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Clotrimazole / Betamethasone Coupon - Clotrimazole / Betamethasone 45g of 1%/0.05% tube of cream

clotrimazole / betamethasone

Generic Lotrisone
Used for Athlete's Foot, Ringworm, Jock Itch
Used for Athlete's Foot, Ringworm, Jock Itch

Lotrisone (clotrimazole / betamethasone) is a prescription combination medication containing clotrimazole (an antifungal) and betamethasone (a corticosteroid). It's applied to the skin to treat conditions like athlete's foot, ringworm, and jock itch. Children under age 17 years old shouldn't use Lotrisone (clotrimazole / betamethasone) due to the risk of serious corticosteroid-related side effects, such as hormone changes, growth problems, and skin problems.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on February 8, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Lotrisone (clotrimazole / betamethasone)?

What is Lotrisone (clotrimazole / betamethasone) used for?

How Lotrisone (clotrimazole / betamethasone) works

Lotrisone (clotrimazole / betamethasone) is a combination of two medications that treat fungal infections.

  • Clotrimazole is an azole antifungal that works by stopping the fungus from being able to make a protective covering. This makes it difficult for the fungus to grow or survive.

  • Betamethasone is a corticosteroid that is like cortisol, a natural hormone your body makes. It lowers certain chemicals in your body that cause inflammation (swelling, redness, and itchiness) in your skin.

Are you looking for information on clotrimazole (Lotrimin AF) or betamethasone (Diprolene) topical instead?
When does Lotrisone (clotrimazole / betamethasone) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsLotrisone
Drug ClassAntifungal / Corticosteroid
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Lotrisone (clotrimazole / betamethasone)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Tingling or numbness
  • Rash
  • Swelling
  • Infection
When do Lotrisone (clotrimazole / betamethasone) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Tingling or numbness
Rash
Swelling

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blistering, burning, itching, peeling, dryness, redness, or other signs of skin irritation not present before use of this medicine

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

hives

Rare

Chills

cough

fever

hoarseness

lower back or side pain

painful or difficult urination

rash

stinging

swelling

Incidence not known

Blindness

blurred vision

change in vision

decreased vision

dry mouth

eye pain

full or round face, neck, or trunk

headache

irritability

nausea

reddish purple lines on the arms, face, legs, trunk, or groin

redness and scaling around the mouth

softening of the skin

stomach pain

tearing

unusual tiredness or weakness

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Lotrisone (clotrimazole / betamethasone)

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Pros

Lotrisone (clotrimazole / betamethasone) cream works better at getting rid of the fungal infection than clotrimazole cream alone alone

Easier to use a product that's a combination of two medications

Available as a lower-cost generic

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Cons

Not meant for long-term use

Can raise your risk of developing serious side effects (e.g., cataracts, hormone changes) if used for too long

Not a good choice for children under 17 years old because of steroid-related side effects

pharmacist-tips

Pharmacist tips for Lotrisone (clotrimazole / betamethasone)

pharmacist

  • Lotrisone (clotrimazole / betamethasone) contains a moderate-to-high potency steroid, depending on whether you're prescribed the lotion or the cream. Only use the least amount of medication possible for the shortest amount of time to avoid side effects, such as skin thinning and irritation. Only use Lotrisone (clotrimazole / betamethasone) as prescribed by your provider.

    • Don't apply other topical steroid or antifungal medications while using Lotrisone (clotrimazole / betamethasone) unless your provider specifically said it was safe for you to do so.

      • Only apply Lotrisone (clotrimazole / betamethasone) onto your skin. Don't apply it on broken skin, near your eyes, or in your mouth or vagina. Applying Lotrisone (clotrimazole / betamethasone) to these sensitive areas can cause pain and more medication to be absorbed into your body, which can raise your risk of side effects.

        • Before applying Lotrisone (clotrimazole / betamethasone), wash and dry the affected areas of your skin well. Make sure to rub in the medication gently and then wash your hands well after you're done.

