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Novolin R

Used for Diabetes Type 2, Diabetes Type 1
Used for Diabetes Type 2, Diabetes Type 1

Novolin R is a type of insulin used to control blood sugar for many hours during the day, but it might take time to find the right dose that works for you. This medication is available over the counter without a prescription.

Last reviewed on December 12, 2021
basics-icon

What is Novolin R?

What is Novolin R used for?

  • Type 1 diabetes

  • Type 2 diabetes

How Novolin R works

Novolin R is a short-acting insulin. Insulin is a natural hormone your body normally makes to lower glucose (sugar) levels in the blood. It helps your body absorb and store sugar and fat from your bloodstream after eating a meal.

Are you looking for information on Novolin N (insulin NPH) or Novolin 70/30 (insulin NPH / insulin regular) instead?
When does Novolin R start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsNovolin R, Novolin R FlexPen, Novolin R FlexPen Relion, Novolin R Relion
Drug ClassInsulin
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription or over-the-counter

More on Novolin R essentials

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Avg retail price
$226.24(save 96.10%)
GoodRx discount
$8.82
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What are the side effects of Novolin R?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low blood sugar (hypoglycemia)
  • Injection site reactions (e.g., redness, warmth, changes in skin color)
  • Buildup or loss of fat tissue (lipodystrophy)
  • Weight gain
  • Swelling (edema)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe hypoglycemia (dangerously low blood sugar): if not treated, severe hypoglycemia can lead to unconsciousness, seizures, and even death
  • Severe allergic reactions: rash, hives, swelling of face, tongue, and throat, difficulty breathing
  • Dangerously low levels of potassium: if not treated, it can lead to difficulty breathing, irregular heartbeat, and even death
When do Novolin R possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Risk of low blood sugar
Risk of low potassium
Injection site reactions
Weight gain
Swelling (edema)
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Anxiety

blurred vision

chills

cold sweats

confusion

convulsions

cool, pale skin

cough

decreased urine

depression

difficulty with swallowing

dizziness

dry mouth

fast heartbeat

flushing or redness of the skin

headache

hives, itching, or rash

increased hunger

increased thirst

irregular heartbeat

loss of appetite

muscle pain or cramps

nausea

nightmares

numbness or tingling in the hands, feet, or lips

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

seizures

shakiness

slurred speech

sweating

swelling

tightness in the chest

unusual tiredness or weakness

unusually warm skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

redistribution or accumulation of body fat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Novolin R

thumbs-up

Pros

Available over the counter without a prescription

Can be used to treat type 1 or type 2 diabetes

Can be used if you have liver or kidney problems, unlike many other diabetes medications

Available in 2 dosage forms: insulin pen and vial

Pens are small enough to fit in your purse or pocket

thumbs-down

Cons

Must check your blood sugar regularly

Given through an injection

Can cause weight gain and fat buildup

Has higher risk of low blood sugar compared to some diabetes medications that are taken by mouth

Can cause low blood sugar (hypoglycemia), especially if you don't take it every day or have an inconsistent meal and exercise schedule

pharmacist-tips

Pharmacist tips for Novolin R

pharmacist
  • Check the vials or pens before use. They shouldn't contain any solid particles, and the solution should be clear and colorless.

    • Novolin R shouldn't be mixed with any types of insulin except for insulin NPH (Novolin N, Humulin N), which is an intermediate-acting insulin. If you're mixing Novolin R with inuslin NPH (Novolin N, Humulin N), make sure to draw up Novolin R into your syringe first. Inject yourself right after mixing.

      • If not in use or unopened, the Novolin R vials can be stored in a refrigerator until the expiration date, or at room temperature for 42 days. Opened vials should be stored at room temperature for up to 42 days. Don't refrigerate opened vials.

        • If not in use or unopened, the Novolin R pens can be stored in a refrigerator until the expiration date, or at room temperature for up to 28 days. Opened pens should be stored at room temperature for up to 28 days. Don't refrigerate opened pens.

          • Don't skip meals when taking Novolin R. Changes in meals, exercise routines, weight, stress, and illnesses can cause changes in your blood sugar. Tell your healthcare provider if you experience a change in your lifestyle because your dose might need to be adjusted.

            • For proper use, inject Novolin R under your skin (subcutaneously) in your upper arm, abdomen (stomach area), buttocks, or thigh (upper leg). Rotate injection sites to prevent skin irritation or fat buildup under the skin. Never inject it into a vein or muscle. This can cause dangerously low blood sugar levels and infections. Ask your pharmacist about proper injection technique.

              • Don't re-use needles. Always use a new needle for each injection. Reusing needles raises your chance of having blocked needles, which can cause you to get the wrong dose of Novolin R. Using a new needle for each injection also lowers your risk of getting an infection.

                • Teach yourself and your family members how to recognize and treat the symptoms of low blood sugar. The following are some common symptoms of low blood sugar: feeling shaky or hungry, being nervous or anxious, fast heartbeat, sweating or body chills, confusion, feeling sleepy, weakness, or low energy.

