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Doxorubicin Coupon - Doxorubicin 25ml of 2mg/ml vial

doxorubicin

Generic Doxil
Used for Leukemia, Multiple Myeloma, Hodgkin Lymphoma, Lung Cancer, Breast Cancer, Ovarian Cancer, Stomach Cancer, Soft Tissue Sarcoma, Thyroid Cancer, Kaposi's Sarcoma, Neuroblastoma
Used for Leukemia, Multiple Myeloma, Hodgkin Lymphoma, Lung Cancer, Breast Cancer, Ovarian Cancer, Stomach Cancer, Soft Tissue Sarcoma, Thyroid Cancer, Kaposi's Sarcoma, Neuroblastoma

Liposomal doxorubicin (Doxil) is used to treat certain cancers in adults. They include ovarian cancer, multiple myeloma, and Kaposi’s sarcoma related to human immunodeficiency virus (HIV). It’s a type of chemotherapy medication called an anthracycline. This medication is given as an intravenous (IV) infusion at a medical office or infusion clinic, usually once every 3 or 4 weeks. Liposomal doxorubicin (Doxil) can be given by itself or together with other anticancer medications, depending on your treatment plan. Side effects of liposomal doxorubicin (Doxil) include nausea, infusion reactions, and hand-foot syndrome.

Reviewed by:
reviewer
Allison Baxley, PharmD, BCOP
reviewer
Cydnee Ng, PharmD
Last reviewed on January 30, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsContraindicationsImagesReferencesPricesMedicare
basics-icon

What is Liposomal doxorubicin (Doxil)?

What is Liposomal doxorubicin (Doxil) used for?

How Liposomal doxorubicin (Doxil) works

Liposomal doxorubicin (Doxil) is a chemotherapy medication known as an anthracycline. It works by damaging the DNA in the cells in the body that grow very fast, including cancer cells. Cells with damaged DNA can’t grow or spread as well, which helps treat cancer.

Are you looking for information on conventional doxorubicin (Adriamycin) instead?

Drug Facts

Common BrandsDoxil
Drug ClassAnthracycline
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Liposomal doxorubicin (Doxil)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Hair loss
  • Sore throat
  • Shortness of breath
  • Cough
  • Back pain
  • Infection
  • Indigestion
  • Headache
  • Dizziness
  • Low blood cell count
Note: Side effects data from clinical studies of people with ovarian cancer. Side effects might differ for people with HIV-related Kaposi’s sarcoma or multiple myeloma.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Heart problems: heart failure, trouble breathing, swelling in the legs or belly, severe fatigue, sudden weight gain
  • Infusion reactions: headache, chills, flushing, chest pain, trouble breathing, itching, fast heart beat, low blood pressure
  • Infection: fever, chills, muscle aches, cough, trouble breathing, tiredness

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Cough or hoarseness accompanied by fever or chills

darkening or redness of the skin (if you recently had radiation treatment)

fast or irregular heartbeat

fever or chills

joint pain

lower back or side pain accompanied by fever or chills

pain at the injection site

painful or difficult urination accompanied by fever or chills

red streaks along the injected vein

shortness of breath

stomach pain

swelling of the feet and lower legs

Rare

Black, tarry stools

blood in the urine

pinpoint red spots on the skin

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Hair loss, thinning of hair

nausea and vomiting

sores in the mouth and on the lips

Less common

Darkening of the soles, palms, or nails

diarrhea

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Fast or irregular heartbeat

shortness of breath

swelling of the feet and lower legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Liposomal doxorubicin (Doxil)

thumbs-up

Pros

Is a part of a recommended treatment regimen for ovarian cancer

Has a lower risk of heart problems than other anthracyclines

Given every 3 or 4 weeks, depending on the treatment plan for your cancer

thumbs-down

Cons

Given as an infusion through a vein, so requires a needle

Commonly causes nausea and a skin condition called hand-foot syndrome

Can cause bothersome infusion reactions

pharmacist-tips

Pharmacist tips for Liposomal doxorubicin (Doxil)

pharmacist

  • Let your oncology team know if you have symptoms like headache, chills, flushing, chest pain, trouble breathing, itching, or a racing heart while you’re getting your liposomal doxorubicin (Doxil) infusion. These can be infusion reactions. And your oncology team can give you medications to help manage and relieve them.

