Typical dosage for Mitoxantrone
Your provider will calculate the dose based on your body surface area (BSA, in units of m2), which takes into account your weight and height.
Dosing from manufacturer is listed below:
- Multiple sclerosis (MS): The typical dose is 12 mg/m2 given as a short infusion into the vein (intravenous, IV) every 3 months.
- Prostate cancer: The typical dose is 12 mg/m2 to 14 mg/m2 given as a short infusion into the vein every 3 weeks.
- Acute myeloid leukemia (AML): Your dose can differ depending on what stage of treatment you're in. The typical dose for induction is 12 mg/m2 given as an infusion into the vein once daily on days 1 to 3. Your provider will also give you other anticancer medications as part of treatment.
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Reviewed by:
Connie Zheng, PharmDConnie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

Reviewed by:
Sonja Jacobsen, PharmD, BCPS, BCOPSonja Jacobsen, PharmD, BCPS, BCOP, is a clinical oncology pharmacy specialist currently practicing in Seattle. She has been practicing as a pharmacist since 2015 and is licensed to practice in Washington state and North Carolina.