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Hydrocodone / Homatropine Coupon - Hydrocodone / Homatropine 473ml of 5mg/1.5mg/5ml syrup

hydrocodone / homatropine

Generic Hydromet
Used for Cough
Used for Cough

Hydromet is a combination medication that contains hydrocodone (an opioid) and homatropine (an anticholinergic). It helps ease cough in adults by lowering the urge to cough. But Hydromet (hydrocodone / homatropine) isn't a first-choice option for this condition because it's a controlled substance and can cause serious side effects, such as trouble breathing. Hydromet (hydrocodone / homatropine) is taken by mouth, typically every 6 hours as needed. Some common side effects of this medication include sleepiness, trouble thinking clearly, and constipation. Hydromet (hydrocodone / homatropine) is available as a generic medication.

Last reviewed on June 12, 2024
Hydromet (hydrocodone / homatropine) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Hydromet (hydrocodone / homatropine)?

What is Hydromet (hydrocodone / homatropine) used for?

  • Treatment of cough in adults

How Hydromet (hydrocodone / homatropine) works

Hydromet (hydrocodone / homatropine) is a combination of two medications:

Are you looking for information on Hycodan (hydrocodone / homatropine) and Norco (hydrocodone / acetaminophen) instead?
When does Hydromet (hydrocodone / homatropine) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsHydromet
Drug ClassOpioid / Anticholinergic
Controlled Substance ClassificationSchedule II
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the risks and warnings for Hydromet (hydrocodone / homatropine)?

Hydromet (hydrocodone / homatropine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Potential for misuse and addiction

  • Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health conditions

    Hydromet contains an opioid medication (hydrocodone), which carries a risk of addiction or misuse, even at recommended doses. In serious cases, addiction and misuse of an opioid medication can lead to overdose and death.

    Hydromet (hydrocodone / homatropine) is typically prescribed only when cough relief outweigh these serious risks. If absolutely necessary, your healthcare professional (HCP) will prescribe the lowest amount of medication for the shortest period of time needed to treat your symptoms. Contact your HCP to discuss other options if you've taken Hydromet (hydrocodone / homatropine) for 5 days and your cough hasn't gotten better.

    risk-warning

    Dangerously slow breathing (respiratory depression)

    • Risk factors: Older adults | Children younger than 18 years old | Taking medications that can cause slow breathing | Brain injury | Drinking alcohol | Having medical conditions that affect breathing | Taking higher doses of Hydromet (hydrocodone / homatropine) than prescribed

      Hydromet (hydrocodone / homatropine) can cause dangerously slow breathing, which can be life-threatening. This can happen at any time, but you're at higher risk 1 to 3 days right after you start Hydromet (hydrocodone / homatropine). Drinking alcohol and taking other medications, like benzodiazepines, can also raise your risk for this dangerous side effect.

      You're recommended to ask your prescriber about getting naloxone, a medication that can reverse slowed breathing from opioids. You should have naloxone before you start Hydromet (hydrocodone / homatropine) so that you can use it in case of an accidental overdose. Call 911 to get medical help right away if you or your loved one notices you have trouble breathing or have bluish-colored lips.

      risk-warning

      Difficulty concentrating and extreme sleepiness

      • Risk factors: Taking higher doses of Hydromet (hydrocodone / homatropine) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness

        Hydromet (hydrocodone / homatropine) can cause extreme sleepiness and lower your ability to think, react, and focus. Your risk for these side effects is higher if you're taking other medications that can make you sleepy, such as benzodiazepines, muscle relaxants, and sleep medications.

        Make sure you know how Hydromet (hydrocodone / homatropine) affects you before driving a car or doing activities that require your concentration. Talk to your HCP right away if you feel too sleepy from the medication.

        risk-warning

        Risk for overdose

        • Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of Hydromet (hydrocodone / homatropine) | Taking more opioids or antihistamines than prescribed | Drinking alcohol

          Take Hydromet (hydrocodone / homatropine) exactly as prescribed. Taking too much medication or taking it more often than prescribed can lead to an overdose. When measuring out your dose of Hydromet (hydrocodone / homatropine), only use a oral syringe or a medication cup; don't use household spoons because they might not be accurate. Be sure to keep the opioid medication out of reach from children, pets, or visitors to prevent accidental exposure or overdose. Don't drink alcohol while taking Hydromet (hydrocodone / homatropine) because doing so raises the risk for overdose.

