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Naproxen ER Coupon - Naproxen ER 500mg tablet

naproxen sodium ER

Generic Naprelan
Used for Rheumatoid Arthritis, Osteoarthritis, Gout, Pain, Menstrual Pain
Used for Rheumatoid Arthritis, Osteoarthritis, Gout, Pain, Menstrual Pain

Prescription-strength naproxen sodium ER (Naprelan) is a non-steroidal anti-inflammatory drug (NSAID). It relieves pain and inflammation in adults by blocking specific proteins called cyclooxygenases. Naproxen sodium ER (Naprelan) can help with certain conditions, such as rheumatoid arthritis, osteoarthritis, or gout. This medication is available as an extended-release (ER) tablet that's taken by mouth mostly once per day. Some side effects include headache, indigestion, and flu-like symptoms.

Last reviewed on May 13, 2024
basics-icon

What is Naproxen sodium ER (Naprelan)?

What is Naproxen sodium ER (Naprelan) used for?

How Naproxen sodium ER (Naprelan) works

Naproxen sodium ER (Naprelan) is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking proteins (called cyclooxygenase, or COX) in your body that cause inflammation, pain, and swelling.

Are you looking for information on over-the-counter naproxen (Aleve) or naproxen (Naprosyn) instead?
When does Naproxen sodium ER (Naprelan) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsNaprelan
Drug ClassNSAID
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Naproxen sodium ER (Naprelan) essentials

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$1062.30(save 92.98%)
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What are the side effects of Naproxen sodium ER (Naprelan)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (15%)
  • Indigestion (14%)
  • Cold or flu-like symptoms (up to 10%)
  • Heartburn (up to 9%)
  • General pain and stomach pain (up to 9%)
  • Constipation or diarrhea (up to 9%)
  • Nausea (up to 9%)
  • Drowsiness (up to 9%)
  • Itchy skin (up to 9%)
  • Bruising (up to 9%)
  • Ringing in the ears (up to 9%)
  • Swelling (up to 9%)
  • Shortness of breath (up to 9%)

Other Side Effects

  • Passing gas
  • Vomiting
  • Trouble swallowing
  • Mouth sores
  • Dizziness
  • Leg cramps
  • Muscle or joint pain
  • Changes in hearing or vision
  • Feeling more thirsty

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
  • Stroke: chest pain, trouble breathing, weakness in one part of your body or face, slurred speech
  • Heart failure: difficulty breathing, swelling, fast heartbeat
  • Dangerously high blood pressure: headache, shortness of breath, changes in vision, light-headedness, fatigue
  • Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
  • Kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
  • Allergic reactions: hives, rash, blisters, swelling of the lips or tongue, difficulty breathing
  • Serious skin reaction: skin reddening, blisters, rash
When do Naproxen sodium ER (Naprelan) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Stomach pain
Heartburn
Nausea
Risk of stomach ulcers / bleeding
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Heart attackpain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
  • Increase in blood pressure
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Round red or dark patches on the skin that may itch, burn, and blister
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Naproxen sodium ER (Naprelan)

thumbs-up

Pros

Taken by mouth

Effect lasts longer than some other NSAIDs, such as ibuprofen (Advil)

Long-acting version of naproxen; typically taken once daily

thumbs-down

Cons

Cannot crush or split naproxen sodium ER (Naprelan) tablets

Can't be taken by children

Can't take during pregnancy

pharmacist-tips

Pharmacist tips for Naproxen sodium ER (Naprelan)

pharmacist
  • The naproxen sodium ER (Naprelan) tablets have a special coating on them, so you'll need to swallow them whole. Don't break, crush, or chew the tablets. Doing so will damage the special coating and affect how naproxen sodium ER (Naprelan) is absorbed by your body. If you're having trouble swallowing the tablets, let your prescriber know. They might consider switching you naproxen (Naprosyn) suspension.

    • Naproxen sodium ER (Naprelan) raises the risk of stomach bleeding. Tell your prescriber right away if you experience unexplained vomiting or stomach pain, or blood in your vomit or stool. They can let you know if you need more medical attention.

