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Triamterene/HCTZ

Triamterene/HCTZ Side Effects

Allison Gourley, PharmDConnie Zheng, PharmD
Reviewed by Allison Gourley, PharmD, Connie Zheng, PharmD
Last reviewed on May 16, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache
  • Tiredness
  • Dizziness
  • Muscle cramps

Less Common Side Effects

  • Dry mouth
  • Blurred vision
  • Nausea
  • Vomiting
  • Diarrhea
  • Orthostatic hypotension - low blood pressure when you move from lying/sitting down to standing up

Triamterene/HCTZ serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious skin reaction: fever, sore throat, skin pain, rash that spreads, blisters, peeling skin
  • Dangerously high potassium levels: feeling that heart is racing, trouble breathing, chest pain, nausea, vomiting, weakness, tingling sensation
  • High levels of acid in the blood (acidosis): confusion, fast heartbeat, feeling sick to your stomach, headache, tiredness
  • Severe allergic reactions: severe rash, trouble breathing, closing of the throat
When do Triamterene/HCTZ possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Headache
Tiredness
Dizziness
Risk of muscle cramps
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Triamterene/HCTZ side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
  • Goutsevere pain, redness, warmth, or swelling in joints such as the big toe
  • High potassium level—muscle weakness, fast or irregular heartbeat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Kidney stones—blood in the urine, pain or trouble passing urine, pain in the lower back or sides
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Sudden eye pain or change in vision, such as blurry vision, seeing halos around lights, vision loss

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

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