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Motpoly XR Coupon - Motpoly XR 200mg capsule

Motpoly XR

lacosamide ER
Used for Epilepsy
Used for Epilepsy

Motpoly XR (lacosamide) is used to treat partial-onset seizures (also known as focal onset aware seizures). This medication can be used in adults and children weighing at least 110 lbs. It's an extended-release capsule that you take by mouth once per day. Some common side effects include dizziness, nausea, and headaches. Motpoly XR (lacosamide) is currently available as a brand-name medication only.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on June 30, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesImagesReferencesPricesMedicare
Motpoly XR (lacosamide) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Motpoly XR (lacosamide)?

What is Motpoly XR (lacosamide) used for?

  • Partial-onset seizures in adults and children weighing at least 110 lbs

How Motpoly XR (lacosamide) works

Motpoly XR (lacosamide) is an antiepileptic (another name for anti-seizure medication). While it's not exactly clear how the medication works to treat seizures, it's thought to slow the activity of certain sodium channels in the brain. This helps to calm your brain activity to control seizures.

Are you looking for information on Vimpat (lacosamide immediate-release) instead?

Drug Facts

Common BrandsMotpoly XR
Drug ClassAntiepileptic
Controlled Substance ClassificationSchedule V
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$1541.25(save 29.02%)
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What are the risks and warnings for Motpoly XR (lacosamide)?

Motpoly XR (lacosamide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Suicidal thoughts or behavior

  • Risk factors: Taking other anti-seizure medications

    Motpoly XR (lacosamide) raises your risk of having thoughts of suicide or harming yourself. This risk can appear as early as 1 week after you start taking Motpoly XR (lacosamide) and can continue throughout treatment. If you or anyone around you notices that you have suicidal thoughts or unusual behavior (e.g., anxiety, panic attacks, difficulty sleeping, feeling angry or irritated, restlessness) while taking Motpoly XR (lacosamide), get medical help right away.

    risk-warning

    Difficulty with speech, concentration, and movement

    • Risk factors: Taking high doses of Motpoly XR (lacosamide) | Drinking alcohol | Taking other medications that can cause sleepiness or dizziness

      Because Motpoly XR (lacosamide) works in the brain, it's possible to have side effects like difficulty concentrating, speech or language problems, and problems with coordination and balance. Motpoly XR (lacosamide) can also cause dizziness and sleepiness, which can lower your ability to think, react, and focus. Your risk for these side effects might be higher if you're taking other medications that can make you sleepy or dizzy (e.g., benzodiazepines, muscle relaxants, sleep medications). Make sure you know how Motpoly XR (lacosamide) affects you before driving a car or doing activities that require your concentration. Talk to your healthcare provider right away if these side effects affect your daily life while you're taking Motpoly XR (lacosamide).

      risk-warning

      Heart rhythm problems

      • Risk factors: History of heart rate or heart rhythm problems | Heart problems | Taking other medications that affect the heart

        Rare cases of heart rhythm problems have been reported in people who took Motpoly XR (lacosamide). Examples of these problems include atrial fibrillation and atrial flutter. Let your provider know if you have a history of an irregular heartbeat before starting Motpoly XR (lacosamide). If you experience chest pain, dizziness, weakness, or shortness of breath while taking Motpoly XR (lacosamide), contact your provider.

        risk-warning

        Severe allergic and skin reactions

        Although rare, Motpoly XR (lacosamide) can cause a serious reaction called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), which can sometimes be life-threatening. This reaction can include changes in your skin (e.g., rash, blisters, skin reddening or peeling, swollen lymph nodes), a fever, dark urine, swelling in your face, or trouble breathing. If you experience any of these symptoms at any time while taking Motpoly XR (lacosamide), stop using the medication and get medical attention right away.

        risk-warning

        Withdrawal seizures after stopping Motpoly XR (lacosamide) suddenly

        Antiepileptic (anti-seizure) medications like Motpoly XR (lacosamide) shouldn't be stopped suddenly because it can cause your seizures to come back. Don't stop taking Motpoly XR (lacosamide) without talking to your provider first. They'll instruct you on how to lower your dose slowly over time until you can completely stop taking it.

        basics-icon

        What are the side effects of Motpoly XR (lacosamide)?

        The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

        Common Side Effects

        • Dizziness (up to 30%)
        • Headache (up to 14%)
        • Nausea (up to 11%)
        • Double vision (up to 10%)
        • Blurred vision (up to 9%)
        • Vomiting (up to 9%)
        • Sleepiness (up to 8%)
        • Fatigue or tiredness (up to 7%)
        • Difficulty with movement or coordination (up to 7%)

        Other Side Effects

        • Diarrhea
        • Shaking
        • Memory problems
        • Depression
        • Spinning sensation
        • Itching
        Note: Side effects were reported by people who took Vimpat (lacosamide immediate-release) with other anti-seizure medications during clinical studies. The side effects you experience with Motpoly XR (lacosamide), with or without other anti-seizure medications, might be different.