      • It's best to avoid drinking alcohol while taking naproxen sodium ER (Naprelan). Doing so can raise your risk for stomach bleeding and other stomach-related side effects. If you drink alcohol regularly and it's difficult for you to stop, talk with your healthcare team. They can recommend resources to help you stop drinking, or they can discuss other alternative options to help with your condition.

        • Never take naproxen sodium ER (Naprelan) with other NSAIDs, such as ibuprofen (Motrin, Advil). Doing so puts you at higher risk for stomach bleeds, stroke, and heart attack. Make sure to carefully check the manufacturer's label for over-the-counter pain and cold medications because they might contain NSAIDs. Ask a healthcare professional if you're not sure whether you're already taking a medication with an NSAID.

          • If you're pregnant, talk to your healthcare team about safer alternatives than naproxen sodium ER (Naprelan) for pain. You should avoid taking naproxen sodium ER (Naprelan) during the second half of pregnancy because it might cause problems to your unborn baby or cause complications during delivery. And the safety of naproxen sodium ER (Naprelan) in the first half of pregnancy isn't clear.

            • If you're breastfeeding, discuss with your healthcare team about the risks and benefits of taking naproxen sodium ER (Naprelan). Limited research shows that naproxen sodium ER (Naprelan) can get into breastmilk. This means there might be a small risk of harm to the breastfed baby.

              faqs

              Frequently asked questions about Naproxen sodium ER (Naprelan)

              How long does naproxen sodium ER (Naprelan) take to kick in?
              If you're taking naproxen sodium ER (Naprelan) for pain, you might feel your pain starting to improve 30 to 60 minutes after a dose. And it can take about 4 hours to feel the full effects of this medication. If you're taking naproxen sodium ER (Naprelan) for inflammatory conditions, like rheumatoid arthritis or osteoarthritis, you might start to feel better after a week. And it can take about 2 weeks to notice the full benefits of this medication. Talk to your prescriber if you're concerned with how well naproxen sodium ER (Naprelan) is working for you.
              Does naproxen sodium ER (Naprelan) help with headaches?
              You should only take naproxen sodium ER (Naprelan) for headaches if prescribed by your HCP. While naproxen sodium ER (Naprelan) can help with headaches, it might not be appropriate for you depending on what's causing your headache and what other health conditions you have. For example, if you have migraines fairly often, your HCP might caution against taking naproxen sodium ER (Naprelan) for pain relief each time because doing so might lead to rebound headaches. In this case, your HCP might ask you to consider a medication to prevent migraines instead. Talk with your healthcare team if you have more questions on naproxen sodium ER (Naprelan) and headache.
              Is naproxen sodium ER (Naprelan) over the counter?
              No, naproxen sodium ER (Naprelan) isn't available over-the-counter; it's prescription-strength naproxen. But there's an over-the-counter (OTC) form, naproxen (Aleve), that's commonly found in most retail pharmacies.
              Does naproxen sodium ER (Naprelan) make you sleepy?
              Yes, some people do experience sleepiness after starting naproxen sodium ER (Naprelan). When you're taking this medication for the first time, pay attention to how it's making you feel. If you feel too sleepy to go about your day, contact your prescriber. They can check to see if the sleepiness is caused by naproxen sodium ER (Naprelan) or other factors. If needed, they can recommend an alternative medication to help with your symptoms.
              Does naproxen sodium ER (Naprelan) cause constipation?
              Yes, constipation is one of the more common side effects of naproxen sodium ER (Naprelan). You can lower your risk of constipation by adding fiber-rich foods (e.g., broccoli, spinach, whole grains) to your diet. You can also do so by drinking enough water or additive-free beverages to stay hydrated. If you still have constipation after making these or other lifestyle changes, talk with your pharmacist or primary care provider. They might be able to recommend appropriate over-the-counter options for treating constipation, such as docusate (Colace) or polyethylene glycol (Miralax).
              Does naproxen sodium ER (Naprelan) raise blood pressure?
              Yes, it's possible for naproxen sodium ER (Naprelan) to potentially raise your blood pressure. This medication might not be the best choice if you already have high blood pressure or if you're taking blood pressure medications. If your healthcare provider decides to prescribe naproxen sodium ER (Naprelan), they might ask you to check your blood pressure regularly at home to see how the medication might be affecting your blood pressure. It's best to write down your blood pressure numbers in a journal and bring it to your appointments with your cardiologist or primary care provider. Let them know if you notice any changes in your blood pressure after starting this medication.
              Can you take acetaminophen (Tylenol) with naproxen sodium ER (Naprelan)?
              Acetaminophen (Tylenol) doesn't have any known interactions with naproxen sodium ER (Naprelan). Sometimes, HCPs might prescribe both medications together for people who need additional pain relief. But acetaminophen (Tylenol) might not be a good add-on option for everyone because this medication can raise the risk for liver damage. Check with your healthcare team to see if you can take acetaminophen (Tylenol) with naproxen sodium ER (Naprelan).
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              What are the risks and warnings for Naproxen sodium ER (Naprelan)?

