provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Hydrocodone / Homatropine Coupon - Hydrocodone / Homatropine 5mg/1.5mg tablet

hydrocodone / homatropine

Generic Hycodan
Used for Cough
Used for Cough

Hycodan is a combination medication that contains hydrocodone (an opioid) and homatropine (an anticholinergic). It's used to help lower the urge to cough in adults. But Hycodan (hydrocodone / homatropine) isn't a first-choice cough medicine because it's a controlled substance and can cause serious side effects, such as trouble breathing. Hycodan (hydrocodone / homatropine) is taken by mouth, typically every 6 hours, as needed. Common side effects include sleepiness, dizziness, and constipation. This medication is available as a generic tablet and an oral solution.

Last reviewed on June 20, 2024
Hycodan (hydrocodone / homatropine) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Hycodan (hydrocodone / homatropine)?

What is Hycodan (hydrocodone / homatropine) used for?

  • Treatment of cough in adults

How Hycodan (hydrocodone / homatropine) works

Hycodan (hydrocodone / homatropine) is a combination of two medications:

Are you looking for information on Hydromet (hydrocodone / homatropine) and Norco (hydrocodone / acetaminophen) instead?

Drug Facts

Common BrandsHycodan
Drug ClassOpioid / Anticholinergic
Controlled Substance ClassificationSchedule II
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$55.15(save 71.18%)
GoodRx discount
$15.90
See prices
warings-icon

What are the risks and warnings for Hycodan (hydrocodone / homatropine)?

Hycodan (hydrocodone / homatropine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Potential for misuse and addiction

  • Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health conditions

    Hycodan contains an hydrocodone, which is an opioid medication that carries a risk of addiction or misuse, even at recommended doses. In serious cases, addiction and misuse of an opioid medication can lead to overdose and death.

    Hycodan (hydrocodone / homatropine) is typically prescribed only when cough relief outweighs these serious risks. If absolutely necessary, your healthcare professional (HCP) will prescribe the lowest amount of medication for the shortest period of time needed to treat your symptoms. Contact your HCP to discuss other options if you've taken Hycodan (hydrocodone / homatropine) for 5 days and your cough hasn't gotten better.

    risk-warning

    Dangerously slow breathing (respiratory depression)

    • Risk factors: Older adults | Children younger than 18 years old | Taking medications that can cause slow breathing | Brain injury | Drinking alcohol | Having medical conditions that affect breathing | Taking higher doses of Hycodan (hydrocodone / homatropine) than prescribed

      Hycodan (hydrocodone / homatropine) can cause dangerously slow breathing, which can be life-threatening. This can happen at any time, but you're at higher risk 1 to 3 days right after you start Hycodan (hydrocodone / homatropine). Drinking alcohol and taking other medications, like benzodiazepines, can also raise your risk for this dangerous side effect.

      You're recommended to ask your prescriber about getting naloxone, a medication that can reverse slowed breathing from opioids. You should have naloxone before you start Hycodan (hydrocodone / homatropine) so that you can use it in case of an accidental overdose. Call 911 to get medical help right away if you or your loved one notices you have trouble breathing or have bluish-colored lips.

      risk-warning

      Difficulty concentrating and extreme sleepiness

      • Risk factors: Taking higher doses of Hycodan (hydrocodone / homatropine) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness

        Hycodan (hydrocodone / homatropine) can cause extreme sleepiness and lower your ability to think, react, and focus. Your risk for these side effects is higher if you're taking other medications that can make you sleepy, such as benzodiazepines, muscle relaxants, and sleep medications.

        Make sure you know how Hycodan (hydrocodone / homatropine) affects you before driving a car or doing activities that require your concentration. Talk to your HCP right away if you feel too sleepy from the medication.

        risk-warning

        Risk for overdose

        • Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of Hycodan (hydrocodone / homatropine) | Taking more opioids or antihistamines than prescribed | Drinking alcohol

          Take Hycodan (hydrocodone / homatropine) exactly as prescribed. Taking too much medication or taking it more often than prescribed can lead to an overdose. When measuring out your dose of Hycodan (hydrocodone / homatropine), only use an oral syringe or a medication cup; don't use household spoons because they might not be accurate. Be sure to keep the opioid medication out of reach from children, pets, or visitors to prevent accidental exposure or overdose. Don't drink alcohol while taking Hycodan (hydrocodone / homatropine) because doing so raises the risk for overdose.

          Symptoms of an opioid overdose include not responding to sound or touch, extremely slow breathing, extreme sleepiness, slow heartbeat, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will probably write a prescription for naloxone (Narcan), a medication that can treat an opioid overdose. Carry naloxone with you at all times; use it and call 911 right away if an overdose happens.

