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Stiolto Respimat Coupon - Stiolto Respimat 60 inhalations of 2.5mcg/2.5mcg respimat inhaler

Stiolto Respimat

tiotropium / olodaterol
Used for COPD

Stiolto Respimat is a combination inhaler. It's used to treat chronic obstructive pulmonary disease (COPD) in adults. The inhaler contains two medications: tiotropium (a long-acting muscarinic antagonist) and olodaterol (a long-acting beta agonist). It helps keep the airways open and make breathing easier. Stiolto Respimat (tiotropium / olodaterol) is used once every day. Each time, you use 2 inhalation sprays and inhale them by mouth. Side effects can include upper respiratory tract infections and cough.

Reviewed by:Last reviewed on July 15, 2026
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What is Stiolto Respimat (tiotropium / olodaterol)?

What is Stiolto Respimat (tiotropium / olodaterol) used for?

How Stiolto Respimat (tiotropium / olodaterol) works

Stiolto Respimat (tiotropium / olodaterol) is a combination of two medications that work together to help open up your airways.

When does Stiolto Respimat (tiotropium / olodaterol) start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
DAYS
WEEKS
Full effect
MONTHS

Drug facts

Common BrandsStiolto Respimat
Drug ClassLAMA / LABA
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
side-effects-icon

Side effects of Stiolto Respimat (tiotropium / olodaterol)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

  • Dizziness
  • Trouble sleeping
  • Blurry vision
  • Dry mouth
  • Sore throat
  • Hoarseness
  • Trouble urinating
  • Abnormal heartbeat
  • Rash

Stiolto Respimat (tiotropium / olodaterol) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Sudden tightening of your airways: trouble breathing, wheezing, cough, chest pain or tightness
  • Heart problems: dizziness, tiredness, weakness, tremor, irregular heartbeat, worsening symptoms of heart problem that you already have
  • Allergic reaction: hives; itchiness; swelling of your face, lips, or tongue; trouble breathing

Source: DailyMed

The following Stiolto Respimat (tiotropium / olodaterol) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Muscle pain or cramps
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Trouble passing urine
  • Wheezing or trouble breathing that is worse after use

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

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Pros and cons of Stiolto Respimat (tiotropium / olodaterol)

Pros

Cons

  • Can take several weeks to get the full effect of the medication
  • Doesn't replace your rescue inhaler for sudden trouble breathing
  • Might worsen certain medical conditions, such as trouble urinating or glaucoma
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Pharmacist tips for Stiolto Respimat (tiotropium / olodaterol)

pharmacist
  • You can use Stiolto Respimat (tiotropium / olodaterol) at any time of the day, but try to use it at the same time every day. Remember to take 2 inhalations each time, one after the other. This helps the medication work the best it can to prevent COPD attacks.
  • If you have sudden trouble breathing, use your rescue inhaler right away. Stiolto Respimat (tiotropium / olodaterol) won't help with a COPD attack as it's happening. This is because it can't work fast enough to open up your airways in this situation.
  • Call your prescriber if your COPD gets worse while using Stiolto Respimat (tiotropium / olodaterol). Also tell them if you need to use your rescue inhaler more often than usual or if it isn't working well as well as it used to. These can be signs that your treatment might need to be adjusted to better control your COPD.
  • Tell your prescriber and pharmacist about all the medications you take. Some medications can interact with Stiolto Respimat (tiotropium / olodaterol). For example, taking other anticholinergic medications, like tolterodine (Detrol) or hyoscyamine, can raise your risk of side effects like dry mouth, constipation, and trouble urinating. Also, beta blockers might make your inhaler work less well. Your care team can help make sure your medications are safe to take together.
  • Store Stiolto Respimat (tiotropium / olodaterol) at room temperature (68ºF to 77ºF).

