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Sofdra

Sofdra Side Effects

Zunaira Iftikhar, PharmD CandidateDaisy Chau, PharmD
Reviewed by Zunaira Iftikhar, PharmD Candidate, Daisy Chau, PharmD, Cydnee Ng, PharmD
Last reviewed on March 7, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth (14%)
  • Blurred vision (9%)
  • Application site irritation (e.g., pain, redness, inflammation, itching) (up to 8%)
  • Dilated pupils (7%)

Less Common Side Effects

  • Difficulty urinating
  • Dry eyes
  • Upper respiratory tract infection
  • Flu
  • Headaches

Source: FDA

The following Sofdra side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Burning, itching, crusting, or peeling of treated skin
  • Fever that does not go away, decreased sweating
  • Trouble passing urine

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Blurry vision
  • Burning or pain at application site
  • Dilated pupils
  • Dry mouth
  • Headache
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