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MITOXANTRONE is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat acute nonlymphocytic leukemia (ANLL) and advanced prostate cancer. It is also used to treat certain types of multiple sclerosis. Compare topoisomerase inhibitors.

Potentially Unavailable: This drug has recently experienced shortages and may not be available at your pharmacy. Please call ahead to confirm availability. Learn More

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Mitoxantrone Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Your urine may turn blue-green for a few days after your dose. This is normal with this medicine.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Take a pregnancy test as directed before each dose of this medicine. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

There is a maximum amount of this medicine you should receive throughout your life. The amount depends on the medical condition being treated and your overall health. Your doctor will watch how much of this medicine you receive in your lifetime. Tell your doctor if you have taken this medicine before.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bladder pain

bloody or cloudy urine

cough or shortness of breath

difficult, burning, or painful urination

dizziness

fainting

fast, slow, or irregular heartbeat

frequent urge to urinate

lower back or side pain

pale skin

stomach pain

swelling or inflammation of the mouth

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Blood in the urine or stools

decrease in urination

fever or chills

pinpoint red spots on the skin

seizures

sore, red eyes

swelling of the feet and lower legs

yellow eyes or skin

Rare

Blue skin at the place of injection

pain or redness at the place of injection

skin rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Absent, missed, or irregular menstrual periods

back pain

body aches or pains

congestion

constipation

diarrhea

dryness or soreness of the throat

hair loss

headache

longer or heavier menstrual periods

nausea or vomiting

oral bleeding

pain or tenderness around the eyes and cheekbones

runny nose

sneezing

stopping of menstrual bleeding

stuffy nose

tender, swollen glands in the neck

thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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