        Serious Side Effects

        Contact your healthcare provider immediately if you experience any of the following.
        • Suicidal thoughts or behaviors
        • Abnormal heart rhythm: chest pounding, irregular heartbeat, chest pain, trouble breathing, feeling faint or lightheaded
        • Serious allergic and skin reactions: hives, rash, blisters, skin reddening, fever, swelling of the lips or tongue, difficulty breathing

        Source: DailyMed

        The following side effects have also been reported

        Side effects that you should report to your care team as soon as possible:

        • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
        • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
        • Rash, fever, and swollen lymph nodes
        • Thoughts of suicide or self-harm, worsening mood, feelings of depression

        Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

        • Dizziness
        • Double vision
        • Drowsiness
        • Headache
        • Loss of balance or coordination
        • Nausea
        pros-and-cons

        Pros and cons of Motpoly XR (lacosamide)

        thumbs-up

        Pros

        Works well to treat partial-onset seizures

        Taken by mouth once per day

        Can take with or without food

        thumbs-down

        Cons

        Is a controlled substance because of its risk of misuse and dependence

        Must swallow the capsule whole

        Can't be used in children weighing less than 110 lbs

        pharmacist-tips

        Pharmacist tips for Motpoly XR (lacosamide)

        pharmacist

        • You can take Motpoly XR (lacosamide) with or without food. But if it upsets your stomach, try taking the medication with food to help. Make sure to swallow the capsule whole with some liquid.

          • Most side effects from Motpoly XR (lacosamide) typically get better or go away after you've been taking it for a few weeks. They're more likely to happen with higher doses of this medication. These side effects might return if your dose changes.

            • Motpoly XR (lacosamide) can raise the risk of suicidal thoughts. Contact your provider right away if you or your loved ones notice any new or worsening changes in your behavior or mood while taking the medication.

              • Motpoly XR (lacosamide) commonly causes sleepiness, tiredness, and dizziness. Don't drive or do anything requiring concentration until you know how this medication affects you. Also, avoid drinking alcohol because it can worsen these effects. These side effects can also be worse if you're also taking medications like phenobarbital, opioid pain medications, or antihistamines.

                • Motpoly XR (lacosamide) can interact with many medications, including medications that are used for heart rhythm problems (antiarrhythmics). Make sure to tell your provider and pharmacist about all of the medications you're taking or planning to take before starting Motpoly XR (lacosamide).

                  • Don't change your dose or stop taking Motpoly XR (lacosamide) suddenly without talking to your provider first. Doing so can cause your seizures to come back. If you want to take a lower dose or stop the medication, follow your provider's instructions to do so safely and slowly over a period of time.

                    faqs

                    Frequently asked questions about Motpoly XR (lacosamide)

                    How does Motpoly XR (lacosamide) and Vimpat (lacosamide) differ?
                    Both Motpoly XR and Vimpat are brand names that contain lacosamide as the active ingredient. Both brand names are FDA approved to treat partial-onset seizures, but Vimpat is also approved to treat primary generalized tonic-clonic seizures. Vimpat is an immediate-release version of lacosamide that you need to take twice per day. On the other hand, Motpoly XR is an extended-release version of lacosamide that lasts throughout the day and is only taken once per day. Additionally, Motpoly XR (lacosamide) is only available as a brand-name tablet, while Vimpat is available as a lower-cost, generic tablet, oral liquid, and injection. Discuss with your provider whether Vimpat or Motpoly XR best fits your needs.
                    Is Motpoly XR (lacosamide) a controlled substance?
                    Yes, Motpoly XR (lacosamide) is a schedule V controlled substance. This is because it has risks of misuse and dependence. Misuse is when a medication is used for non-medical reasons for its desirable physical or emotional effects (e.g., a "high" feeling). Dependence is when you rely on a medication to function normally and experience withdrawal symptoms if you suddenly stop taking it. Withdrawal symptoms haven't been observed in people who stop taking Motpoly XR (lacosamide) suddenly, but the risk can't be ruled out. To help lower the risks for misuse and dependence, only take Motpoly XR (lacosamide) as prescribed by your provider. Follow your provider's instructions to slowly lower the dose before completely stopping the medication.
                    How fast can I come off of Motpoly XR (lacosamide)?
                    It takes at least a week to completely come off Motpoly XR (lacosamide). However, how fast you can stop taking the medication will probably depend on your dose, how severe your seizures are, and whether you're experiencing severe side effects. Just like many antiepileptics, suddenly stopping Motpoly XR (lacosamide) raises your risk for having seizures again. If you feel Motpoly XR (lacosamide) isn't right for you and would like to stop taking it, your provider can help you come up with a plan to slowly lower the dose over time. Don't stop taking Motpoly XR (lacosamide) without first talking with your provider.
                    Is Motpoly XR (lacosamide) safe during pregnancy?
                    It's not completely clear how safe Motpoly XR (lacosamide) is during pregnancy because it hasn't been well-studied. Results from a global safety database suggest that there might be a low risk of harm to unborn babies when Motpoly XR (lacosamide) is used during pregnancy. However, the medication caused some harm to babies in animal studies. Make sure to let your provider know if you're pregnant or thinking of becoming pregnant before starting Motpoly XR (lacosamide) or during treatment. If you're currently pregnant and taking Motpoly XR (lacosamide), it's encouraged that you enroll in the North American Antiepileptic Drug (NAAED) pregnancy registry to help researchers learn more about the risks. This registry monitors the safety of anti-seizure medications during pregnancy.
                    Can I take Motpoly XR (lacosamide) if I'm breastfeeding?
                    Ask your provider if you can breastfeed while taking Motpoly XR (lacosamide). This medication is found in low amounts in breast milk, but research suggest it's not likely to cause harm in breastfed babies. If your provider says it's okay for you to breastfeed while taking Motpoly XR (lacosamide), watch your baby for sleepiness, weight gain, or development milestone issues. Contact your baby's provider if you notice any of these problems.
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                    dosage