          Symptoms of an opioid overdose include not responding to sound or touch, extremely slow breathing, extreme sleepiness, slow heartbeat, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will probably write a prescription for naloxone (Narcan), a medication that can treat an opioid overdose. Carry naloxone with you at all times; use it and call 911 right away if an overdose happens.

          Additionally, anticholinergic medications can be found in some over-the-counter products, such as diphenhydramine (Benadryl). Very rarely, taking too much anticholinergic medication can lead to side effects such as confusion, delirium, skin flushing, and fever. To prevent an accidental overdose, read package labels carefully. Ask your pharmacist if you're not sure whether a product has an anticholinergic in it.

          risk-warning

          Drug interactions

          Hydromet (hydrocodone / homatropine) interacts with a lot of common medications. So it's important to tell your prescriber and pharmacist about the medications you're taking and planning to take with Hydromet (hydrocodone / homatropine). Your care team can check that your medications are safe to take together. Also talk to your care team first before making any changes to your medications because sudden dose adjustments can also lead to harm.

          Some interactions can raise the level of hydrocodone in your body. This can raise your risk for serious side effects, including potentially life-threatening slowed breathing. Examples of medications that can lead to this type of interaction with Hydromet (hydrocodone / homatropine) include erythromycin, ketoconazole, and ritonavir (Norvir).

          Other drug interactions can lower the levels of hydrocodone in your body. This can cause the opioid to work less well for you and possibly lead to withdrawal symptoms. These interactions include taking Hydromet (hydrocodone / homatropine) with rifampin (Rifadin) or carbamazepine (Tegretol).

          risk-warning

          Harm to newborn babies

          Hydromet (hydrocodone / homatropine) can be transferred to your unborn baby if you take this medication during pregnancy. Long-term opioid use during pregnancy can cause your unborn baby to become dependent on the medication.

          Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding and sucking behavior, trembling, irritability, abnormal sleep patterns, and seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your healthcare team know if you've used Hydromet (hydrocodone / homatropine) during pregnancy or if you notice these symptoms in your baby.

          risk-warning

          Low blood pressure

          Hydromet (hydrocodone / homatropine) can cause extremely low blood pressure. Your blood pressure might drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to your HCP if any dizziness or lightheadedness doesn't go away.

          risk-warning

          Low adrenal hormone levels

          • Risk factors: Taking Hydromet (hydrocodone / homatropine) for longer than 1 month

            Some people taking opioid medications like Hydromet (hydrocodone / homatropine) have had low adrenal hormone levels. This might be more likely to happen after taking opioids for longer than 1 month. Symptoms include tiredness, dizziness, weakness, not feeling hungry, nausea, and vomiting. Tell your HCP if you have these symptoms. If your adrenal hormone levels are too low, you might need to stop Hydromet (hydrocodone / homatropine) and be treated with corticosteroids.

            risk-warning

            Seizures

            • Risk factors: History of seizure conditions

              Opioids such as hydrocodone can raise the risk of having seizures more often in people who have had seizures in the past. Hydromet (hydrocodone / homatropine) can also raises your risk of seizures in certain situations. Get medical help right away if you have a seizure while you're taking this medication.

              risk-warning

              Caution in people with gut-related conditions

              Hydromet (hydrocodone / homatropine) can cause your gut movement to slow and can lead to constipation or bowel obstruction. This medication shouldn't be taken by people who already have bowel obstruction or conditions related to gut movement. To lower your risk of constipation, drink enough fluids and eat foods that are rich in fiber, such as broccoli, apples, almonds. Get medical attention right away if you experience symptoms related to bowel obstruction, such as serious stomach pains, bloating, or nausea.

              basics-icon

              What are the side effects of Hydromet (hydrocodone / homatropine)?

