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Opdivo

Opdivo Dosage

Allison Baxley, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Allison Baxley, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on December 3, 2025

Typical dosage for Opdivo

Opdivo is given as an intravenous (IV) infusion. This means it's given as an infusion through a vein.

Your dose depends on the type of cancer you have and sometimes your weight. Your oncologist will determine the dose for you.

  • When Opdivo is given by itself

    • Most times: The typical dose is 240 mg IV every 2 weeks, or 480 mg IV every 4 weeks.
    • For children 12 years and older weighing less than 88 lbs (melanoma or colorectal cancer only): The dose is based on weight. The typical dose is 3 mg/kg IV every 2 weeks, or 6 mg/kg IV every 4 weeks.
  • When Opdivo is given with other cancer therapies

    • Your Opdivo dose depends on your personal treatment plan and your other cancer medications. For example, your dose might be 360 mg, 1 mg/kg, or 3 mg/kg IV every 3 weeks when given with Yervoy (ipilimumab).

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