Solosec (secnidazole) is an oral nitroimidazole antibiotic. It's used to treat bacterial vaginosis (a type of vaginal bacteria infection) and trichomoniasis (a sexually transmitted infection) in people age 12 years and older. Treatment of Solosec (secnidazole) is only one dose taken by mouth. The medication comes in a packet of granules that you can sprinkle onto soft food. You shouldn't take Solosec (secnidazole) with alcohol because it can worsen side effects, such as nausea and vomiting.
Solosec (secnidazole) is a nitroimidazole antibiotic. It kills bacteria and parasites by damaging their DNA.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
A study showed that about 58% of people who took Solosec (secnidazole) for BV were considered cured of the infection 1 to 2 weeks after their dose. This means the person has normal vaginal discharge with no fishy odor, as well as laboratory results that show minimal BV-causing bacteria. Keep in mind that everyone responds differently to the medication. Another study showed that some people were considered cured of BV 3 to 4 weeks after their dose of Solosec (secnidazole). If you're taking this medication for BV and your symptoms don't start to improve after a week, talk to your healthcare team.
In clinical studies, most people who took a dose of this medication for BV experienced major improvements in their symptoms or were considered completely cured after 7 to 14 days. Similarly, people who took this medication for trich were also cured after 6 to 12 days. Make sure to take Solosec (secnidazole) exactly as prescribed. It's important to finish your treatment dose since not completing your antibiotic can make your infection come back and become harder to treat.
Solosec (secnidazole) can stay in your system for about 4 days after a single dose. This is estimated base on the half-life of the medication. But half-life can also vary from person to person. It's often affected by many factors, such as age and medical history. Because Solosec (secnidazole) can stay in your body for up to 4 days, it can cause side effects or lead to interactions during this time. For example, Solosec (secnidazole) can pass into breastmilk, so nursing mothers should stop breastfeeding for 4 days after the dose; they're recommended to feed their babies previously stored milk or formula instead.
Solosec (secnidazole) is available in a 2-gram packet of granules. To take this medication, sprinkle the granules onto applesauce, yogurt or pudding and take by mouth within 30 minutes. You can drink some water afterwards to help you swallow all the medication. Make sure you don't chew or crunch the oral granules. Doing so can affect how the medication gets absorbed into your body.
There's not enough research to understand whether Solosec (secnidazole) is safe to take during pregnancy. This medication hasn’t been well-studied in human pregnancies, but animal studies suggest it's unlikely to cause harm. If you're pregnant, please talk with your gynecologist to see whether Solosec (secnidazole) is a good option for you.
Solosec (secnidazole) and metronidazole (Flagyl, Vandazole) are oral nitroimidazole antibiotics that can treat BV and trich, but they're not the same. One main difference is that metronidazole (Flagyl, Vandazole) is a first-choice treatment for both BV and trich, while Solosec (secnidazole) isn't. This is because Solosec (secnidazole) is higher-cost and there aren't enough long-term studies to understand how it compares with existing treatments. Another difference is the length of treatment. While treatment with Solosec (secnidazole) is only one dose, treatment with metronidazole (Flagyl) can take multiple days (typically 5 to 7 days). Talk with your healthcare team if you have more questions about either medication.
Don't drink alcohol or eat foods containing large amount of ethanol or propylene glycol (food additives), such as salad dressing, dried soup or cake mix, during treatment with and for at least 2 days after taking Solosec (secnidazole). Doing so can cause nausea, vomiting, diarrhea, belly pain, dizziness, and headache.
People who took Solosec (secnidazole) have commonly reported vaginal yeast infections. This is because Solosec (secnidazole) kills not only the bad bacteria that cause BV and trich, but it also kills the good bacteria that keep your vagina healthy. When the good bacteria is gone, Candida (a type of yeast) can overgrow and cause a vaginal yeast infection. Talk with your healthcare team if you think you might have a yeast infection and they can talk with you about treatment options.
Solosec (secnidazole) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Taking Solosec (secnidazole) can raise your risk of getting a vaginal yeast infection. If so, your healthcare team might prescribe a medication to treat the yeast infection. Please talk with your gynecologist if you notice your vagina is red and itchy, you have thick white vaginal fluid, or if you experience pain or burning when you urinate.
Taking Solosec (secnidazole) more often or differently than prescribed can put you at risk for infections that are harder to treat in the future. To make sure that this medication will work well to fight future infections, follow your gynecologist's instruction on when and how long to take Solosec (secnidazole).
It’s not clear whether or not taking Solosec (secnidazole) for a long time can put you at risk for cancer. Studies show that rats who took metronidazole (Flagyl) (a medication that’s similar to Solosec (secnidazole)) throughout their lifetime were at higher risk for tumors. If you're taking Solosec (secnidazole), don't take this medication more often than what your gynecologist has directed.
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 2g | 1 packet | $186.74 | $186.74 |
Each packet contains 2 grams of Solosec (secnidazole) granules.
Bacterial vaginosis and Trichomoniasis
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Solosec (secnidazole) will not be safe for you to take.