Supartz Fx (sodium hyaluronate) is a viscosupplement that's injected into the knee joint to ease pain from osteoarthritis (OA) in adults. It's typically prescribed for people who continue to have knee pain despite having tried certain treatments, such as exercises and acetaminophen (Tylenol). It helps lubricate and cushion the knee joint. Supartz Fx (sodium hyaluronate) is injected by a healthcare professional once a week for 3 or 5 weeks. Joint pain, back pain, and injection site reactions are some possible side effects.
Pain due to osteoarthritis (OA) of the knee
Supartz Fx (sodium hyaluronate) is a viscosupplement. It's similar to hyaluronic acid, a substance that's naturally found in the connective tissues in your body. When Supartz Fx (sodium hyaluronate) is injected into the knee, it helps lubricate the knee joint so that you can move it smoothly. This can ease pain from osteoarthritis in the knee.
Source: Prescribing Information
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Can improve pain for up to 6 months
Pain relief might last longer than corticosteroids
Good option for people who've tried other treatments that didn't work well
Less side effects than some oral treatment options
Might need 5 injections
Must be given by a healthcare professional
Not the best choice for people with an egg allergy
Not studied in children
Mark your appointments to get your Supartz Fx (sodium hyaluronate) injections on your calendar so you don't miss any doses.
Your prescriber might have you avoid physical activity after receiving Supartz Fx (sodium hyaluronate). In general, take things easy for the first 48 hours right after your injection. You should avoid strenuous activities such as running, jumping, swimming, biking or standing on your feet for more than 1 hour at a time. Ask your prescriber when you can continue these physical activities again.
You can expect to experience temporary pain and swelling in the knee where Supartz Fx (sodium hyaluronate) was injected. This is typically mild and should go away after 1 to 3 days. But if it doesn't, contact your prescriber.
If you're pregnant or breastfeeding, talk to your prescriber about the risks and benefits of receiving Supartz Fx (sodium hyaluronate). There isn't enough information to know if it's safe for you or your baby.
Supartz Fx (sodium hyaluronate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Allergy to sodium hyaluronate, avian (bird) proteins, feathers, or egg products
Supartz Fx (sodium hyaluronate) can cause life-threatening allergic reactions (e.g., anaphylaxis). If you have a history of an allergic reaction to hyaluronate products, bird products, feathers, or egg products, you're at a higher risk of having a reaction to Supartz Fx (sodium hyaluronate). Make sure to tell your prescriber all of your allergies. If you experience rash, trouble breathing, or swelling in your lips, tongue, or throat, get medical help right away.
Each Supartz FX injection contains 25 mg of sodium hyaluronate.
Adults: The typical dose is one injection given into the knee joint by a healthcare professional (HCP) once a week for 3 or 5 weeks.
Current infection or skin problems in area of injection
Known allergy to hyaluronate products
Pain due to osteoarthritis (OA) of the knee
Allergies or allergic reactions
Conditions affecting certain hormones (e.g., low adrenal hormones)
Gut conditions (e.g., ulcerative colitis)
Conditions related to blood cells
Certain cancers (e.g., leukemia)
Nervous system conditions (e.g., multiple sclerosis)
Eye conditions
Kidney conditions
Lung conditions
Joint conditions (e.g., rheumatoid arthritis)
Pain due to osteoarthritis (OA) of the knee
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Altman, R. D. (2000). Intra-articular sodium hyaluronate in osteoarthritis of the knee. Seminars in Arthritis and Rheumatism.
Bioventus LLC. (2015). Supartz FX (sodium hyaluronate).
Bronstone, A., et al. (2019). Supartz (sodium hyaluronate) for the treatment of knee osteoarthritis: A review of efficacy and safety. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders.
Foran, J. R. H. (2021). Viscosupplementation treatment for knee arthritis. OrthoInfo.
McArthur, B. A., et al. (2012). Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee. Patient Preference and Adherence.
Peck, J., et al. (2021). A comprehensive review of viscosupplementation in osteoarthritis of the knee. Orthopedic Reviews.
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