What's the difference between levamlodipine (Conjupri) and amlodipine (Norvasc)?

Levamlodipine (Conjupri) and [amlodipine (Norvasc)](https://www.goodrx.com/amlodipine/what-is) are both calcium channel blockers that work well to lower blood pressure. The main difference is in the chemical structure of both medications. Amlodipine (Norvasc) contains a mix of 2 different types of the same active ingredient. On the other hand, levamlodipine (Conjupri) only contains one type of the active ingredient. [Studies](https://www.hindawi.com/journals/ijhy/2018/8681792/) show that (levamlodipine (Conjupri)) works just as well as amlodipine (Norvasc) at just half the dose, so the dose of levamlodipine (Conjupri) is half the dose of amlodipine (Norvasc). Levamlodipine (Conjupri) might also be better tolerated with cause fewer side effects compared to amlodipine (Norvasc). Ask your provider to see which blood pressure medication is right for you.

levamlodipine

Q: Can I use levamlodipine (Conjupri) with my other blood pressure medications?

Yes. Levamlodipine (Conjupri) is FDA approved to be used either on its own or together with your other blood pressure medications. Oftentimes people need multiple medications to treat high blood pressure. Combination therapy, or taking medications from different medication classes at the same time, can help you reach your blood pressure goals. This is because each medication in your regimen can lower your blood pressure by attacking it from different sides.

Q: Can I use levamlodipine (Conjupri) if I have liver problems?

Probably, but your dose of levamlodipine (Conjupri) might be different. If you have liver problems, you might start by using a smaller dose of the medication (1.25 mg) a day. If your dose needs to be raised, your provider will do so at a much slower pace. This is because the liver is responsible for getting rid of levamlodipine (Conjupri) in your body. People with liver problems tend to have a build up of the medication which can put them at risk for side effects.

Q: Can I use levamlodipine (Conjupri) if I'm pregnant?

There haven't been enough studies in humans looking at how levamlodipine (Conjupri) affects unborn babies, so it's not completely known how safe it is. But poorly controlled high blood pressure during pregnancy can be a problem for both the mother and the unborn baby. If you're pregnant, talk to your provider to see if levamlodipine (Conjupri) is safe for you and your unborn baby.

Generic Conjupri

Used for Hypertension

Levamlodipine (Conjupri) is used to treat high blood pressure in children and adults. It's similar to amlodipine (Norvasc), a more common blood pressure medication, but is chemically different and generally more expensive.

Reviewed by:

Robert Chad Hakim, PharmD, BCCCP

Allison Gourley, PharmD

Last reviewed on July 21, 2022

What is Levamlodipine (Conjupri)?

What is Levamlodipine (Conjupri) used for?

High blood pressure

How Levamlodipine (Conjupri) works

Levamlodipine (Conjupri) is a calcium channel blocker (CCB). It works by blocking calcium from flowing into your blood vessels. This causes your vessels to relax and dilate (open up), which lowers your blood pressure.

Drug facts

Common Brands	Conjupri
Drug Class	Calcium channel blocker (CCB)
Controlled Substance Classification	Not a controlled medication
Generic Status	Lower-cost generic available
Availability	Prescription only

Common Brands

Conjupri

Drug Class

Calcium channel blocker (CCB)

Controlled Substance Classification

Not a controlled medication

Generic Status

Lower-cost generic available

Availability

Prescription only

Side effects of Levamlodipine (Conjupri)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Swelling (2-11%)
Tiredness (5%)
Fast heart rate (1-5%)
Nausea (3%)
Dizziness (1-3%)
Flushing (1-3%)
Stomach pain (2%)

Less Common Side Effects

Slow heart rate
Fainting
Constipation
Tremor
Back pain
Weight changes
Anxiety
Trouble breathing
Dry mouth

Levamlodipine (Conjupri) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

Low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
Chest pain or heart attack: radiating jaw pain, crushing chest pain, fast heartbeat, chest pain

Source: DailyMed

The following Levamlodipine (Conjupri) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
Worsening chest pain (angina)—pain, pressure, or tightness in the chest, neck, back, or arms

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

Facial flushing, redness
Heart palpitations—rapid, pounding, or irregular heartbeat
Nausea
Stomach pain
Swelling of the ankles, hands, or feet

Get your GoodRx coupon

Avg retail price

$97.73(Save 62.69%)

$36.46

See prices

Pros and cons of Levamlodipine (Conjupri)

Pros

Taken just once a day
Can be used in children as young as 6 years old
Can be taken with or without food

Cons

Can sometimes cause blood pressure that's too low
Can cause swelling in the body
Interacts with many commonly used medications

Pharmacist tips for Levamlodipine (Conjupri)