                    Motpoly XR (lacosamide) dosage forms

                    The average cost for 60 capsules of 200mg of Motpoly XR (lacosamide) is $1093.99 with a free GoodRx coupon. This is 29.02% off the average retail price of $1541.25.
                    capsule
                    Capsule
                    DosageQuantityPrice as low asPrice per unit
                    100mg60 capsules$1093.99$18.23
                    150mg60 capsules$1093.99$18.23
                    200mg60 capsules$1093.99$18.23

                    Typical dosing for Motpoly XR (lacosamide)

                    The typical starting dose is 100 mg or 200 mg by mouth once per day. The typical maintenance dose is 200 mg to 400 mg by mouth once per day. The maintenance dose helps control your seizures over a long period of time.

                    Your dose is based on several factors, such as your age and whether you're taking Motpoly XR (lacosamide) alone or with other anti-seizure medications. It might also differ if you have kidney or liver problems.

                    Your provider will adjust your dose based on whether you're taking another medication that interacts with Motpoly XR (lacosamide), how well Motpoly XR (lacosamide) is working to control your seizures, and whether you're having side effects.

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                    How much does Motpoly XR (lacosamide) cost?

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                    Motpoly XR (brand)
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                    alternatives

                    What are alternatives to Motpoly XR (lacosamide)?

                    There are a number of medications that your doctor can prescribe in place of Motpoly XR (lacosamide). Compare a few possible alternatives below.
                    Motpoly XR (lacosamide)
                    Used for:

                    • Partial-onset seizures in adults and children weighing at least 110 lbs

                    $1093.99 Lowest GoodRx priceView Prices
                    Levetiracetam (Keppra)
                    Used for:
                    $9.00 Lowest GoodRx priceView Prices
                    Lamotrigine (Lamictal)
                    Used for:

                    • Seizures (partial seizures, tonic-clonic seizures)

                    • Seizures of Lennox-Gastaut syndrome - immediate-release only

                    • Bipolar disorder - immediate-release only

                    $9.00 Lowest GoodRx priceView Prices
                    images

                    Motpoly XR (lacosamide) images

                    Blue And White A 200 - Motpoly XR 200mg Extended-Release Capsule
                    This medicine is Blue And White Capsule Imprinted With "A 200".Blue And White A 200 - Motpoly XR 200mg Extended-Release Capsule

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                    References

                    Best studies we found

                    American Heart Association. (2022). What is an arrhythmia?

                    Aucta Pharmaceuticals, Inc. (2023). Motpoly XR- lacosamide capsule, extended release [package insert]. DailyMed.

                    Ben-Menachem, E., et al. (2021). Long‐term safety and tolerability of lacosamide monotherapy in patients with epilepsy: Results from a multicenter, open‐label trial. Epilepsia Open.

                    View All References (5)

                    Drugs and Lactation Database (LactMed). (2022). Lacosamide. National Institute of Child Health and Human Development.

                    Golembesky, A., et al. (2017). Outcomes following exposure to the antiepileptic drug lacosamide during pregnancy – Results from a global safety database (P5.231). Neurology.

                    Kiriakopoulos, E. (n.d.). Focal aware seizures (simple partial seizures). Epilepsy Foundation.

                    Kiriakopoulos, E, et al. (2022). Tonic-clonic seizures. Epilepsy Foundation.

                    Rogawski, M. A., et al. (2015). Current understanding of the mechanism of action of the antiepileptic drug lacosamide. Epilepsy Research.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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