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Odefsey

Odefsey Side Effects

Hope Chang, PharmD, AAHIVPMichelle Nguyen, PharmD
Reviewed by Hope Chang, PharmD, AAHIVP, Michelle Nguyen, PharmD
Last reviewed on April 1, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (2%)
  • Sleep problems (2%)

Less Common Side Effects

  • Gas
  • Strange, abnormal dreams
  • Diarrhea
  • Nausea

Source: FDA

The following Odefsey side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • High lactic acid level—muscle pain or cramps, stomach pain, trouble breathing, general discomfort and fatigue
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Rash, fever, and swollen lymph nodes
  • Thoughts of suicide or self-harm, worsening mood, feelings of depression

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Dizziness
  • Headache
  • Nausea
  • Trouble sleeping
  • Vivid dreams or nightmares
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