    • Tell your nurse right away if you feel any pain, burning, or warmth during your liposomal doxorubicin (Doxil) infusion. Some of the medication might leak from the vein and reach healthy tissue nearby, causing pain. Your nurse might stop the infusion or place cold compresses to help.

      • Liposomal doxorubicin (Doxil) commonly causes nausea and vomiting. Your oncologist will prescribe antiemetic medications, like ondansetron (Zofran) or prochlorperazine, for you. You can take these at home if you feel nauseous between your infusions. Call your oncology team if any nausea or vomiting bothers you too much or gets severe.

        • Hand-foot syndrome is a very common skin problem that can happen with liposomal doxorubicin (Doxil). Prevent hand-foot syndrome by avoiding hot water when you wash your hands and shower. Also use a daily mild moisturizer on your hands and feet. Wear soft socks and house slippers when possible and avoid tight footwear that might rub your feet. Ask your oncology team for more ways to prevent and manage this side effect.

          • Avoid getting sick by washing your hands often, avoiding crowds, and washing raw fruits and vegetables thoroughly before you eat them. Liposomal doxorubicin (Doxil) can sometimes make your white blood cell count drop. This can make it hard for you to fight off infections as well if you get sick.

            • Some people might have some hair thinning or hair loss while they’re taking liposomal doxorubicin (Doxil), even though it’s usually less than with doxorubicin (Adriamycin). Most times, hair will grow back after you stop chemotherapy. Let your care team know If you notice hair loss during treatment with liposomal doxorubicin (Doxil). They can discuss with you about ways to manage this side effect.

              • If you or your partner can get pregnant and you’re sexually active, be sure to use birth control while you’re taking liposomal doxorubicin (Doxil) and for 6 months after your treatment ends. This medication has a risk of harm to an unborn baby. Let your oncologist know right away if you or your partner becomes pregnant.

                faqs

                Frequently asked questions about Liposomal doxorubicin (Doxil)

