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Matulane

Specialty Drug

Procarbazine

Matulane is part of the Alkylating Drugs class and treats Hodgkin's Disease. Alkylating drugs are used to treat brain tumors, melanoma, Hodgkin's disease, Non-Hodgkin's lymphoma, breast cancer, ovarian cancer, neuroblastoma, leukemia, multiple myeloma, retinoblastoma, and prostate cancer. They work by inhibiting cancer cell growth and slowing it down. Matulane is only available as a brand name drug. Compare alkylating drugs.

Prescription Settings

Matulane Side Effects

Common and Rare Side Effects

Along with their needed effects, medicines like procarbazine can sometimes cause unwanted effects such as blood problems, loss of hair, high blood pressure reactions, and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Rare

Chest pain (severe)

enlarged pupils of eyes

fast or slow heartbeat

headache (severe)

increased sensitivity of eyes to light

increased sweating (possibly with fever or cold, clammy skin)

stiff or sore neck

Check with your doctor immediately if any of the following side effects occur:

Less common

Black, tarry stools

blood in urine or stools

bloody vomit

cough or hoarseness

fever or chills

lower back or side pain

painful or difficult urination

pinpoint red spots on skin

unusual bleeding or bruising

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Confusion

convulsions (seizures)

cough

hallucinations (seeing, hearing, or feeling things that are not there)

missing menstrual periods

shortness of breath

thickening of bronchial secretions

tiredness or weakness (continuing)

Less common

Diarrhea

sores in mouth and on lips

tingling or numbness of fingers or toes

unsteadiness or awkwardness

yellow eyes or skin

Rare

Fainting

skin rash, hives, or itching

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Drowsiness

muscle or joint pain

muscle twitching

nausea and vomiting

nervousness

nightmares

trouble in sleeping

unusual tiredness or weakness

Less common

Constipation

darkening of skin

difficulty in swallowing

dizziness or lightheadedness when getting up from a lying or sitting position

dry mouth

feeling of warmth and redness in face

headache

loss of appetite

mental depression

This medicine may cause a temporary loss of hair in some people. After treatment with procarbazine has ended, normal hair growth should return.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Other alkylating drugs

Velban

Other Conditions

Hodgkin's Disease

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