How to use Stiolto Respimat (tiotropium / olodaterol):

  • Your care team will help show you how to use Stiolto Respimat (tiotropium / olodaterol). Read the directions or watch the instructional video on how to put the inhaler together and use it. Don't spray the medication into the eyes. Ask your care team if you have any questions.
  • Always use a new cartridge with a new Stiolto Respimat (tiotropium / olodaterol) inhaler. Don't reuse cartridges or inhalers.
  • How to assemble your Stiolto Respimat (tiotropium / olodaterol) inhaler: Press the safety catch button and pull off the clear base without touching the piercing element on the bottom. Insert the cartridge into the inhaler and push it down on a flat surface until it clicks into place. Reattach the clear base onto the inhaler.
  • How to prime your Stiolto Respimat (tiotropium / olodaterol) inhaler: With the cap closed, follow the arrows to turn the clear base until it clicks. Then, open the cap fully. Point the inhaler toward the ground and press the dose-release button. Repeat until you see 4 mists, then the inhaler is ready to use.
  • When to prime your Stiolto Respimat (tiotropium / olodaterol) inhaler: Always prime a new inhaler before using it. Also prime the inhaler if you haven't used your inhaler for more than 3 weeks. If you haven't used it more than 3 days, prime it by releasing 1 visible stream of mist towards the ground before you use it.
  • How to use your Stiolto Respimat (tiotropium / olodaterol) inhaler: Remember TOP (turn, open, and press). Turn the base in the direction of the arrows on the inhaler until you hear a click (half a turn). Open the cap. Then, breathe out slowly and completely before placing the mouthpiece in your mouth. Be careful not to cover the air vents. Point the inhaler towards the back of your throat. Then, press the dose-release button while you take a slow, deep breath through your mouth. Hold your breath for 10 seconds, or as long as you comfortably can.
  • How to clean your Stiolto Respimat (tiotropium / olodaterol) inhaler: Clean the mouthpiece (including the metal part inside) with a damp cloth or tissue at least once a week. It's okay if the mouthpiece gets a little discolored.
  • When to throw away the Stiolto Respimat (tiotropium / olodaterol) inhaler: Throw it away 3 months after you insert the cartridge, even if there's medication left inside. It can be helpful to write the "discard by" date on the label when you first insert the cartridge so you remember. Also throw the inhaler away if it becomes empty and locks or if it reaches its expiration date. Throw the inhaler away when the first of any of these happens.
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Risks and warnings for Stiolto Respimat (tiotropium / olodaterol)

Stiolto Respimat (tiotropium / olodaterol) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Not for COPD flare-ups or worsened breathing

Don't use Stiolto Respimat (tiotropium / olodaterol) for COPD flare-ups or sudden breathing problems. This medication doesn't work fast enough to help in these situations. Use your rescue inhaler, such as albuterol, if you suddenly have trouble breathing.

Tell your prescriber if you need to use your rescue inhaler more often than usual. Also let them know if your rescue inhaler doesn't seem to work well anymore. These can be signs that your COPD is getting worse.

Also, don't use more Stiolto Respimat (tiotropium / olodaterol) than recommended. It won't improve your breathing. Instead, it can raise your risk of serious side effects, such as heart problems, tremors, and dizziness.

Narrowing of your airways (bronchospasm)

In rare cases, inhaled medications like Stiolto Respimat (tiotropium / olodaterol) can cause the airways to suddenly tighten. This can lead to trouble breathing, wheezing, cough, or chest discomfort. If you have trouble breathing after using Stiolto Respimat (tiotropium / olodaterol), use your rescue inhaler and get medical help right away.

Allergic reaction

  • Risk factors: Allergy to ipratropium, tiotropium, or olodaterol

It's possible to have an allergic reaction to Stiolto Respimat (tiotropium / olodaterol). This can include a life-threatening reaction called anaphylaxis. Get medical help right away if you notice hives or itchiness. Also call 911 right away if you notice swelling of the face, lips, or tongue or trouble breathing.

Heart problems

  • Risk factors: High blood pressure | Heart failure | Heart rate or heart rhythm problems | Using more Stiolto Respimat (tiotropium / olodaterol) than recommended | Using with other LABAs

Stiolto Respimat contains olodaterol, which can sometimes raise your blood pressure and heart rate. It can also sometimes cause changes in your heart rhythm. This isn't common when you use the medication as directed. But the risk can be higher if you use it more often than recommended or use other LABAs at the same time.

If you have high blood pressure or other heart problems, your prescriber might ask you to check your blood pressure and heart rate at home. Don't use Stiolto Respimat (tiotropium / olodaterol) more often than prescribed. If you feel like you need to use it more often, tell your care team. They can see if your treatment plan needs to be adjusted to help you breathe better.