          • After applying, don't place bandages or dressings over the areas where Lotrisone (clotrimazole / betamethasone) is applied unless your provider has instructed you to do so. This can cause more medication to get absorbed into your body than intended and raise your risk of side effects.

            • Make sure to apply Lotrisone (clotrimazole / betamethasone) for the entire time your prescriber told you to. Stopping treatment too early can cause your infection to come back or be harder to treat.

              • Wash your hands well after applying Lotrisone (clotrimazole / betamethasone) to prevent it from getting in your eyes. If Lotrisone (clotrimazole / betamethasone) gets in your eyes, rinse them well with water.

                • You should begin to see improvement in your symptoms within 1 to 2 weeks of starting Lotrisone (clotrimazole / betamethasone) treatment, depending on what condition you're being treated for. If not, let your provider know so they can decide whether you should continue to apply this medication or consider other options

                  • If you're applying Lotrisone (clotrimazole / betamethasone) to treat athlete's foot, be sure to wear shoes that fit well and circulate air, and change your shoes and socks daily. This will help your infection clear up as quickly as possible.

                    faqs

                    Frequently asked questions about Lotrisone (clotrimazole / betamethasone)

                    How well does Lotrisone (clotrimazole / betamethasone) work?
                    In clinical studies of Lotrisone (clotrimazole / betamethasone) cream, people saw their infections improving 3 to 5 days after (for ringworm and jock itch) and 1 week after (for athlete's foot) starting treatment. Additionally, people who applied Lotrisone (clotrimazole / betamethasone) cream had better improvement in their infection, including higher cure rates, than those who applied betamethasone dipropionate cream alone. The studies also showed that Lotrisone (clotrimazole / betamethasone) cream worked just as well, if not better, at curing infections compared to clotrimazole cream alone.
                    How long can I use Lotrisone (clotrimazole / betamethasone)?
                    If you're prescribed Lotrisone (clotrimazole / betamethasone) for ringworm or jock itch, don't use it for longer than 2 weeks. You should start to see your symptoms get better within 1 week of using Lotrisone (clotrimazole / betamethasone), but if you don't, contact your provider. If you're apply Lotrisone (clotrimazole / betamethasone) to treat athlete's foot, you can use this medication for up to 4 weeks. But if your symptoms don't improve after 2 weeks, contact your provider.
                    Can I use Lotrisone (clotrimazole / betamethasone) to treat dry skin?
                    No, Lotrisone (clotrimazole / betamethasone) isn't a cream that's used for treating dry skin. Lotrisone (clotrimazole / betamethasone) contains a steroid and an antifungal, and is only FDA-approved to treat topical fungal infections, like athlete's foot, ringworm, and jock itch. There are several other medications that are specifically used for dry skin. Ask your provider or pharmacist for a recommendation if you aren't sure which is best for you.
                    Can I use Lotrisone (clotrimazole / betamethasone) if I'm pregnant?
                    It's not completely clear whether it's safe to apply Lotrisone (clotrimazole / betamethasone) during pregnancy. Lotrisone (clotrimazole / betamethasone) contains betamethasone 0.05% cream or lotion, which is considered a medium-to-high-potency steroid. Studies show that high-potency steroids can raise the risk for babies to have low weight at birth. However, other studies show that this isn't very likely. Make sure to tell your provider if you're pregnant before starting Lotrisone (clotrimazole / betamethasone). If your provider thinks the benefits of Lotrisone (clotrimazole / betamethasone) for you is greater than the risk of harm to you and your baby, they'll recommend that you apply this medication to the smallest skin area necessary for the shortest amount of time possible.
                    Can I use Lotrisone (clotrimazole / betamethasone) if I'm breastfeeding?
                    Discuss the risks and benefits of this medication with your provider if you're breastfeeding. There isn't information about whether or not Lotrisone (clotrimazole / betamethasone) can pass into breastmilk. To be safe, your provider will likely recommend that you apply this medication to the smallest skin area necessary for the shortest amount of time possible. Don't apply Lotrisone (clotrimazole / betamethasone) directly to the breast area to prevent your baby getting the medication in their mouth during breastfeeding.
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                    What are the risks and warnings for Lotrisone (clotrimazole / betamethasone)?

