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Lidocaine OTC

Lidocaine OTC Side Effects

Connie Zheng, PharmDAshley Wong, PharmD
Reviewed by Connie Zheng, PharmD, Ashley Wong, PharmD
Last reviewed on May 15, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

The side effects below only apply to lidocaine 5% ointment and LiDORx (lidocaine) 3% gel:

  • Lightheadedness
  • Dizziness
  • Feeling sleepy and tired
  • Ringing in the ears
  • Blurry or double vision
  • Vomiting
  • Feeling hot, cold, or numb
  • Twitching, shaking
  • Seizures
  • Coma
  • Trouble breathing
  • Slow heart rate
  • Low blood pressure

Less Common Side Effects

The side effects below only apply to lidocaine 5% ointment and LiDORx (lidocaine) 3% gel:

  • Nervousness
  • Overwhelming feeling of happiness and joy
  • Feeling confused

Lidocaine OTC serious side effects

Contact your healthcare provider immediately if you experience any of the following.

The side effects below only apply to lidocaine 5% ointment and LiDORx (lidocaine) 3% gel:

  • Blood problems (methemoglobinemia): Seizures, loss of consciousness, fast heart beat, trouble breathing, feeling dizzy or faint, feeling tired, skin color turning blue
  • Too much lidocaine in your body: Drowsiness, confusion, slow heart beat, trouble breathing, difficulty controlling muscle movements
  • Serious allergic reactions: Swelling of the face, difficulty breathing, trouble speaking, throat tightening up, red and itchy rash, lightheadedness, clammy skin
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Source: DailyMed

The following Lidocaine OTC side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Blistering, crusting, irritation, itching, or reddening of the skin

cough

cracked, dry, or scaly skin

fast heartbeat

fever

hives or welts, itching, skin rash

hoarseness

irritation

joint pain, stiffness, or swelling

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

noisy breathing

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

trouble breathing or swallowing

Incidence not known

Blistering, bruising, burning, discoloration, itching, redness, or swelling at the application site

bluish-colored lips, fingernails, or palms

blurred vision

chest pain or discomfort

cold, clammy, or pale skin

confusion

dark urine

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness or dizziness

false or unusual sense of well-being

fear or nervousness

headache

irregular, fast or slow, or shallow breathing

loss of consciousness

no blood pressure or pulse

pale or blue lips, fingernails, or skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid heart rate

seizures

shakiness in the legs, arms, hands, or feet

slow or irregular heartbeat

sore throat

stopping of the heart

trembling or shaking of the hands or feet

twitching

unusual bleeding or bruising

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Bad, unusual, or unpleasant (after) taste

change in taste

cold or numbness

confusion about identity, place, and time

continuing ringing or buzzing or other unexplained noise in the ears

double vision

hearing loss

heat sensation

lack or loss of strength

metallic taste

sleepiness or unusual drowsiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.
Ashley Wong, PharmD, is a licensed pharmacist in California. She has over 6 years of experience providing drug information.

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