Tell your care team if you notice dizziness, tiredness, tremor, a fast heartbeat, or weakness while using Stiolto Respimat (tiotropium / olodaterol). These could be signs of heart-related side effects.

Eye problems (glaucoma)

  • Risk factors: History of glaucoma | Accidentally getting Stiolto Respimat (tiotropium / olodaterol) into the eye | Using the nebulizer machine incorrectly

In rare cases, Stiolto Respimat (tiotropium / olodaterol) can raise the pressure in the eyes. This can sometimes cause or worsen glaucoma. If you already have glaucoma or other eye problems, tell your optometrist or ophthalmologist that you're taking Stiolto Respimat (tiotropium / olodaterol). They can monitor your eyes more closely.

Call your prescriber or eye specialist right away if you notice any changes to your vision while using Stiolto Respimat (tiotropium / olodaterol). This can include eye pain, blurry vision, halos around lights, or eye redness. These can be signs of a serious eye problem.

Trouble urinating

  • Risk factors: Enlarged prostate | Bladder-neck obstruction (blockage)

Tell your prescriber if you have prostate problems or trouble emptying your bladder. Stiolto Respimat contains tiotropium, which can make these problems worse.

Let your prescriber know right away if you have more trouble urinating or pain when you urinate while using Stiolto Respimat (tiotropium / olodaterol). They can help figure out what might be going on and see how they can help.

Low potassium levels

Stiolto Respimat contains olodaterol, which can sometimes cause low potassium levels. This isn't common. But if it does happen, the drop is usually temporary. To be safe, it's a good idea to be aware of the symptoms of low potassium. This can include tiredness, weakness, muscle cramps, and a racing heart. If you notice these symptoms, talk to your care team.

Higher blood sugar

  • Risk factors: Using too much Stiolto Respimat (tiotropium / olodaterol)

Stiolto Respimat contains olodaterol, which can cause your blood sugar to rise. This isn't common, though it's more likely to happen if you inhale high doses of the medication. Don't use more Stiolto Respimat (tiotropium / olodaterol) than prescribed. Talk to your prescriber if your COPD medication doesn't seem to be helping your breathing.

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Stiolto Respimat (tiotropium / olodaterol) dosage

The average cost for 1 respimat inhaler of 60 inhalations of 2.5mcg/2.5mcg of Stiolto Respimat (tiotropium / olodaterol) is $479.28 with a free GoodRx coupon. This is 27.23% off the average retail price of $658.65.
respimat inhalerRespimat inhaler
DosageQuantityPrice as low asPrice per unit
60 inhalations of 2.5mcg/2.5mcg1 respimat inhaler$479.28$479.28
28 metered inhalations of 2.5mcg/2.5mcg1 respimat inhaler$206.08$206.08
10 metered inhalations of 2.5mcg/2.5mcg1 respimat inhaler$78.25$78.25
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How much does Stiolto Respimat (tiotropium / olodaterol) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
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Stiolto Respimat (tiotropium / olodaterol) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Stiolto Respimat (tiotropium / olodaterol) will not be safe for you to take.

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What are alternatives to Stiolto Respimat (tiotropium / olodaterol)?

There are a number of medications that your doctor can prescribe in place of Stiolto Respimat (tiotropium / olodaterol). Compare a few possible alternatives below.
Stiolto Respimat (tiotropium / olodaterol)
Used for:
$78.25Lowest GoodRx priceView prices
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$275.62Lowest GoodRx priceView prices
Used for:
  • Maintenance treatment of COPD
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News about Stiolto Respimat (tiotropium / olodaterol)

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Stiolto Respimat (tiotropium / olodaterol) images

This medicine is Colorless Respimat Inhaler.

References

Best studies we found

Alagha, K., et al. (2014). Long-acting muscarinic receptor antagonists for the treatment of chronic airway diseases. Therapeutic Advances in Chronic Disease.

American Academy of Allergy, Asthma & Immunology. (2026). Long-acting beta-agonists (LABAs).

Anderson, P. (2006). Use of Respimat® soft mist™ inhaler in COPD patients. International Journal of Chronic Obstructive Pulmonary Disease.

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