                  faqs

                  Frequently asked questions about Novolin R

                  How does Novolin R work in the body?
                  Novolin R releases a hormone called insulin into the body to lower blood sugar levels in the blood. It's a short-acting insulin that starts to work in about 30 minutes and lasts for several hours to control your blood sugar levels when you eat meals. Your healthcare provider might also prescribe you another type of insulin to provide you with more stable or long-term coverage that lasts throughout the day.
                  Can you take Novolin R and metformin together?
                  Novolin R can be taken with other oral diabetes medications, like metformin, if your blood sugar levels are still high. Talk to your provider about your diabetes treatment and what medications might be right for you.
                  Can you take Novolin R without food?
                  Taking Novolin R without eating will put you at higher risk of low blood sugar (hypoglycemia), which can sometimes be life-threatening. Symptoms of low blood sugar include feeling shaky or hungry, being nervous or anxious, fast heartbeat, sweating or body chills, confusion, feeling sleepy, weakness, or low energy. Make sure you know how to treat low blood sugar before you start this medication. You should carry some form of sugar with you at all times while you are taking this medication because you can use these to raise your blood sugar if it becomes too low. Some examples of fast-acting sugars include: 3-4 glucose (sugar) tablets, 6-8 pieces of hard candy, or one-half cup of fruit juice.
                  Do I need to prime the Novolin R pen?
                  Yes, make sure to prime the Novolin R pen before each injection because air can collect in the cartridge. To do this, you will turn your pen until the display reads 2 units. You will hold the pen with the needle facing up and tap it to make sure any air bubbles move to the top of the pen towards the needle. Remove the needle cover, then press the button all the way down. You should see a small amount of insulin come out of the pen. This makes sure you are getting the proper dosage of insulin and that your needle is not blocked.
                  What's the difference between Novolin R and Humulin R?
                  Novolin R and Humulin R are both forms of regular insulin, a short-acting form of insulin that starts to work in about 30 minutes and lasts for several hours in the body. They're both brand-name medications only, and are available without a prescription from your provider. Humulin R is unique in that it also comes in a more concentrated form, called Humulin R U-500. This concentrated version of Humulin R is available by prescription only, and is only meant for people who require a lot of units of insulin per day.
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                  warings-icon

                  What are the risks and warnings for Novolin R?

                  Novolin R can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Infections or diseases

                  Never share Novolin R pens, syringes, or needles with anyone else. Sharing Novolin R with someone puts you at risk of getting very dangerous diseases and infections.

                  risk-warning

                  Low blood sugar (hypoglycemia)

                  • Risk factors: Changes in diet and exercise | Drinking alcohol | Taking other medications for diabetes | Over age 65 | Liver or kidney problems | Not injecting insulin correctly

                    Novolin R alone or together with other diabetic medications can cause low blood sugar. Very low blood sugar may be life-threatening. Symptoms of low blood sugar include feeling shaky, being nervous or anxious, fast heartbeat, sweating or body chills, confusion, feeling sleepy, weakness or low energy, and excessive hunger. This can happen suddenly and can appear differently for each person. Make sure you know how to treat low blood sugar before using this medication. It's best to carry with you some form of fast-acting sugar at all times while you are taking this medication because you can use these to raise your blood sugar if it becomes too low. Some examples of fast-acting sugars include: 3-4 glucose (sugar) tablets, 6-8 pieces of hard candy, or one-half cup of fruit juice.

                    risk-warning

                    Low blood potassium levels

                    • Risk factors: Taking laxatives | Taking medications that increase urination

                      Novolin R can lower levels of potassium in your blood which can be dangerous. You're more at risk if you're already taking medications that lower your potassium. Your provider will check your potassium levels regularly and might give you medications to keep your potassium normal. Symptoms of low potassium levels include weakness, muscle cramps or twitches, digestive problems, abnormal heartbeats, or kidney problems.

                      risk-warning

                      Swelling and heart failure

                      • Risk factors: Taking PPAR-gamma agonists | Heart failure

                        Taking Novolin R with thiazolidinediones (like pioglitazone or rosiglitazone), which are called PPAR-gamma agonists, can cause your body to hold onto fluid. This can be especially dangerous if you have heart failure because additional fluid can worsen your heart failure. Make sure your provider knows about your complete medical history before starting this medication.

                        dosage

                        Novolin R dosage forms

                        The average cost for 1 carton of 5 flexpens of 3ml of 100 units/ml of Novolin R is $96.24 with a free GoodRx coupon. This is 57.46% off the average retail price of $226.24.
                        carton
                        Carton
                        DosageQuantityPrice as low asPrice per unit
                        ReliOn of 5 flexpens of 3ml1 carton$42.88$42.88
                        5 flexpens of 3ml of 100 units/ml1 carton$96.24$96.24
                        flexpen
                        Flexpen
                        DosageQuantityPrice as low asPrice per unit
                        3ml of 100 units/ml1 flexpen$8.82$8.82
                        vial
                        Vial
                        DosageQuantityPrice as low asPrice per unit
                        10ml of 100 units/ml1 vial$56.94$56.94
                        ReliOn of 100 units/ml1 vial$24.88$24.88

                        Typical dosing for Novolin R

                        The dose of Novolin R will be different for each person. The dose depends on whether you're using it for type 1 diabetes or type 2 diabetes, your weight, how well you respond to insulin, and your blood sugar levels. Please follow the directions from your provider carefully.

                        Novolin R is typically injected underneath the skin (subcutaneously) before each meal.

                        interactions

                        Interactions between Novolin R and other drugs

                        Novolin R may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Novolin R. Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                        How much does Novolin R cost?

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                        contraindications-icon

                        Novolin R contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Novolin R will not be safe for you to take.
                        • Having episodes of low blood sugar (hypoglycemia)

                        alternatives

                        What are alternatives to Novolin R?

                        There are a number of medications that your doctor can prescribe in place of Novolin R. Compare a few possible alternatives below.
                        Novolin R
                        Used for:
                        • Type 1 diabetes

                        • Type 2 diabetes

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                        latest news

                        What is the latest news about Novolin R?

                        images

                        Novolin R images

                        colorless - Novolin R 100unit / mL Solution for Injection
                        This medicine is Colorless Vial.colorless - Novolin R 100unit / mL Solution for Injection

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