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Amoxapine

Amoxapine Side Effects

Hope Chang, PharmD, AAHIVPKristianne Hannemann, PharmD
Reviewed by Hope Chang, PharmD, AAHIVP, Kristianne Hannemann, PharmD
Last reviewed on June 7, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness (14%)
  • Dry mouth (14%)
  • Constipation (12%)
  • Blurred vision (7%)

Less Common Side Effects

  • Restlessness
  • Nervousness
  • Headache
  • Dizziness
  • Tiredness
  • Weakness
  • Trouble sleeping (insomnia)
  • Tremors
  • Nausea
  • Large appetite
  • Irregular heartbeat
  • More sweating than usual
  • Rash

Amoxapine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behavior
  • Neuroleptic malignant syndrome (NMS): high fever, fast heart rate, full body stiffness, confusion
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Source: DailyMed

The following Amoxapine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Excitement

fast, irregular, pounding, or racing heartbeat or pulse

fear or nervousness

mood or mental changes

nightmares

restlessness

shakiness and unsteady walk

shakiness in legs, arms, hands, or feet

sleeplessness

swelling

trouble sleeping

unable to sleep

unsteadiness, trembling, or other problems with muscle control or coordination

Rare

Abdominal or stomach pain

actions that are out of control

black, tarry stools

bleeding gums

bloating

blood in urine or stools

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

chills

clay-colored stools

confusion

confusion about identity, place, and time

constipation

continuing ringing or buzzing or other unexplained noise in ears

convulsions

cough or hoarseness

dark urine

decrease in frequency of urination

decrease in urine volume

difficulty in breathing

difficulty in passing urine (dribbling)

difficulty in speaking

disturbed concentration

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

double vision

drooling

extremely high fever or body temperature

false beliefs that cannot be changed by facts

fast, weak heartbeat

fever with or without chills

general feeling of tiredness or weakness

headache

hearing loss

high fever

high or low blood pressure

hives or welts

inability to move arms, legs, or facial muscles

inability to speak

increased need to urinate

increased sweating

indigestion

irritability

itching

lack of coordination

light-colored stools

lip smacking or puckering

loss of appetite

loss of bladder control

lower back or side pain

muscle cramps

muscle spasm or jerking of all extremities

muscle trembling, jerking, or stiffness

nausea and vomiting

nervousness

numbness

pain or discomfort in arms, jaw, back, or neck

painful or difficult urination

pains in stomach, side, or abdomen, possibly radiating to the back

pale, clammy skin

passing urine more often

pinpoint red spots on skin

pounding in the ears

puffing of cheeks

rapid or worm-like movements of tongue

redness of skin

seeing, hearing, or feeling things that are not there

severe muscle stiffness

shortness of breath

shuffling walk

skin rash

slow speech

sore throat

sores, ulcers, or white spots on lips or in mouth

stiffness of limbs

sudden loss of consciousness

sweating

swollen glands

talking, feeling, and acting with excitement

testicular swelling

thirst

trouble in holding or releasing urine

twisting movements of body

uncontrolled chewing movements

uncontrolled movements, especially of face, neck, and back

unpleasant breath odor

unusual bleeding or bruising

unusually pale skin

upper right abdominal pain

vomiting of blood

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Change in consciousness

drowsiness

epileptic seizure that will not stop

fatigue

increased blood pressure

increased thirst

loss of consciousness

swelling of face, fingers, or lower legs

total body jerking

troubled breathing

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dry mouth

Less common

Increased appetite

increased flow of breast milk

Rare

Agitation

breast enlargement

change in taste bad unusual or unpleasant (after)taste

decreased interest in sexual intercourse

depression

excess air or gas in stomach or intestines

full feeling

hair loss, thinning of hair

heartburn

inability to have or keep an erection

increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

increased sensitivity of skin to sunlight

loss in sexual ability, desire, drive, or performance

menstrual changes

nasal stuffiness

painful ejaculation

passing gas

rapid weight gain

redness or other discoloration of skin

seizures

severe sunburn

stupor

swollen, painful, or tender lymph glands on side of face or neck

tearing of the eyes

unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Hope Chang is a freelance writer and content reviewer for GoodRx. She attended Howard University College of Pharmacy in Washington, D.C. and completed post-graduate residency training at the University of California, Davis Medical Center.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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