Hycodan is a combination medication that contains hydrocodone (an opioid) and homatropine (an anticholinergic). It's used to help lower the urge to cough in adults. But Hycodan (hydrocodone / homatropine) isn't a first-choice cough medicine because it's a controlled substance and can cause serious side effects, such as trouble breathing. Hycodan (hydrocodone / homatropine) is taken by mouth, typically every 6 hours, as needed. Common side effects include sleepiness, dizziness, and constipation. This medication is available as a generic tablet and an oral solution.
Hycodan (hydrocodone / homatropine) is a combination of two medications:
Hycodan (hydrocodone / homatropine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Hycodan contains an hydrocodone, which is an opioid medication that carries a risk of addiction or misuse, even at recommended doses. In serious cases, addiction and misuse of an opioid medication can lead to overdose and death.
Hycodan (hydrocodone / homatropine) is typically prescribed only when cough relief outweighs these serious risks. If absolutely necessary, your healthcare professional (HCP) will prescribe the lowest amount of medication for the shortest period of time needed to treat your symptoms. Contact your HCP to discuss other options if you've taken Hycodan (hydrocodone / homatropine) for 5 days and your cough hasn't gotten better.
Hycodan (hydrocodone / homatropine) can cause dangerously slow breathing, which can be life-threatening. This can happen at any time, but you're at higher risk 1 to 3 days right after you start Hycodan (hydrocodone / homatropine). Drinking alcohol and taking other medications, like benzodiazepines, can also raise your risk for this dangerous side effect.
You're recommended to ask your prescriber about getting naloxone, a medication that can reverse slowed breathing from opioids. You should have naloxone before you start Hycodan (hydrocodone / homatropine) so that you can use it in case of an accidental overdose. Call 911 to get medical help right away if you or your loved one notices you have trouble breathing or have bluish-colored lips.
Hycodan (hydrocodone / homatropine) can cause extreme sleepiness and lower your ability to think, react, and focus. Your risk for these side effects is higher if you're taking other medications that can make you sleepy, such as benzodiazepines, muscle relaxants, and sleep medications.
Make sure you know how Hycodan (hydrocodone / homatropine) affects you before driving a car or doing activities that require your concentration. Talk to your HCP right away if you feel too sleepy from the medication.
Take Hycodan (hydrocodone / homatropine) exactly as prescribed. Taking too much medication or taking it more often than prescribed can lead to an overdose. When measuring out your dose of Hycodan (hydrocodone / homatropine), only use an oral syringe or a medication cup; don't use household spoons because they might not be accurate. Be sure to keep the opioid medication out of reach from children, pets, or visitors to prevent accidental exposure or overdose. Don't drink alcohol while taking Hycodan (hydrocodone / homatropine) because doing so raises the risk for overdose.
Symptoms of an opioid overdose include not responding to sound or touch, extremely slow breathing, extreme sleepiness, slow heartbeat, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will probably write a prescription for naloxone (Narcan), a medication that can treat an opioid overdose. Carry naloxone with you at all times; use it and call 911 right away if an overdose happens.
Additionally, anticholinergic medications can be found in some over-the-counter products, such as diphenhydramine (Benadryl). Very rarely, taking too much anticholinergic medication can lead to side effects such as confusion, delirium, skin flushing, and fever. To prevent an accidental overdose, read package labels carefully. Ask your pharmacist if you're not sure whether a product has an anticholinergic in it.
Hycodan (hydrocodone / homatropine) interacts with a lot of common medications. So it's important to tell your prescriber and pharmacist about the medications you're taking and planning to take with Hycodan (hydrocodone / homatropine). Your care team can check that your medications are safe to take together. Also talk to your care team first before making any changes to your medications because sudden dose adjustments can also lead to harm.
Some interactions can raise the level of hydrocodone in your body. This can raise your risk for serious side effects, including potentially life-threatening slowed breathing. Examples of medications that can lead to this type of interaction with Hycodan (hydrocodone / homatropine) include erythromycin, ketoconazole, and ritonavir (Norvir).
