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Lidocaine/Prilocaine

Lidocaine/Prilocaine Side Effects

Kristianne Hannemann, PharmDCydnee Ng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Cydnee Ng, PharmD
Last reviewed on September 30, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Paleness (skin turning white, 37% on unbroken skin)
  • Skin redness (30% on unbroken skin, 21% on genital mucosa)
  • Burning sensation (17% on genital mucosa)
  • Swelling (6% on unbroken skin, 10% on genital mucosa)
  • Change in temperature sensations (7% on unbroken skin)
  • Itching (2% on unbroken skin)
  • Rash (fewer than 1% on unbroken skin)

Less Common Side Effects

The following side effects can occur if too much [[EDITOR|DRUG_DISPLAY_NAME]] is absorbed into your body:

  • Lightheadedness
  • Nervousness
  • Feeling excited
  • Confusion
  • Dizziness
  • Drowsiness
  • Ringing in the ears
  • Blurred or double vision
  • Vomiting
  • Twitching
  • Tremors
  • Seizures
  • Unconsciousness (not responding to sound or touch)
  • Shallow or stopped breathing

Lidocaine/Prilocaine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction: trouble breathing, swelling, low blood pressure, rash
  • Methemoglobinemia: blue or gray skin color, seizures, coma, changes in heart rate or rhythm
When do Lidocaine/Prilocaine possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Paleness
Skin redness
Swelling
Change in temperature sensations
Burning sensation
Itching

Source: DailyMed

The following Lidocaine/Prilocaine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Cough

difficulty with swallowing

large, hive-like swellings on the eyelids, face, lips, tongue, or genitals

severe dizziness or feeling faint

skin rash, itching, or hives

stuffy nose

tightness in the chest

troubled breathing

Incidence not known

Blisters on the skin at application site

blue or blue-purple color of lips, fingernails, mouth, or skin

blurred or double vision

dark urine

dizziness or drowsiness

fainting

feeling hot, cold, or numb

headache

irregular or fast heartbeat

muscle twitching or trembling

nausea

ringing or buzzing in the ears

seizures

unusual excitement, nervousness, or restlessness

unusual tiredness or weakness

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning, swelling, itching, or skin rash at application site

white or red skin at the application site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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