                Is liposomal doxorubicin (Doxil) chemotherapy?
                Yes, liposomal doxorubicin (Doxil) is a type of chemotherapy called an anthracycline. It works by damaging the DNA in cancer cells. This causes the cancer cells to die, which helps treat cancer.
                Is liposomal doxorubicin (Doxil) the same as doxorubicin (Adriamycin)?
                Not exactly. Liposomal doxorubicin (Doxil) and doxorubicin (Adriamycin) contain the same active ingredient. They both cause DNA damage to kill cancer cells. But they’re used to treat different cancers. In addition, liposomal doxorubicin (Doxil) is made in a way that makes it last longer in the body and get to cancer cells better than doxorubicin (Adriamycin). Some side effects of liposomal doxorubicin (Doxil), such as nausea and low blood cell counts, are similar to that of doxorubicin (Adriamycin). But hand-foot syndrome is a unique side effect of liposomal doxorubicin (Doxil). Speak with your oncologist about whether liposomal doxorubicin (Doxil) or doxorubicin (Adriamycin) might be right for you.
                What’s the most common side effect of liposomal doxorubicin (Doxil)?
                One of the most common side effects of liposomal doxorubicin (Doxil) is hand-foot syndrome (HFS). This is a side effect that affects the skin. It causes redness, itching, and sometimes pain on the palms of the hands and soles of the feet. Try to avoid hot water when you shower or wash your hands, and use a mild moisturizer every day. Tell your oncology team if you have a rash or feel pain, tingling, or itching on your hands and feet. They can recommend ways to manage this side effect, such as certain creams, cold compresses, or a change to your treatment plan.
                Does liposomal doxorubicin (Doxil) cause infusion reactions?
                Yes, liposomal doxorubicin (Doxil) can sometimes cause infusion reactions. As the name suggests, these reactions can happen during your infusion. They can include headache, lightheadedness, chills, flushing, chest pain, itchiness, and trouble breathing. In most cases, infusion reactions happen during the first infusion of the medication you get. Your oncology team will have treatment ready in case you have a reaction during your infusion.
                What is the most serious side effect of liposomal doxorubicin (Doxil)?
                Some side effects of liposomal doxorubicin (Doxil) that can become serious include low white blood cell counts and heart problems. A low white blood cell count puts you at risk for infections because your body can’t fight them well if you get sick. These infections can be serious or even life-threatening. And although it’s not common, some people taking liposomal doxorubicin (Doxil) have had serious heart problems like heart failure. Keep in mind that everyone can have a different experience with liposomal doxorubicin (Doxil). These side effects might not happen to every person and they don’t always become serious. Speak with your oncologist if you have concerns about serious side effects from this medication.
                Does liposomal doxorubicin (Doxil) cause nephrotoxicity?
                No. Liposomal doxorubicin (Doxil) isn’t known to cause nephrotoxicity (kidney problems) in people. Talk to your oncologist if you have kidney problems and you’re worried about taking liposomal doxorubicin (Doxil).
                Can I take liposomal doxorubicin (Doxil) if I have heart problems?
                Talk to your oncologist about whether it’s safe for you to take liposomal doxorubicin (Doxil) if you have heart problems. Liposomal doxorubicin (Doxil) can sometimes cause heart problems such as congestive heart failure, though it’s uncommon. They’ll check your heart function using an echocardiogram (ECHO) to see whether you’re at risk for worsening heart problems with treatment. Your oncologist will discuss with you about the risks and benefits of taking liposomal doxorubicin (Doxil).
                Is liposomal doxorubicin (Doxil) a vesicant?
                No, liposomal doxorubicin (Doxil) isn’t a vesicant. Instead, it’s an irritant. This means that it might be painful if the medication leaks from the vein and gets in contact with healthy tissue nearby. Your care team will try to prevent pain from this type of leakage by giving liposomal doxorubicin (Doxil) through an intravenous access device such as a port. But tell your nurse right away if you feel any pain, burning, or warmth during your liposomal doxorubicin (Doxil) infusion. Your nurse might stop your infusion or use cold compresses to help relieve the pain.
                What is the cumulative lifetime dose of liposomal doxorubicin (Doxil)?
                Your “cumulative lifetime dose” of liposomal doxorubicin (Doxil), or the total amount of the medication you can take in your life, might be specific to you. It depends on the type of cancer you have, the previous treatments you’ve had, and the risk factors for heart problems that you have. It’s important for your oncologist to keep track of your cumulative dose because liposomal doxorubicin (Doxil) can cause heart problems. Typically, oncologists will avoid giving you more than a certain cumulative dose to protect you from developing heart problems. Here’s an example of calculating the cumulative dose: after you’ve taken a dose of 50 mg/m2 for three doses so far, your cumulative dose is 150 mg/m2. Speak with your oncologist to learn more about your specific cumulative lifetime dose of liposomal doxorubicin (Doxil).
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                warings-icon

                What are the risks and warnings for Liposomal doxorubicin (Doxil)?

                Liposomal doxorubicin (Doxil) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Serious heart problems

                • Risk factors: Radiation to the chest | Previous treatment with anthracycline chemotherapy | History of heart failure

                  Although uncommon, liposomal doxorubicin (Doxil) can cause serious heart problems, such as heart rhythm problems and heart failure. Because of this risk, you’ll need to get a heart scan called an echocardiogram (ECHO) before you start treatment to make sure it’s safe. There’s also a limit for how much of the medication each person can take in their lifetime, which helps lower the risk of heart problems.

