limbs

sudden loss of consciousness

sweating

swelling of the face, ankles, legs, or hands

swollen glands

talking, feeling, and acting with excitement

trouble in holding or releasing urine

trouble sleeping

twisting movements of the body

uncontrolled movements, especially of the face, neck, and back

unpleasant breath odor

unsteadiness, awkwardness, trembling, or other problems with muscle control or coordination

unusual behavior

unusual tiredness or weakness

vomiting of blood

weakness in the arms, hands, legs, or feet

weight gain or loss

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Abdominal or stomach cramps

bigger, dilated, or enlarged pupils (black part of the eye)

black tongue

bloating

decreased interest in sexual intercourse

diarrhea

difficulty having a bowel movement (stool)

disturbance of accommodation

enlargement of the breast

hair loss or thinning of the hair

heartburn

hives or welts

inability to have or keep an erection

increase in sexual ability, desire, drive, or performance

increased sensitivity of the eyes to light

increased sensitivity of the skin to sunlight

loss in sexual ability, desire, drive, or performance

pain or discomfort in the chest, upper stomach, or throat

peculiar taste

redness or other discoloration of the skin

severe sunburn

small red or purple spots on the skin

swelling of the breasts or breast soreness in both women and men

swelling of the testicles

swelling or inflammation of the mouth

swollen, painful, or tender lymph glands in the neck

unexpected milk flow from the breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Michelle Nguyen, PharmD, has been a clinical pharmacist for 6 years (and counting). She has a diverse skill set within managed care pharmacy, specifically in the settings of a medical group, pharmacy benefit manager (PBM), and health plan.

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