              The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

              Common Side Effects

              • Sleepiness
              • Trouble thinking clearly
              • Trouble walking or performing tasks
              • Lightheadedness
              • Dizziness
              • Headache
              • Dry mouth
              • Nausea
              • Vomiting
              • Constipation

              Other Side Effects

              • Flushing
              • Itching
              • Rash
              • Stomach pain
              • Low appetite

              Serious Side Effects

              Contact your healthcare provider immediately if you experience any of the following.
              • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
              • Accidentally taking too much (overdose): not responding to sound or touch, slow breathing, extreme sleepiness, cold or clammy skin, slow or irregular heartbeat, confusion, seizure
              • Opioid withdrawal (if suddenly stopped after long-term use): anxiety, suicidal thoughts, restlessness, runny nose, yawning, sweating, chills, wide pupils, irritability
              • Excessive sleepiness or dizziness
              • Seizures
              When do Hydromet (hydrocodone / homatropine) possible side effects begin and end?
              Time passed since treatment started:
              MINUTES
              HOURS
              DAYS
              WEEKS
              MONTHS
              Sleepiness
              Dizziness
              Lightheadedness
              Dry mouth
              Nausea and vomiting
              Risk for slowed breathing
              Seek immediate medical care if you experience this side effect.
              If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

              Source: DailyMed

              The following side effects have also been reported

              Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

              Check with your doctor immediately if any of the following side effects occur:

              Less common

              Bladder pain

              bloating or swelling of the face, arms, hands, lower legs, or feet

              bloody or cloudy urine

              body aches or pain

              chills

              cough

              depression

              difficult or labored breathing

              difficult, burning, or painful urination

              ear congestion

              fear or nervousness

              fever

              frequent urge to urinate

              headache

              loss of voice

              lower back or side pain

              nasal congestion

              rapid weight gain

              runny nose

              sneezing

              sore throat

              tightness in the chest

              tingling of the hands or feet

              unusual tiredness or weakness

              unusual weight gain or loss

              Incidence not known

              Agitation

              darkening of the skin

              diarrhea

              difficulty swallowing

              fast heartbeat

              hives, itching, skin rash

              loss of appetite

              mental depression

              nausea

              overactive reflexes

              poor coordination

              puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

              restlessness

              shivering

              talking or acting with excitement you cannot control

              trembling or shaking

              twitching

              vomiting

              Get emergency help immediately if any of the following symptoms of overdose occur:

              Symptoms of overdose

              Blue lips and fingernails

              blurred vision

              change in consciousness

              chest pain or discomfort

              cold and clammy skin

              confusion

              constricted pupil (black part of the eye)

              coughing that sometimes produces a pink frothy sputum

              decreased awareness or responsiveness

              dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

              increased sweating

              irregular, fast or slow, or shallow breathing

              lightheadedness, dizziness, or fainting

              pale skin

              sleepiness or unusual drowsiness

              slow or irregular heartbeat

              weak muscle tone

              Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

              More common

              Difficulty having a bowel movement

              Less common

              Back pain

              dry mouth

              heartburn

              muscle spasms

              stomach pain or discomfort

              Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

              Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

              pros-and-cons

              Pros and cons of Hydromet (hydrocodone / homatropine)

              thumbs-up

              Pros

              Liquid medication, so good option for people who've trouble swallowing tablets

              Can be taken as needed for cough

              thumbs-down

              Cons

              Can be habit-forming

              Can cause slowed or abnormal breathing, which can be dangerous

              Only provides relief for the cough, but doesn't help the actual cause of the cough

              pharmacist-tips

              Pharmacist tips for Hydromet (hydrocodone / homatropine)

              pharmacist
              • Take Hydromet (hydrocodone / homatropine) with or without food. But taking the medication with food can help prevent or ease stomach upset.

                • Let your prescriber know if your cough doesn't get better after taking Hydromet (hydrocodone / homatropine) for 5 days. If this medication isn't helping your cough after 5 days, then your healthcare team will talk with you about other options. Continuing Hydromet when it isn't work well for you can raise your risk for dependence and serious side effects, such as sleepiness and breathing problems.

                  • Store Hydromet (hydrocodone / homatropine) at room temperature. Make sure to use the plastic dosing spoon, medication dosing cup, or oral syringe that the pharmacy provides you to measure out your dose. Don't use household teaspoons; using them might cause you to take the wrong amount of medication.

                    • Hydromet (hydrocodone / homatropine) causes dizziness, sleepiness, and trouble focusing or concentrating. Avoid activities that require you to be alert, like driving, until you know how the medication affects you.

                      • Avoid drinking alcohol while taking Hydromet (hydrocodone / homatropine). Doing so can worsen side effects like sleepiness and dizziness. Both alcohol and Hydromet (hydrocodone / homatropine) can also cause you to have trouble thinking clearly and reacting quickly.