                  Talk to your oncologist before you start liposomal doxorubicin (Doxil) about whether it’s safe for you to take the medication if you have heart problems. It’s uncommon to have symptoms, but still look out for shortness of breath, swelling in the feet or belly, sudden weight gain, and tiredness.

                  risk-warning

                  Infusion reactions

                  Some people who take liposomal doxorubicin (Doxil) can have serious and sometimes life-threatening infusion reactions. It might cause symptoms like headache, chills, flushing, chest pain, trouble breathing, itching, fast heart beat, and low blood pressure.

                  Most times, infusion reactions happen during the first dose of liposomal doxorubicin (Doxil). So, your oncology team will start off giving your infusion at a slow rate. They’ll give your next infusions faster only if you can tolerate the infusions without a reaction.

                  Your oncology team will have treatment readily available in case you have a reaction while you’re getting your liposomal doxorubicin (Doxil) infusion. They’ll pause your infusion while they help you to manage the reaction. You might need to get the rest of your infusions at a slower infusion rate. If you have a serious or life-threatening reaction, you’ll probably need to stop taking liposomal doxorubicin (Doxil) altogether.

                  risk-warning

                  Hand-foot syndrome

                  Many people who take liposomal doxorubicin (Doxil) develop a skin condition called hand-foot syndrome (HFS). It can cause redness, itching, and sometimes pain or tingling on the palms of the hands and soles of the feet. Symptoms usually appear after the first 2 or 3 cycles of treatment, but they can happen sooner.

                  Let your oncologist know if you have a rash or feel pain, tingling, or itchiness on your hands and feet. Your care team might recommend ways to manage it, such as certain creams, cold compresses, and protective gloves. Your oncologist might pause treatment or lower your dose of liposomal doxorubicin (Doxil). You might need to stop taking the medication altogether if your symptoms are severe enough that it makes daily activities like walking or holding things difficult.

                  risk-warning

                  Possible new cancers in the mouth

                  Although rare, people who took liposomal doxorubicin (Doxil) for more than a year have developed new cancers in the mouth. These people were diagnosed with this new cancer while they were taking liposomal doxorubicin (Doxil) and up to 6 years after they stopped treatment.

                  Your oncologist and your dentist will check for signs of cancer in your mouth, such as pain or mouth sores, at your follow-up visits. It’s important to remember that liposomal doxorubicin (Doxil) can cause mouth sores as a side effect, which is different from mouth cancer. Contact your oncologist if you have any soreness or irritation in the mouth or throat, a lump in the neck, or trouble swallowing or speaking during treatment or even years after you’ve completed treatment.

                  risk-warning

                  Harm to unborn baby

                  Based on animal studies and the way the medication works, liposomal doxorubicin (Doxil) has a risk of causing harm to an unborn baby or miscarriage if it’s given during pregnancy. It’s important to avoid taking liposomal doxorubicin (Doxil) during pregnancy, especially in the first trimester.

                  Before taking liposomal doxorubicin (Doxil), your oncologist might ask that you take a pregnancy test. This test is used to confirm that you’re not pregnant when you start treatment.

                  If you or your partner can become pregnant and you’re sexually active, use effective birth control while you’re getting treated with liposomal doxorubicin (Doxil). Continue using birth control for 6 months after your last dose. Let your oncology team know right away if you or your partner becomes pregnant while you’re taking liposomal doxorubicin (Doxil).

                  dosage

                  Liposomal doxorubicin (Doxil) dosage forms

                  Typical dosing for Liposomal doxorubicin (Doxil)

                  Liposomal doxorubicin (Doxil) is given by a healthcare professional as an intravenous (IV) infusion. The dose is based on your body surface area (BSA), which takes into account your height and weight.

                  • Ovarian cancer: The recommended dose is 50 mg/m2 IV once every 4 weeks.

                  • HIV-related Kaposi’s sarcoma: The recommended dose is 20 mg/m2 IV once every 3 weeks.