              Naproxen sodium ER (Naprelan) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Stomach bleeding

              • Risk factors: Older adult | History of stomach bleeding or bleeding problems | Liver problems | Taking other medications that raise your risk of bleeds | Drinking alcohol | Smoking | Taking naproxen sodium ER (Naprelan) for a long time

                Naproxen sodium ER (Naprelan), like all NSAIDS, raises your risk for stomach ulcers (sores) and bleeds. Stomach bleeding can happen at anytime during treatment; it's a dangerous side effect that requires treatment right away. Often times, people who have stomach bleeds don't experience any symptoms. Make sure to tell your healthcare professional (HCP) or pharmacist about all of your conditions and medications before starting naproxen sodium ER (Naprelan) so they can talk with you about your risk for stomach bleeding. If you're feeling faint, vomiting blood, have bloody or dark stools, or have severe stomach pain or discomfort that doesn't go away while taking naproxen sodium ER (Naprelan), seek medical attention right away.

                risk-warning

                Heart attack and stroke

                • Risk factors: Heart problems | Taking higher doses of naproxen sodium ER (Naprelan) | Taking naproxen sodium ER (Naprelan) for a long time | Past or planned heart surgery

                  Naproxen sodium ER (Naprelan) might raise your risk of having blood clots, which can cause a heart attack or stroke. To lower your risk of blood clots and heart problems, your HCP will prescribe naproxen sodium ER (Naprelan) for the shortest time needed to treat your condition. If you have heart problems, talk to your HCP before starting this medication. Don't take naproxen sodium ER (Naprelan) if you had, or will have, heart surgery. Call 911 or get immediate help if you experience chest pain, shortness of breath, weakness on one side of your body, or trouble speaking or walking.

                  risk-warning

                  High blood pressure and heart failure

                  • Risk factors: Heart problems

                    Naproxen sodium ER (Naprelan) can cause your body to hold onto extra fluid, which can raise your blood pressure or put you at risk for heart failure. Tell your HCP if you have a history of heart problems, or are taking blood pressure medications, before starting naproxen sodium ER (Naprelan) to make sure it's safe for you. Your HCP will screen you for heart problems before starting you on this medication. Some forms of naproxen sodium ER (Naprelan) contains sodium, so it's important to keep track of how much you're getting from your doses if you're on a low-salt diet. If you experience unexplained fainting, chest pain with physical activity, or irregular heartbeat while taking naproxen sodium ER (Naprelan), contact your HCP.

                    risk-warning

                    Kidney damage

                    • Risk factors: Older adult | Kidney problems | Heart failure | Liver problems | High blood sugar levels | Not enough fluids in the body (dehydration) | Taking other medications that can cause kidney problems

                      Naproxen sodium ER (Naprelan) can cause kidney problems. Your risk is higher if you have certain factors like older age, certain medical problems like diabetes, or you're taking medications that can cause kidney problems. Your healthcare professional might order lab tests to monitor your kidney health before and during treatment with naproxen sodium ER (Naprelan). If your kidney health worsens, your HCP might stop your naproxen sodium ER (Naprelan) treatment. Contact your HCP if you develop any signs or symptoms of kidney failure, including changes in your need to urinate, tiredness, dry and itchy skin, low appetite, and muscle cramps.

                      risk-warning

                      Liver problems

                      • Risk factors: History of liver problems

                        Though rare, naproxen sodium ER (Naprelan) can cause serious liver problems that can lead to liver failure. Get medical attention right away if you notice swelling of your stomach, stomach pain, yellowing of your skin or the whites of your eyes, stool changes (black, tarry, or bloody stools), nausea, vomiting, confusion, or dark or brown urine. You might need to stop using the medication to prevent further liver damage.

