The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Worsening kidney function (26%)
- High blood pressure (19%)
- Diarrhea (19%)
- Headache (15%)
- Low red blood cells (anemia) (12%)
- Cough (11%)
- Urinary tract infection (10%)
- Stomach pain (7%)
- Upset stomach, heartburn (6%)
- Hairloss (alopecia) (6%)
Less Common Side Effects
- Lower belly pain
- Mouth sores
- Fatigue, tiredness
- Tremor, shakiness
- Kidney injury
- Poor appetite
Lupkynis serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Infection: fever and chills, fatigue, muscle aches
- Skin cancer: new growth on your skin, change in a mole, sores that don't heal
Source: DailyMed
The following Lupkynis side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Burning or tingling sensation in hands or feet
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- High potassium level—muscle weakness, fast or irregular heartbeat
- Increase in blood pressure
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Sudden and severe headache, confusion, change in vision, seizures, which may be signs of posterior reversible encephalopathy syndrome (PRES)
- Tremors or shaking
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