                  • Multiple myeloma: The recommended dose is 30 mg/m2 IV on day 4 of each 21-day treatment cycle. You’ll get your liposomal doxorubicin (Doxil) infusion along with an infusion of Velcade (bortezomib) on the same day.

                  interactions

                  Interactions between Liposomal doxorubicin (Doxil) and other drugs

                  Liposomal doxorubicin (Doxil) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Liposomal doxorubicin (Doxil). Please note that only the generic name of each medication is listed below.

                  Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

                  Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                  • Atazanavir
                  • Boceprevir
                  • Cobicistat
                  • Lopinavir
                  • Measles Virus Vaccine, Live
                  • Mumps Virus Vaccine, Live
                  • Nelfinavir
                  • Rotavirus Vaccine, Live
                  • Rubella Virus Vaccine, Live
                  • Saquinavir
                  • Tasonermin
                  • Telaprevir
                  • Varicella Virus Vaccine, Live
                  • Zoster Vaccine, Live

                  Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                  Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                  contraindications-icon

                  Liposomal doxorubicin (Doxil) contraindications

                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Liposomal doxorubicin (Doxil) will not be safe for you to take.
                  images

                  Liposomal doxorubicin (Doxil) images

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                  References

                  Best studies we found

                  Alberts, D. S. (1997). A safety review of pegylated liposomal doxorubicin in the treatment of various malignancies. Oncology.

                  American Cancer Society. (2018). What is ovarian cancer?

                  American Cancer Society. (2019). How chemotherapy drugs work.

                  View All References (24)

                  American Cancer Society. (2023). What to do for mouth sores.

                  American Cancer Society. (2024). Infusion or immune reactions.

                  American Cancer Society. (2024). Mouth soreness and pain.

                  American Cancer Society. (2024). Neutropenia (low white blood cell counts).

                  American Cancer Society. (2025). What is multiple myeloma?

                  Armstrong, D. K., et al. (2022). NCCN Guidelines® Insights: Ovarian cancer, Version 3.2022. Journal of the National Comprehensive Cancer Network.

                  Boschi, R., et al. (2012). Extravasation of antineoplastic agents: Prevention and treatments. Pediatric Reports.

                  Centers for Disease Control and Prevention. (n.d.). What you need to know: Neutropenia and risk for infection.

                  Chatterjee, K., et al. (2010). Doxorubicin cardiomyopathy. Cardiology.

                  Gonçalves, P. H., et al. (2017). HIV-associated Kaposi sarcoma and related diseases. AIDS.

                  Green, A. E., et al. (2006). Pegylated liposomal doxorubicin in ovarian cancer. International Journal of Nanomedicine.

                  Kwakman, J. J. M., et al. (2020). Management of cytotoxic chemotherapy-induced hand-foot syndrome. Oncology Reviews.

                  Lorusso, D., et al. (2007). Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia (‘hand-food’ syndrome). Annals of Oncology.

                  National Cancer Institute. (n.d.). Anthracycline.

                  National Cancer Institute. (n.d.). Extravasation.

                  National Cancer Institute.(n.d.). Hand-foot syndrome.

                  National Cancer Institute. (n.d.). Port.

                  National Comprehensive Cancer Network. (2025). Anemia and neutropenia: Low red and white blood cell counts.

                  National Institute of Dental and Craniofacial Research. (2024). Oral cancer.

                  NorthStar RxLLC. (2024). Doxorubicin hydrochloride injectable, liposomal [package insert]. DailyMed.

                  Palich, R., et al. (2021). Kaposi's sarcoma in virally suppressed people living with HIV: An emerging condition. Cancers.

                  Rafiyath, S. M., et al. (2012). Comparison of safety and toxicity of liposomal doxorubicin vs. conventional anthracyclines: A meta-analysis. Experimental Hematology & Oncology.

                  Thorn, C. F., et al. (2011). Doxorubicin pathways: Pharmacodynamics and adverse effects. Pharmacogenetics and Genomics.

                  West, H. J. (2017). Chemotherapy-induced hair loss (alopecia). Journal of the American Medical Association Oncology.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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