The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Lack of appetite
- Hair loss
- Fever
Less Common Side Effects
- Stomach pain
- Dizziness
- Blurry vision or other changes in vision
- Skin rash
- Skin color changes
- Nail changes
Cyclophosphamide serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
- Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, throwing up blood, bloody or black and tarry stool
- Kidney or bladder problems: blood in the urine (pink or red urine), painful urination, dark urine
- Heart problems: chest pain, shortness of breath, rapid heartbeat, swelling of the legs or feet
- Severe liver problems: yellowing of the skin or eyes (jaundice), dark urine, right upper stomach pain, nausea, vomiting, tiredness, loss of appetite
- Seizures
Source: DailyMed
The following Cyclophosphamide side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Cough or hoarseness
fever or chills
lower back or side pain
missing menstrual periods
painful or difficult urination
With high doses and/or long-term treatment
Blood in the urine
dizziness, confusion, or agitation
fast heartbeat
joint pain
shortness of breath
swelling of the feet or lower legs
unusual tiredness or weakness
Rare
redness, swelling, or pain at the injection site
sores in the mouth and on the lips
sudden shortness of breath
unusual thirst
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Other Cyclophosphamide articles
Other Alkylating Drugs side effects articles
Why trust our experts?