                        • It's common to have constipation as a side effect while you're taking Hydromet (hydrocodone / homatropine). Drink enough water each day and add more foods with fiber to your diet. Speak to your care team if these lifestyle changes aren't enough to help with this side effect.

                          • Tell your prescriber and pharmacist about all the medications you're taking to make sure Hydromet (hydrocodone / homatropine) is safe to take with them. Several medications can interact with both hydrocodone and homatropine, and these interactions can be harmful.

                            • Talk with your prescriber if you've been regularly taking Hydromet (hydrocodone / homatropine) for a long period of time and you want to stop. Your prescriber might lower your dose slowly over time before you can stop completely. This helps prevent opioid withdrawal symptoms, such as anxiety, sweating, chills, and irritability, which can happen after lowering your dose or stopping the medication too suddenly.

                              • Let your prescriber know if you're pregnant before you start taking Hydromet (hydrocodone / homatropine) or if you become pregnant while you're taking this medication. Hydromet (hydrocodone / homatropine) is generally not recommended during pregnancy. Doing so puts your baby at risk for neonatal opioid withdrawal syndrome at birth, and this condition can be life-threatening.

                                • Tell your healthcare team if you're breastfeeding. It's typically recommended to avoid Hydromet (hydrocodone / homatropine) because hydrocodone can get into breast milk. This raises the risk for serious side effects to your baby (e.g., sleepiness, slowed breathing).

                                  • Store Hydromet (hydrocodone / homatropine) out of reach from children, pets, or visitors. Contact a pharmacist about how to get rid of it safely if you don't need to take the medication anymore. This lowers the risk of accidental overdose and helps prevent medication misuse.

                                    faqs

                                    Frequently asked questions about Hydromet (hydrocodone / homatropine)

                                    How long does Hydromet (hydrocodone / homatropine) take to work?
                                    Hydromet (hydrocodone / homatropine) will likely start to relieve your cough within a few hours after your dose. But if your cough doesn't get better within 5 days of starting Hydromet (hydrocodone / homatropine), let your care team know. This is likely a sign that Hydromet (hydrocodone / homatropine) won't work well for you and continuing this medication will only raise your risk for dependence and other serious side effects, like dizziness and trouble breathing. Your healthcare team can examine you to see if there are better options to treat your cough.
                                    How long does Hydromet (hydrocodone / homatropine) stay in your system?
                                    It takes about a day for most of Hydromet (hydrocodone / homatropine) to leave your body after a single dose. This time frame is estimated based on the half-life of the medication. It might differ from person to person based on other factors, such as genetics and whether or not you have kidney problems.
                                    Is Hydromet (hydrocodone / homatropine) an opioid?
                                    Yes. Hydromet (hydrocodone / homatropine) is a combination medication that includes an opioid called hydrocodone. The other ingredient in this combination medication is homatropine, which is an anticholinergic medication.
                                    Is Hydromet (hydrocodone / homatropine) habit-forming?
                                    Yes. Hydromet contains hydrocodone, an opioid that can habit-forming. Because of this, Hydromet (hydrocodone / homatropine) has a black box warning for risk of addiction and dependence and is a schedule II controlled substance, just like other opioids. To lower the risk for addiction and dependence, take Hydromet (hydrocodone / homatropine) exactly as prescribed to you. Your HCP will also prescribe the lowest dose for the shortest period of time needed to treat your condition.
                                    Can you take ibuprofen (Advil) with Hydromet (hydrocodone / homatropine)?
                                    Ibuprofen (Advil) doesn't have any known interactions with Hydromet (hydrocodone / homatropine). But keep in mind that ibuprofen (Advil) isn't safe for everyone. For example, it's not a good option for people with certain medical conditions, such as heart failure or kidney problems. Before you take ibuprofen (Advil) with Hydromet (hydrocodone / homatropine), speak with a healthcare professional or pharmacist to make sure it's safe for you to take them together.
                                    Can you take acetaminophen (Tylenol) with Hydromet (hydrocodone / homatropine)?
                                    Speak with your healthcare professional (HCP) to make sure it's safe for you to take acetaminophen (Tylenol) and Hydromet (hydrocodone / homatropine). Acetaminophen (Tylenol) doesn't have any major interactions with Hydromet (hydrocodone / homatropine). But acetaminophen (Tylenol has has a risk for causing liver problems, so it's not the best choice for everyone.
                                    Does Hydromet (hydrocodone / homatropine) make you sleepy?
                                    Yes, sleepiness is a common side effect of opioids like the hydrocodone in Hydromet. Let your healthcare team know if you're taking other medications that make you sleepy, such as benzodiazepines or muscle relaxants. Also, avoid alcohol because it can worsen sleepiness (as well as other side effects). Make sure to avoid driving or doing anything that requires concentration until you know how Hydromet (hydrocodone / homatropine) affects you.
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                                    dosage

