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Pyzchiva
Used for Crohn's Disease, Plaque Psoriasis, Psoriatic Arthritis, Ulcerative Colitis
Used for Crohn's Disease, Plaque Psoriasis, Psoriatic Arthritis, Ulcerative Colitis
Pyzchiva (ustekinumab or ustekinumab-ttwe) is a biosimilar to Stelara (ustekinumab) and is FDA-approved to treat the same autoimmune conditions, including psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It works by blocking certain proteins called interleukins that cause inflammation in the body. The medication is usually given as an injection under the skin. After a few starting doses, you'll take a dose every 8 or 12 weeks depending on your condition. Common side effects include headache, feeling tired, and having common cold symptoms.
What is Pyzchiva (ustekinumab)?
What is Pyzchiva (ustekinumab) used for?
- Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
- Psoriatic arthritis (PsA) - adults and children 6 years and older
- Moderate-to-severe Crohn's disease (CD) - adults only
- Moderate-to-severe ulcerative colitis (UC) - adults only
How Pyzchiva (ustekinumab) works
Pyzchiva (ustekinumab) is an interleukin antagonist. It works by blocking two proteins in your immune system — interleukin-12 (IL-12) and interleukin-23 (IL-23) — that play a major role in inflammation. By targeting these proteins, the medication helps to lower inflammation and relieve symptoms from autoimmune conditions.
Drug facts
| Common Brands | Pyzchiva |
|---|---|
| Drug Class | IL-12 and IL-23 antagonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Pyzchiva (ustekinumab)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Plaque psoriasis:
- Common cold symptoms (7-8%)
- Upper respiratory tract infection (4-5%)
- Headache (5%)
Psoriatic arthritis:
- Joint pain (3%)
- Nausea (3%)
Crohn's disease:
- Common cold symptoms (11%)
- Redness at the injection site (5%)
- Yeast infection (5%)
- Bronchitis (5%)
Ulcerative colitis:
- Common cold symptoms (24%)
- Headache (10%)
- Stomach pain (7%)
- Flu infection (6%)
- Fever (5%)
Less Common Side Effects
- Dizziness
- Diarrhea
- Back pain
- Muscle pain
- Depression
- Sore throat
- Itchiness
- Vomiting
Pyzchiva (ustekinumab) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious infection: fever, muscle aches, cough, trouble breathing, weight loss, sores on the body, diarrhea, stomach pain, problems with urination, tiredness
- Severe allergic reaction: feeling faint, facial swelling, chest tightness, rash
- Brain condition: headache, confusion, vision problems, seizures
- Lung conditions: trouble breathing, cough
The following Pyzchiva (ustekinumab) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry cough, shortness of breath or trouble breathing
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Sudden and severe headache, confusion, change in vision, seizures, which may be signs of posterior reversible encephalopathy syndrome (PRES)
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Dizziness
- Fatigue
- Headache
- Pain, redness, or irritation at injection site
- Runny or stuffy nose
- Sore throat
Get your GoodRx coupon
N/A
GoodRx discount
$1998.25
Pros and cons of Pyzchiva (ustekinumab)
Pros
- Biosimilar that's interchangeable with Stelara (ustekinumab)
- Syringes can be stored at room temperature for up to 35 days
- Approved for children as young as 6 years old for certain conditions
- Stopper isn't made of natural rubber latex
Cons
- Can weaken your immune system and raise your risk of infection
- Potential to cause serious allergic reactions
- For CD and UC, the first dose must be given as an IV infusion
- Can't receive live vaccines while taking this medication
Pharmacist tips for Pyzchiva (ustekinumab)
- Mark your injection dates on a calendar. You don’t use Pyzchiva (ustekinumab) very often, so it can be easy to forget. Keeping track helps you stay on schedule.
- Inject Pyzchiva (ustekinumab) under the skin in your upper arms, thighs, buttocks, or stomach area. Pick a new spot each time to avoid skin irritation. Don’t inject into skin that’s red, bruised, sore, or hard.
- Get medical help right away if you have signs of a serious allergic reaction after using Pyzchiva (ustekinumab). These might include swelling of the face or throat, trouble breathing, or a rash.
- Pyzchiva (ustekinumab) can weaken your immune system, making it harder to fight infections. Let your prescriber know if you have symptoms of an infection, such as a fever, cough, tiredness, muscle aches, or stomach pain.
- Contact your care team right away if you notice symptoms like headache, confusion, vision problems, or seizures. These could be signs of a rare brain condition linked to Pyzchiva (ustekinumab).
- Pyzchiva (ustekinumab) can affect how your body responds to vaccines. Avoid live vaccines during treatment. Talk to your prescriber before getting any type of vaccine.
- Store Pyzchiva (ustekinumab) in its original carton in the refrigerator. If you're using the prefilled syringes, you can keep them at room temperature (up to 30°C or 86°F) for up to 35 days. If you’re using a vial, it should stay refrigerated until it’s time for your dose.
How to inject Pyzchiva (ustekinumab) from a prefilled syringe:
- Make sure you know how to inject Pyzchiva (ustekinumab) the right way. Ask your prescriber or pharmacist if you have questions.
- Clean the spot on your skin with an alcohol wipe before you inject to help prevent infection.
- When you're ready to inject, take off the needle cover from the syringe. Hold the syringe with one hand and pinch the cleaned skin with the other.
- Insert the needle into the pinched skin at about a 45-degree angle and push the plunger down with your thumb until all the liquid is injected. Then take out the needle and let go of your skin.
