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Onivyde

Onivyde Side Effects

Julia Lee, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on October 9, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

Note: Side effects were reported from people taking [[EDITOR|DRUG_DISPLAY_NAME]] with oxaliplatin, 5-fluorouracil, and leucovorin (the NALIRIFOX regimen).

Onivyde serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Infection: fever, chills, body aches, headache, new cough, sore throat, feeling tired
  • Any diarrhea, but especially severe diarrhea: diarrhea that doesn’t go away, black or bloody stools, dehydration (dizziness, lightheadedness, faintness)
  • Lung problems: having trouble catching your breath, fever, new cough, worsening cough, wheezing
  • Serious allergic reaction: swelling of the face, lips, or tongue; trouble breathing; rash; itching
When do Onivyde possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Risk of diarrhea
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Onivyde side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Fatigue
  • Loss of appetite
  • Nausea
  • Pain, redness, or swelling with sores inside the mouth or throat
  • Vomiting
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