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Amiloride/HCTZ

Amiloride/HCTZ Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on September 5, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Side effects occurring in up to 8% of people:

  • Headache
  • Weakness
  • Dizziness
  • Nausea
  • Lower appetite
  • Rash

Less Common Side Effects

  • Feeling tired
  • Irregular heartbeat
  • Diarrhea
  • Stomach pain
  • Shortness of breath
  • Itchiness
  • Gout
  • Dehydration

Amiloride/HCTZ serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: swelling of your lips, tongue, throat, or face; trouble breathing; rash
  • High potassium levels: nausea, muscle weakness, abnormal heartbeat
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Source: DailyMed

The following Amiloride/HCTZ side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Confusion

difficulty breathing

irregular heartbeat

nausea or vomiting

nervousness

numbness or tingling in the hands, feet, or lips

stomach pain

trouble breathing

weakness or heaviness of the legs

Less common

Dizziness

fainting

fast or slow heartbeat

labored breathing

tightness in the chest

Rare

Ankle, knee, or great toe joint pain

arm, back, or jaw pain

blistering, peeling, or loosening of the skin

bloody or black, tarry stools

bloody urine

burning while urinating

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain, discomfort, or heaviness

chills

cloudy urine

cold sweats

coma

constipation

cough

cracks in the skin

decreased awareness or responsiveness

decreased frequency or amount of urine

diarrhea

difficult or painful urination

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

dry mouth

fever

headache

increase in heart rate

increased blood pressure

increased thirst

itching

joint pain, stiffness, or swelling

lightheadedness

loss of appetite

loss of heat from the body

lower back or side pain

muscle pain or cramps

pounding heartbeat or pulse

rapid breathing

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

scaly skin

seizures

severe sleepiness

severe stomach pain

sore throat

sores, ulcers, or white spots in the mouth or on the lips

sunken eyes

sweating

swelling of the face, ankles, hands, fingers, or lower legs

trouble breathing

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

weight gain

wrinkled skin

Incidence not known

Persistent non-healing sore

pink growth

reddish patch or irritated area

shiny bump

white, yellow or scar-like area

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Drowsiness

irritability

mood changes

pain or weakness in the hands or feet

trembling

weak pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Rash

weight loss

Less common

Leg ache

Rare

Bad taste

bloated, full feeling

blurred or loss of vision

changes in appetite

decreased interest in sexual intercourse

discouragement

disturbed color perception

double vision

excess air or gas in the stomach or intestines

feeling of constant movement of self or surroundings

feeling of warmth

feeling sad or empty

general feeling of discomfort or illness

hair loss or thinning of hair

hiccups

inability to have or keep an erection

increased sweating

increased urge to urinate during the night

indigestion

loss in sexual ability, desire, drive, or performance

loss of bladder control

loss of interest or pleasure

muscle spasm

night blindness

overbright appearance of lights

passing of gas

redness of the face, neck, arms, and occasionally upper chest

seeing halos around lights

sensation of spinning

sleepiness

sleeplessness

stomach fullness or discomfort

stuffy nose

swelling of the breasts or breast soreness in both females and males

trouble concentrating

trouble sleeping

tunnel vision

unable to sleep

waking to urinate at night

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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