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Acetaminophen/Guaifenesin/Phenylephrine

Acetaminophen/Guaifenesin/Phenylephrine Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on January 9, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

  • Nervousness
  • Trouble sleeping

Acetaminophen/Guaifenesin/Phenylephrine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions: rash; hives; difficulty breathing; swelling of face, lips, tongue, or throat
  • Serious skin reaction: skin reddening, blisters, rash
  • Liver damage: severe stomach pain, yellowing of skin or eyes, nausea, vomiting, loss of appetite

Source: DailyMed

The following Acetaminophen/Guaifenesin/Phenylephrine side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart palpitations—rapid, pounding, or irregular heartbeat
  • Increase in blood pressure
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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