                                    Hydromet (hydrocodone / homatropine) dosage forms

                                    ml of syrup
                                    Ml of syrup
                                    DosageQuantityPrice as low asPrice per unit
                                    5mg/1.5mg/5ml120 ml$14.67$0.12

                                    Typical dosing for Hydromet (hydrocodone / homatropine)

                                    Hydromet (hydrocodone / homatropine) liquid

                                    Each 5 mL of solution contains 5 mg of hydrocodone and 1.5 mg of homatropine.

                                    Adults: The typical starting dose is 5 mL by mouth every 6 hours as needed. Your primary care provider (PCP) will typically ask you to take the lowest dose for the shortest time needed to manage your cough.

                                    interactions

                                    Interactions between Hydromet (hydrocodone / homatropine) and other drugs

                                    Hydromet (hydrocodone / homatropine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Hydromet (hydrocodone / homatropine). Please note that only the generic name of each medication is listed below.

                                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                    drug-cost

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                                    contraindications-icon

                                    Hydromet (hydrocodone / homatropine) contraindications

                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Hydromet (hydrocodone / homatropine) will not be safe for you to take.
                                    • Children younger than 6 years of age

                                    • Severe asthma or other medical conditions that cause severe, slow breathing

                                    • Medical conditions that cause blockage of the stomach passageway

                                    • Allergy to homatropine

                                    • Allergy to hydrocodone

                                    alternatives

                                    What are alternatives to Hydromet (hydrocodone / homatropine)?

                                    There are a number of medications that your doctor can prescribe in place of Hydromet (hydrocodone / homatropine). Compare a few possible alternatives below.
                                    Hydromet (hydrocodone / homatropine)
                                    Used for:
                                    • Treatment of cough in adults

                                    $11.17 Lowest GoodRx priceView Prices
                                    Used for:
                                    • Cough in people ages 10 years and older

                                    $11.31 Lowest GoodRx priceView Prices
                                    Used for:
                                    • Short-term relief of cough caused by minor throat or lung irritation (e.g., common cold)

                                    $19.07 Lowest GoodRx priceView Prices
                                    images

                                    Hydromet (hydrocodone / homatropine) images

                                    red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5ml Solution
                                    This medicine is Red Syrup.red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5ml Solution
                                    red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution
                                    This medicine is Red Syrup.red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution
                                    red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution
                                    This medicine is Red Syrup.red - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg / 5mL Solution

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                                    References

                                    Best studies we found

                                    Actavis Pharma, Inc. (2024). Hydromet- hydrocodone bitartrate and homatropine methylbromide solution [package insert]. DailyMed.

                                    American College of Obstetricians and Gynecologists. (2017). Opioid use and opioid use disorder in pregnancy.

                                    American College of Obstetricians and Gynecologists. (2021). Breastfeeding challenges: ACOG Committee Opinion, number 820. Obstetrics & Gynecology.

                                    View All References (8)

                                    Centers for Disease Control and Prevention. (2024). About opioid use during pregnancy.

                                    Cofano, S., et al. (2024). Hydrocodone. StatPearls.

                                    Drugs and Lactation Database (LactMed®). (2023). Hydrocodone. National Institute of Child Health and Human Development.

                                    Endocrine Society. (2022). Adrenal insufficiency.

                                    Jansson, L. M., et al. (2019). Neonatal abstinence syndrome. Pediatric Clinics of North America.

                                    Patrick, S. W., et al. (2020). Neonatal opioid withdrawal syndrome. Pediatrics.

                                    PubChem. (n.d.). Homatropine. National Library of Medicine.

                                    Smith, H. S. (2009). Opioid metabolism. Mayo Clinic Proceedings.

                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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