                    Lotrisone (clotrimazole / betamethasone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Altered stress hormone levels

                    • Risk factors: Applying Lotrisone (clotrimazole / betamethasone) to large areas of the body | Applying Lotrisone (clotrimazole / betamethasone) for a long time | Covering the medicated area | Damaged skin | Liver problems | Children

                      If you apply Lotrisone (clotrimazole / betamethasone) to larger areas of skin over longer periods of time, this can cause your body to absorb too much medication. Having too much Lotrisone (clotrimazole / betamethasone) in your body can cause your body to make less stress hormones. This can affect many important bodily functions and lead to symptoms such as tiredness, nausea, muscle aches. This problem usually goes away after you stop using Lotrisone (clotrimazole / betamethasone), but you might need additional medical treatment if it's severe.

                      Apply Lotrisone (clotrimazole / betamethasone) only as directed. Don't apply too much of the medication and don't use it for a longer period of time than prescribed. Don't cover the medicated area with bandages or dressings unless your provider tells you to do so. If your provider thinks that Lotrisone (clotrimazole / betamethasone) is affecting your body's hormone production, then they might recommend that you apply this medication less frequently or switch you to a different medication.

                      risk-warning

                      Cataracts and glaucoma

                      • Risk factors: History of cataracts or glaucoma | Vision issues

                        Though rare, Lotrisone (clotrimazole / betamethasone) can raise your risk of developing vision problems, like cataracts or glaucoma. Make sure your provider knows if you have any issues with your vision or eyes before you start using this medication. If you start noticing vision problems while you are using Lotrisone (clotrimazole / betamethasone), let your healthcare provider know.

                        dosage

                        Lotrisone (clotrimazole / betamethasone) dosage forms

                        Typical dosing for Lotrisone (clotrimazole / betamethasone)

                        • Athlete's foot: Apply a thin layer to the affected area(s) twice daily for 2 weeks. The maximum weekly dose is 45 grams of cream (or 45 mL of lotion) per week. Don't use longer than 4 weeks.

                        • Ringworm and jock itch: Apply a thin layer to the affected area(s) twice daily for 1 week. The maximum weekly dose is 45 grams of cream (or 45 mL of lotion) per week. Don't use longer than 2 weeks.

                        interactions

                        Interactions between Lotrisone (clotrimazole / betamethasone) and other drugs

                        Lotrisone (clotrimazole / betamethasone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Lotrisone (clotrimazole / betamethasone). Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                        How much does Lotrisone (clotrimazole / betamethasone) cost?

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                        alternatives

                        What are alternatives to Lotrisone (clotrimazole / betamethasone)?

                        There are a number of medications that your doctor can prescribe in place of Lotrisone (clotrimazole / betamethasone). Compare a few possible alternatives below.
                        Lotrisone (clotrimazole / betamethasone)
                        Used for:
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                        Clotrimazole (Lotrimin AF)
                        Used for:
                        $13.11 Lowest GoodRx priceView Prices
                        Naftifine gel (Naftin)
                        Used for:
                        $69.56 Lowest GoodRx priceView Prices
                        images

                        Lotrisone (clotrimazole / betamethasone) images

                        white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        This medicine is White Tube Of Cream.white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        This medicine is White Tube Of Cream.white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        This medicine is White Tube Of Cream.white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        This medicine is White Tube Of Cream.white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream
                        This medicine is White Tube Of Cream.white - Clotrimazole / Betamethasone Dipropionate 1%-0.05% Topical Cream

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                        References

                        Best studies we found

                        Alexandraki, K. I., et al. (2018). Adrenal suppression. Endotext.

                        Andersson, N. W., et al. (2021). Evaluation of topical corticosteroid use in pregnancy and risk of newborns being small for gestational age and having low birth weight. JAMA Dermatology.

                        Taro Pharmaceuticals U.S.A., Inc. (2022). Clotrimazole and betamethasone dipropionate cream [package insert]. DailyMed.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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