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Pliaglis

Pliaglis Side Effects

Sarah Lobello Pearson, PharmDAllison Gourley, PharmD
Reviewed by Sarah Lobello Pearson, PharmD, Allison Gourley, PharmD
Last reviewed on May 25, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Skin redness (47%)
  • Changes in skin color (16%)
  • Swelling (14%)

Less Common Side Effects

  • Rash
  • Itching
  • Dry skin
  • Headache
  • Dizziness
  • Fever

Pliaglis serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Blood problems (methemoglobinemia): bluish coloring of skin, headache, trouble breathing, tiredness, seizures, coma
  • Severe allergic reaction: rash, hives, swelling, dizziness, trouble breathing

Source: DailyMed

The following Pliaglis side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Headache, unusual weakness or fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, blue skin or lips, which may be signs of methemoglobinemia
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Change in skin color
  • Irritation at application site
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