Take levamlodipine (Conjupri) with or without food at any time of day.
You might notice side effects when you start taking levamlodipine (Conjupri) and when the dose is raised. But side effects should get better over time as you continue taking the medication.
Levamlodipine (Conjupri) can interact with commonly used medications like simvastatin (Zocor) or sildenafil (Viagra). Make sure to tell your provider about all the medications you're taking before starting levamlodipine (Conjupri). Additionally, don't start any new medications without talking to your provider or pharmacist first.
Levamlodipine (Conjupri) can cause swelling (edema) in your feet, ankles, legs, hands, or arms. Swelling can be worse if you have other conditions that make it hard for your body to get rid of fluids like congestive heart failure (CHF) or kidney problems. Talk to your provider if the swelling becomes too bothersome.

Common questions about Levamlodipine

Levamlodipine and amlodipine (Norvasc) are both calcium channel blockers that work well to lower blood pressure. The main difference is in the chemical structure of both medications. Amlodipine (Norvasc) contains a mix of 2 different types of the same active ingredient. On the other hand, Levamlodipine only contains one type of the active ingredient. Studies show that (Levamlodipine) works just as well as amlodipine (Norvasc) at just half the dose, so the dose of Levamlodipine is half the dose of amlodipine (Norvasc). Levamlodipine might also be better tolerated with cause fewer side effects compared to amlodipine (Norvasc). Ask your provider to see which blood pressure medication is right for you.

Yes. Levamlodipine is FDA approved to be used either on its own or together with your other blood pressure medications. Oftentimes people need multiple medications to treat high blood pressure. Combination therapy, or taking medications from different medication classes at the same time, can help you reach your blood pressure goals. This is because each medication in your regimen can lower your blood pressure by attacking it from different sides.

Probably, but your dose of Levamlodipine might be different. If you have liver problems, you might start by using a smaller dose of the medication (1.25 mg) a day. If your dose needs to be raised, your provider will do so at a much slower pace. This is because the liver is responsible for getting rid of Levamlodipine in your body. People with liver problems tend to have a build up of the medication which can put them at risk for side effects.

There haven't been enough studies in humans looking at how Levamlodipine affects unborn babies, so it's not completely known how safe it is. But poorly controlled high blood pressure during pregnancy can be a problem for both the mother and the unborn baby. If you're pregnant, talk to your provider to see if Levamlodipine is safe for you and your unborn baby.

Risks and warnings for Levamlodipine (Conjupri)

Levamlodipine (Conjupri) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Severely low blood pressure

Risk factors: History of narrow heart valves (aortic stenosis)

Levamlodipine (Conjupri) can cause your blood pressure to drop too much, which can make you feel dizzy, tired, or lightheaded. This is common with blood pressure medications like levamlodipine (Conjupri), especially when starting the medication and when the dose is raised. Your risk is higher if you have a history of aortic stenosis (narrow heart valves). If your blood pressure drops too much and you fall or you feel too dizzy, make sure to sit down slowly while holding onto something and let your provider know. If you fall and hit your head, get medical help right away.

Heart attack and chest pain

Risk factors: History of coronary artery disease

Worsening chest pain or a heart attack is possible when you first start taking levamlodipine (Conjupri). This can also happen after your dose is raised. Your risk is higher if you have a heart problem called coronary artery disease. Get medical attention right away if you experience any chest pain, radiating jaw pain, crushing chest pain, or a fast heartbeat.

Levamlodipine (Conjupri) dosage

The average cost for 90 tablets of 2.5mg of Levamlodipine (Conjupri) is $207.71 with a free GoodRx coupon. This is 19.82% off the average retail price of $259.06.

Tablet

Dosage	Quantity	Price as low as	Price per unit
2.5mg	90 tablets	$207.71	$2.31
5mg	30 tablets	$36.46	$1.22

Typical dosage for Levamlodipine (Conjupri)

Adults age 18 years and older: The typical starting dose is 2.5 mg by mouth once a day. The maximum dose is 5 mg by mouth once a day.
Adults who are small, fragile, older, or those with liver problems: The typical starting dose is 1.25 mg by mouth once a day.
Children age 6 to 17 years: The typical starting dose is 1.25 mg to 2.5 mg once a day. The maximum dose is 2.5 mg by mouth once a day.

Your provider will adjust your dose based on how well the medication is working for you and whether or not you have side effects. Your dose might differ if you have liver problems.

How much does Levamlodipine (Conjupri) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.

Conjupri (brand)

GoodRx lowest price

$36.46

(save 95.35%)

Levamlodipine (Conjupri) (generic)

GoodRx lowest price

$36.46

(save 85.93%)

View prices and coupons

Levamlodipine (Conjupri) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Levamlodipine (Conjupri) will not be safe for you to take.