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Cyclophosphamide

Cyclophosphamide Side Effects

Jenny Zhang, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Jenny Zhang, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on November 16, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Lack of appetite
  • Hair loss
  • Fever

Less Common Side Effects

  • Stomach pain
  • Dizziness
  • Blurry vision or other changes in vision
  • Skin rash
  • Skin color changes
  • Nail changes

Cyclophosphamide serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
  • Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, throwing up blood, bloody or black and tarry stool
  • Kidney or bladder problems: blood in the urine (pink or red urine), painful urination, dark urine
  • Heart problems: chest pain, shortness of breath, rapid heartbeat, swelling of the legs or feet
  • Severe liver problems: yellowing of the skin or eyes (jaundice), dark urine, right upper stomach pain, nausea, vomiting, tiredness, loss of appetite
  • Seizures

Source: DailyMed

The following Cyclophosphamide side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Cough or hoarseness

fever or chills

lower back or side pain

missing menstrual periods

painful or difficult urination

With high doses and/or long-term treatment

Blood in the urine

dizziness, confusion, or agitation

fast heartbeat

joint pain

shortness of breath

swelling of the feet or lower legs

unusual tiredness or weakness

Less common

Black, tarry stools

pinpoint red spots on the skin

unusual bleeding or bruising

Rare

Frequent urination

redness, swelling, or pain at the injection site

sores in the mouth and on the lips

sudden shortness of breath

unusual thirst

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Darkening of the skin and fingernails

loss of appetite

nausea or vomiting

Less common

Diarrhea

flushing or redness of the face

headache

increased sweating

skin rash, hives, or itching

stomach pain

swollen lips

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Jenny Zhang, PharmD, BCOP, is a board-certified clinical oncology pharmacist working in the San Francisco Bay Area. She has 5 years of experience working as a pharmacist in large academic medical centers, with 4 of those years in oncology.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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