Other drug interactions can lower the levels of hydrocodone in your body. This can cause the opioid to work less well for you and possibly lead to withdrawal symptoms. These interactions include taking Hycodan (hydrocodone / homatropine) with rifampin (Rifadin) or carbamazepine (Tegretol).
Hycodan (hydrocodone / homatropine) can be transferred to your unborn baby if you take this medication during pregnancy. Long-term opioid use during pregnancy can cause your unborn baby to become dependent on the medication.
Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding and sucking behavior, trembling, irritability, abnormal sleep patterns, and seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your healthcare team know if you've used Hycodan (hydrocodone / homatropine) during pregnancy or if you notice these symptoms in your baby.
Hycodan (hydrocodone / homatropine) can cause extremely low blood pressure. Your blood pressure might drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to your HCP if any dizziness or lightheadedness doesn't go away.
Some people taking opioid medications like Hycodan (hydrocodone / homatropine) have had low adrenal hormone levels. This might be more likely to happen after taking opioids for longer than 1 month. Symptoms include tiredness, dizziness, weakness, not feeling hungry, nausea, and vomiting. Tell your HCP if you have these symptoms. If your adrenal hormone levels are too low, you might need to stop Hycodan (hydrocodone / homatropine) and be treated with corticosteroids.
Opioids such as hydrocodone can raise the risk of having seizures more often in people who have had seizures in the past. Hycodan (hydrocodone / homatropine) can also raise your risk of seizures in certain situations. Get medical help right away if you have a seizure while you're taking this medication.
Hycodan (hydrocodone / homatropine) can cause your gut movement to slow and can lead to constipation or bowel obstruction. This medication shouldn't be taken by people who already have bowel obstruction or conditions related to gut movement. To lower your risk of constipation, drink enough fluids and eat foods that are rich in fiber, such as broccoli, apples, almonds. Get medical attention right away if you experience symptoms related to bowel obstruction, such as serious stomach pains, bloating, or nausea.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Yes. One of the active ingredients in Hycodan is hydrocodone, which is an opioid. The other active ingredient is homatropine, which is an anticholinergic medication.
No, Hycodan (hydrocodone / homatropine) doesn't contain codeine, but it contains hydrocodone. Both codeine and hydrocodone are opioids that work in the brain to lower the urge to cough.
Hycodan (hydrocodone / homatropine) is available as a tablet and an oral solution. Each tablet of Hycodan contains 5 mg of hydrocodone. Each 5 mL of Hycodan solution also contains 5 mg of hydrocodone. Only take this Hycodan as directed by your healthcare team to avoid taking too much medication.
It takes about a day for most of Hycodan (hydrocodone / homatropine) to leave your body after a single dose. This time frame is estimated based on the half-life of the medication. It might differ from person to person based on other factors, such as genetics and whether or not you have kidney problems.
Yes, both medications can be taken together. Ibuprofen (Advil) doesn't have any known interactions with Hycodan (hydrocodone / homatropine). But ibuprofen (Advil)
Is Hycodan (hydrocodone / homatropine) habit-forming?
hydrocodone. Because of this risk, Hycodan (hydrocodone / homatropine) has a black box warning for risk of addiction and dependence and is a schedule II controlled substance, just like other opioids. To lower the risk for addiction and dependence, take Hycodan (hydrocodone / homatropine) exactly as prescribed to you. Your HCP will also prescribe the lowest dose for the shortest period of time needed to treat your condition.
The Hycodan (hydrocodone / homatropine) solution is a clear, red-colored, cherry-flavored liquid. Contact your pharmacist right away if the solution you have appears to be a different color.
Hycodan (hydrocodone / homatropine) is available as a liquid and a tablet.
Each tablet contains 5 mg of hydrocodone and 1.5 mg of homatropine. Each 5 mL of solution also contains 5 mg of hydrocodone and 1.5 mg of homatropine.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Hycodan (hydrocodone / homatropine) will not be safe for you to take.