          Additionally, anticholinergic medications can be found in some over-the-counter products, such as diphenhydramine (Benadryl). Very rarely, taking too much anticholinergic medication can lead to side effects such as confusion, delirium, skin flushing, and fever. To prevent an accidental overdose, read package labels carefully. Ask your pharmacist if you're not sure whether a product has an anticholinergic in it.

          risk-warning

          Drug interactions

          Hycodan (hydrocodone / homatropine) interacts with a lot of common medications. So it's important to tell your prescriber and pharmacist about the medications you're taking and planning to take with Hycodan (hydrocodone / homatropine). Your care team can check that your medications are safe to take together. Also talk to your care team first before making any changes to your medications because sudden dose adjustments can also lead to harm.

          Some interactions can raise the level of hydrocodone in your body. This can raise your risk for serious side effects, including potentially life-threatening slowed breathing. Examples of medications that can lead to this type of interaction with Hycodan (hydrocodone / homatropine) include erythromycin, ketoconazole, and ritonavir (Norvir).

          Other drug interactions can lower the levels of hydrocodone in your body. This can cause the opioid to work less well for you and possibly lead to withdrawal symptoms. These interactions include taking Hycodan (hydrocodone / homatropine) with rifampin (Rifadin) or carbamazepine (Tegretol).

          risk-warning

          Harm to newborn babies

          Hycodan (hydrocodone / homatropine) can be transferred to your unborn baby if you take this medication during pregnancy. Long-term opioid use during pregnancy can cause your unborn baby to become dependent on the medication.

          Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding and sucking behavior, trembling, irritability, abnormal sleep patterns, and seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your healthcare team know if you've used Hycodan (hydrocodone / homatropine) during pregnancy or if you notice these symptoms in your baby.

          risk-warning

          Low blood pressure

          Hycodan (hydrocodone / homatropine) can cause extremely low blood pressure. Your blood pressure might drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to your HCP if any dizziness or lightheadedness doesn't go away.

          risk-warning

          Low adrenal hormone levels

          • Risk factors: Taking Hycodan (hydrocodone / homatropine) for longer than 1 month

            Some people taking opioid medications like Hycodan (hydrocodone / homatropine) have had low adrenal hormone levels. This might be more likely to happen after taking opioids for longer than 1 month. Symptoms include tiredness, dizziness, weakness, not feeling hungry, nausea, and vomiting. Tell your HCP if you have these symptoms. If your adrenal hormone levels are too low, you might need to stop Hycodan (hydrocodone / homatropine) and be treated with corticosteroids.

            risk-warning

            Seizures

            • Risk factors: History of seizure conditions

              Opioids such as hydrocodone can raise the risk of having seizures more often in people who have had seizures in the past. Hycodan (hydrocodone / homatropine) can also raise your risk of seizures in certain situations. Get medical help right away if you have a seizure while you're taking this medication.

              risk-warning

              Caution in people with gut-related conditions

              Hycodan (hydrocodone / homatropine) can cause your gut movement to slow and can lead to constipation or bowel obstruction. This medication shouldn't be taken by people who already have bowel obstruction or conditions related to gut movement. To lower your risk of constipation, drink enough fluids and eat foods that are rich in fiber, such as broccoli, apples, almonds. Get medical attention right away if you experience symptoms related to bowel obstruction, such as serious stomach pains, bloating, or nausea.

              basics-icon

              What are the side effects of Hycodan (hydrocodone / homatropine)?

              The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

              Common Side Effects

              • Sleepiness
              • Trouble thinking clearly
              • Trouble walking or performing tasks
              • Lightheadedness
              • Dizziness
              • Headache
              • Dry mouth
              • Nausea
              • Vomiting
              • Constipation

              Other Side Effects

              • Flushing
              • Itching
              • Rash
              • Stomach pain
              • Low appetite

              Serious Side Effects

              Contact your healthcare provider immediately if you experience any of the following.
              • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
              • Accidentally taking too much (overdose): not responding to sound or touch, slow breathing, extreme sleepiness, cold or clammy skin, slow or irregular heartbeat, confusion, seizure
              • Opioid withdrawal (if suddenly stopped after long-term use): anxiety, suicidal thoughts, restlessness, runny nose, yawning, sweating, chills, wide pupils, irritability
              • Excessive sleepiness or dizziness
              • Seizures

              Source: DailyMed

              The following side effects have also been reported

              Side effects that you should report to your care team as soon as possible:

              • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
              • CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
              • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
              • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision

              Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

              pros-and-cons

              Pros and cons of Hycodan (hydrocodone / homatropine)

              thumbs-up

              Pros

              Available as a tablet and as a liquid

              Can be used as needed for cough

              Available as a lower-cost generic

              thumbs-down

              Cons

              Hasn't been studied in children

              Can be habit-forming

              Only provides relief for the cough, but doesn't help the actual cause of the cough

              pharmacist-tips

              Pharmacist tips for Hycodan (hydrocodone / homatropine)

              pharmacist
              • Take Hycodan (hydrocodone / homatropine) with or without food. If it's hurting your stomach, taking it with food might help.