                        risk-warning

                        Severe allergic reactions

                        • Risk factors: Aspirin allergy | Aspirin-sensitive asthma | Nasal polyps | NSAID allergy

                          Severe allergic reactions to naproxen sodium ER (Naprelan) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis. Let your HCP know if you have an allergy to aspirin or other NSAIDs before starting naproxen sodium ER (Naprelan). If you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after using naproxen sodium ER (Naprelan), get medical attention right away.

                          Although rare, naproxen sodium ER (Naprelan) can cause serious skin reactions called Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reaction with eosinophilia and systemic symptoms (DRESS). If you notice changes in your skin, such as rash, blisters, skin reddening, or skin peeling, stop using naproxen sodium ER (Naprelan) and get medical attention right away.

                          risk-warning

                          Not for use in pregnant or breastfeeding females

                          Naproxen sodium ER (Naprelan) can cause harm to your unborn baby, especially if it's taken in the second half of pregnancy (after week 20). It can cause serious complications, such as heart or kidney problems in your unborn baby or problems during delivery. Speak to your HCP about the risks and benefits of taking naproxen sodium ER (Naprelan) if you're pregnant before taking this medication. Ask whether there are safer alternatives.

                          More on Naproxen sodium ER (Naprelan) warnings

                          dosage

                          Naproxen sodium ER (Naprelan) dosage forms

                          The average cost for 20 tablets of 500mg of Naproxen sodium ER (Naprelan) is $101.80 with a free GoodRx coupon. This is 90.42% off the average retail price of $1062.30.
                          tablet
                          Tablet
                          DosageQuantityPrice as low asPrice per unit
                          375mg20 tablets$74.56$3.73
                          500mg20 tablets$101.80$5.09
                          750mg30 tablets$128.44$4.28

                          Typical dosing for Naproxen sodium ER (Naprelan)

                          The different strengths and formulations of naproxen aren't interchangeable. Your healthcare team will likely need to adjust your dose if they're switching you from one form of naproxen to another.

                          • RA, OA, and AS: The typical dose is 750 mg by mouth once per day, or 500 mg by mouth twice per day. The maximum daily dose is 1,500 mg but only for a short period of time.

                          • Pain, menstrual cramps, tendonitis, and bursitis: The typical dose 1,000 mg by mouth once daily. If more pain relief is needed, the dose can be raised to 1,500 mg by mouth once daily for a short amount of time.

                          • Gout: The typical dose is 1,000 mg to 1,500 mg by mouth on the first day of a gout attack, then 1,000 mg by mouth once daily until your symptoms go away.

                          More on Naproxen sodium ER (Naprelan) dosage forms

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                          How much does Naproxen sodium ER (Naprelan) cost?

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                          contraindications-icon

                          Naproxen sodium ER (Naprelan) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Naproxen sodium ER (Naprelan) will not be safe for you to take.
                          alternatives

                          What are alternatives to Naproxen sodium ER (Naprelan)?

                          There are a number of medications that your doctor can prescribe in place of Naproxen sodium ER (Naprelan). Compare a few possible alternatives below.
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                          • Osteoarthritis

                          • Rheumatoid arthritis

                          • Juvenile rheumatoid arthritis

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                          Naproxen sodium ER (Naprelan) images

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                          References

                          Best studies we found

                          Almatica Pharma Inc. (2024). Naprelan- naproxen sodium tablet, film coated, extended release [package insert]. DailyMed.

                          Drugs and Lactation Database (LactMed®). (2024). Naproxen. National Institute of Child Health and Human Development.

                          National Heart, Lung, and Blood Institute. (2022). What is coronary artery bypass grafting?

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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