The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Less Common Side Effects
- Headache
- Nausea
- Trouble sleeping
- Low white blood cell counts
- Changes in potassium levels
- Low phosphate levels
- Low magnesium levels
- Higher creatinine levels
- Higher blood sugar levels
Note: Side effects were reported by people who've just received a kidney transplant and are taking Envarsus XR (tacrolimus) with other immunosuppressants.
Envarsus XR serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious infection: fever, cough, chills, sore throat, runny or stuffy nose, body aches, belly pain, nausea, dark urine
- Sudden kidney injury: feeling sick or weak; dehydration; confusion; urinating less than usual; blood in urine; swelling in the legs, ankles, or feet
- Problems affecting the nervous system: seizures, tremors, headache, dizziness, "pins and needles" sensation
- Abnormal heart rhythm (QT prolongation): chest pounding, chest pain, trouble breathing, feeling faint or lightheaded
- Bleeding: bleeding that's difficult to stop, vomiting blood, blood in the urine or stool
- Serious blood clot: chest or arm pain; trouble breathing; sweating; dizziness; confusion; headache; sudden numbness or weakness on one side of the body
Source: DailyMed
The following Envarsus XR side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dizziness, loss of balance or coordination, confusion or trouble speaking
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
- High potassium level—muscle weakness, fast or irregular heartbeat
- Increase in blood pressure
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Stomach pain, bloody diarrhea, pale skin, unusual weakness or fatigue, decrease in the amount of urine, which may be signs of hemolytic uremic syndrome
- Sudden and severe headache, confusion, change in vision, seizures, which may be signs of posterior reversible encephalopathy syndrome (PRES)
- TTP—purple spots on the skin or inside the mouth, pale skin, yellowing skin or eyes, unusual weakness or fatigue, fever, fast or irregular heartbeat, confusion, change in vision, trouble speaking, trouble walking
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Diarrhea
- Pain, tingling, or numbness in the hands or feet
- Tremors or shaking
- Trouble sleeping
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