- Put the syringe into a sharps container. Never throw used syringes into the regular trash since it could harm someone.
Risks and warnings for Pyzchiva (ustekinumab)
Pyzchiva (ustekinumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Infections
- Risk factors: Active, chronic, or recurrent infection | People with certain genetic mutations | Taking other medications that weaken your immune system
Pyzchiva (ustekinumab) can raise your risk of infections, including serious ones that might need hospital care. These can be caused by bacteria, viruses, or fungi. Tell your prescriber about your medical history before starting Pyzchiva (ustekinumab), especially if you've ever had tuberculosis (TB). Let your care team know right away if you have signs of infection, such as fever, chills, cough, or tiredness — your treatment might need to be paused until you recover.
Cancers
- Risk factors: Older adults | Taking other medications that weaken your immune system | History of skin cancer
Pyzchiva (ustekinumab) weakens your immune system and can raise your risk of certain cancers. Some people developed skin cancer while taking this medication, especially those with a higher risk. Your care team will check your skin regularly during treatment, particularly if you have a history of cancer or other risk factors. Let your prescriber know if you’ve had cancer before or if you notice any new or changing spots on your skin.
Severe allergic reaction
Serious allergic reactions, including anaphylaxis and angioedema, have been reported with Pyzchiva (ustekinumab). If you have a severe reaction, your care team will stop the medication and treat you right away. Get medical help immediately if you have symptoms like trouble breathing, swelling of your face or throat, or a serious rash.
Brain condition
Rare cases of a brain condition called posterior reversible encephalopathy syndrome (PRES) have been reported in people taking Pyzchiva (ustekinumab). Symptoms can include headache, seizures, confusion, or vision changes. These symptoms can appear anywhere from a few days to months after starting the medication, sometimes even after a year or more. If you have PRES, your care team will stop the medication and provide treatment. Let your prescriber know right away if you notice any of these signs.
Vaccines
Before starting Pyzchiva (ustekinumab), you or your child should be up to date on all recommended vaccines. While you're being treated, avoid getting live vaccines. You should also avoid the BCG vaccine during treatment, as well as for one year before starting and one year after stopping the medication. Be careful if someone in your household gets a live vaccine since it can spread and pose a risk to you. Non-live vaccines are generally safe, but they might not work as well while you're taking Pyzchiva (ustekinumab). Check with your care team before getting any vaccines during treatment.
Lung problems
Different types of pneumonia have been reported in people taking Pyzchiva (ustekinumab), and in some cases, these conditions were serious. Symptoms can include cough and trouble breathing. Let your care team know right away if you have new or worsening breathing problems. You might have to stop taking the medication and receive the appropriate treatment.
Pyzchiva (ustekinumab) dosage
The average cost for 1 syringe of 1ml of 90mg/ml of Pyzchiva (ustekinumab) is $4,015.63 with a free GoodRx coupon. This is 18.18% off the average retail price of $4,907.71. 
Autoinjector
Syringe
Vial
Autoinjector| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.5ml of 45mg/0.5ml | 1 autoinjector | $1,998.25 | $1,998.25 |
| 1ml of 90mg/ml | 1 autoinjector | $3,990.25 | $3,990.25 |
Syringe| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.5ml of 45mg/0.5ml | 1 syringe | $2,010.93 | $2,010.93 |
| 1ml of 90mg/ml | 1 syringe | $4,015.63 | $4,015.63 |
Vial| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.5ml of 45mg/0.5ml | 1 vial | $2,010.93 | $2,010.93 |
Typical dosage for Pyzchiva (ustekinumab)
Plaque psoriasis
- Adults:
- Weight 220 lbs or less: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Weight more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
- Children ages 6 and older:
- Weight less than 132 lbs: The typical dose is 0.75 mg/kg of body weight injected under the skin once, then another 0.75 mg/kg four weeks later. After the second dose, 0.75 mg/kg is injected every 12 weeks.
- Weight of 132 lbs to 220 lbs: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Weight more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
Psoriatic arthritis
- Adults:
- Psoriatic arthritis only: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Psoriatic arthritis with plaque psoriasis and weighing more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
- Children ages 6 and older:
- Weight less than 132 lbs: The typical dose is 0.75 mg/kg of body weight injected under the skin once, then another 0.75 mg/kg four weeks later. After the second dose, 0.75 mg/kg is injected every 12 weeks.
- Weight of 132 lbs or more: The typical dose is 45 mg injected under the skin once, then another 45 mg four weeks later. After the second dose, 45 mg is injected every 12 weeks.
- Psoriatic arthritis with plaque psoriasis and weighing more than 220 lbs: The typical dose is 90 mg injected under the skin once, then another 90 mg four weeks later. After the second dose, 90 mg is injected every 12 weeks.
Crohn's disease and ulcerative colitis:
- Adults:
- Weight less than 121 lbs: The typical dose is 260 mg infused into the veins once, then 90 mg injected under the skin every 8 weeks.
- Weight of 121 lbs to 187 lbs: The typical dose is 390 mg infused into the veins once, then 90 mg injected under the skin every 8 weeks.
- Weight more than 187 lbs: The typical dose is 520 mg infused into the veins once, then 90 mg injected under the skin every 8 weeks.
How much does Pyzchiva (ustekinumab) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Ustekinumab-ttwe (Pyzchiva) (brand)
$1,998.25
What are alternatives to Pyzchiva (ustekinumab)?
There are a number of medications that your doctor can prescribe in place of Pyzchiva (ustekinumab). Compare a few possible alternatives below.
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