Acetaminophen/Guaifenesin/Phenylephrine Dosage

There are several manufacturers of this medication with different strengths of each ingredient, different dosage forms (e.g., tablet, solution), and different age cut-offs. The dose might differ slightly depending on which manufacturer of the medication you have.

Be sure to check the medication box carefully for specific directions. Ask your pharmacist if you have any questions about your product.

Below are a few examples of product names with their dosing instructions.

Caplets

Tylenol Sinus Severe and its generic: Each caplet contains 325 mg of acetaminophen, 200 mg of guaifenesin, and 5 mg of phenylephrine.

• Adults and children age 12 years and older: The typical dose is 2 caplets by mouth every 4 hours. Don't take more than 10 caplets in a 24-hour period.
• Children younger than 12 years old: Ask your child's provider.

Mucinex Sinus-Max Severe Congestion and Pain: Each caplet contains 325 mg of acetaminophen, 200 mg of guaifenesin, and 5 mg of phenylephrine.

• Adults and children age 12 years and older: The typical dose is 2 caplets by mouth every 4 hours. Don't take more than 12 caplets in a 24-hour period.
• Children younger than 12 years old: Ask your child's provider.

Oral solution

Mucinex Sinus-Max Severe Congestion and Pain: Each 20 mL contains 650 mg of acetaminophen, 400 mg of guaifenesin, and 10 mg of phenylephrine.

• Adults and children age 12 years or older: The typical dose is 20 mL by mouth every 4 hours while you're having symptoms. Don't use more than 6 doses in a 24-hour period.
• Children younger than 12 years old: Ask your child's provider.