Skip to main content
Anafranil

Anafranil Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on October 17, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth (63-84%)
  • Sleepiness (46-54%)
  • Dizziness (41-54%)
  • Tremor (33-54%)
  • Headache (28-52%)
  • Constipation (22-47%)
  • Sexual problems in males (6-42%)
  • Tiredness (35-39%)
  • Nausea (9-33%)
  • Sweating more (9-29%)
  • Trouble sleeping (11-25%)

Less Common Side Effects

  • Changes in sex drive
  • Indigestion
  • Weight gain
  • Nervousness
  • Trouble urinating
  • Vision changes
  • Stomach pain
  • Changes in appetite
  • Trouble remembering
  • Anxiety
  • Rash

Anafranil serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Seizures
  • Low sodium level: headache, difficulty concentrating or remembering, weakness, feeling unsteady on your feet, seizure, coma
  • Serotonin syndrome: fast heartbeat, sweating, muscle stiffness or spasms, fever, confusion
  • Serious skin reaction: rash, itching, fever
When do Anafranil possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Dry mouth
Constipation
Sleepiness
Tremor
Risk of mood changes
Seek immediate medical care if you experience this side effect.

Source: DailyMed

The following Anafranil side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bladder pain

bloody or cloudy urine

blurred vision

body aches or pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

confusion

difficult, burning, or painful urination

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

excessive muscle tone

fear or nervousness

feeling sad or empty

fever

hearing changes

hives or welts, skin rash

irritability

lower back or side pain

muscle stiffness, tension, or tightness

poor concentration

rhythmic movement of muscles

sneezing

tightness of the chest

trouble breathing

unusual tiredness or weakness

voice changes

Less common

Anger that is hard to control

anxiety

breast enlargement

changes in vision

chest pain or discomfort

chills

decrease in the frequency of urination

deep or fast breathing with dizziness

difficulty in speaking

dry mouth

fast, irregular, pounding, or racing heartbeat or pulse

headache, severe and throbbing

nausea

numbness of the feet, hands, and around the mouth

numbness, tingling, pain, or weakness in the hands or feet

pain during sexual intercourse

paranoia

rapidly changing moods

restlessness

shaking

sores, ulcers, or white spots on the lips or tongue or inside the mouth

sweating

swelling of the face, fingers, feet, or lower legs

vomiting

Incidence not known

Agitation

blindness

cough

decreased awareness or responsiveness

depression

dizziness

eye pain

hostility

increased thirst

loss of consciousness

muscle pain, cramps, or twitching

rapid weight gain

seizures

severe sleepiness

sore throat

swollen, painful, or tender lymph glands in the neck, armpit, or groin

tearing

unusual drowsiness, dullness, or feeling of sluggishness

yellow skin or eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blistering, crusting, irritation, itching, or reddening of the skin

change in taste

constipation

cracked, dry, or scaly skin

change in interest in sexual intercourse

diarrhea

dry skin

heartburn

inability to have or keep an erection

increased interest in sexual intercourse

joint pain or swelling

pimples

redness of the face, neck, arms, and occasionally, upper chest

shakiness in the legs, arms, hands, or feet

stomach discomfort, upset, or pain

swelling

trembling or shaking of the hands or feet

Less common

Absent, missed, or irregular menstrual periods

breast pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

why trust our exports reliability shield

Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

Was this page helpful?

Latest articles