                • Let your prescriber know if your cough doesn't get better after taking Hycodan (hydrocodone / homatropine) for 5 days. You might need to receive different treatment. Taking Hycodan (hydrocodone / homatropine) when it doesn't work well to treat a cough raises your risk for dependence and serious side effects, such as sleepiness and breathing problems.

                  • Hycodan (hydrocodone / homatropine) can make you sleepy and dizzy, which can affect your ability to think, react, and focus. Don't drive or do activities where you need to focus until you know how this medication affects you.

                    • You shouldn't drink alcohol while you're taking Hycodan (hydrocodone / homatropine). Doing so can make you very sleepy or dizzy and make it hard to think clearly. This can lead to accidental injuries.

                      • Tell your prescriber and pharmacist about all the medications you're taking to make sure Hycodan (hydrocodone / homatropine) is safe to take with them. Your care team should review your medication list to make sure your medications are safe to take together. Several medications can interact with Hycodan (hydrocodone / homatropine), which can be harmful.

                        • Talk with your prescriber if you've been regularly taking Hycodan (hydrocodone / homatropine) for a long period of time and you want to stop. Your prescriber might lower your dose slowly over time before you can stop completely. This helps prevent opioid withdrawal symptoms, such as anxiety, sweating, chills, and irritability, which can happen after lowering your dose or stopping the medication too suddenly.

                          • Tell your healthcare team if you're breastfeeding. It's typically recommended to avoid Hycodan (hydrocodone / homatropine) because hydrocodone can get into breast milk. This raises the risk for serious side effects to your baby (e.g., sleepiness, slowed breathing).

                            • Store the Hycodan (hydrocodone / homatropine) liquid at room temperature. Only use the plastic dosing spoon, medication dosing cup, or oral syringe that the pharmacy gives you to measure out your dose. Never use household spoons because they aren't accurate.

                              • Store Hycodan (hydrocodone / homatropine) out of reach from children, pets, or visitors. Contact a pharmacist about how to get rid of it safely if you don't need to take the medication anymore. This lowers the risk of accidental overdose and helps prevent medication misuse.

                                faqs

                                Frequently asked questions about Hycodan (hydrocodone / homatropine)

                                Is Hycodan (hydrocodone / homatropine) an opioid?
                                Yes. One of the active ingredients in Hycodan is hydrocodone, which is an opioid. The other active ingredient is homatropine, which is an anticholinergic medication.
                                Does Hycodan (hydrocodone / homatropine) have codeine in it?
                                No, Hycodan (hydrocodone / homatropine) doesn't contain codeine, but it contains hydrocodone. Both codeine and hydrocodone are opioids that work in the brain to lower the urge to cough.
                                How much hydrocodone is in Hycodan (hydrocodone / homatropine)?
                                Hycodan (hydrocodone / homatropine) is available as a tablet and an oral solution. Each tablet of Hycodan contains 5 mg of hydrocodone. Each 5 mL of Hycodan solution also contains 5 mg of hydrocodone. Only take this Hycodan as directed by your healthcare team to avoid taking too much medication.
                                How long does Hycodan (hydrocodone / homatropine) stay in your system?
                                It takes about a day for most of Hycodan (hydrocodone / homatropine) to leave your body after a single dose. This time frame is estimated based on the half-life of the medication. It might differ from person to person based on other factors, such as genetics and whether or not you have kidney problems.
                                Can you take ibuprofen with Hycodan (hydrocodone / homatropine)?
                                Yes, both medications can be taken together. Ibuprofen (Advil) doesn't have any known interactions with Hycodan (hydrocodone / homatropine). But ibuprofen (Advil)
                                has several risks too, so it's not the best choice for everyone. People with certain medical conditions should ask a healthcare provider first if it's safe to take ibuprofen (Advil) with Hycodan (hydrocodone / homatropine), such as those with heart failure or kidney problems.
                                Is Hycodan (hydrocodone / homatropine) habit-forming?
                                Yes. Hycodan has a risk of being habit-forming because it contains the opioid
                                hydrocodone. Because of this risk, Hycodan (hydrocodone / homatropine) has a black box warning for risk of addiction and dependence and is a schedule II controlled substance, just like other opioids. To lower the risk for addiction and dependence, take Hycodan (hydrocodone / homatropine) exactly as prescribed to you. Your HCP will also prescribe the lowest dose for the shortest period of time needed to treat your condition.
                                What color is Hycodan (hydrocodone / homatropine) syrup?
                                The Hycodan (hydrocodone / homatropine) solution is a clear, red-colored, cherry-flavored liquid. Contact your pharmacist right away if the solution you have appears to be a different color.
                                GoodRxEducationalIcon

                                How to save using GoodRx

                                Compare Prices
                                1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                                Select your free coupon
                                2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                                Show coupon to your pharmacist
                                3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                                Get free couponLearn more
                                dosage

                                Hycodan (hydrocodone / homatropine) dosage forms

                                The average cost for 30 tablets of 5mg/1.5mg of Hycodan (hydrocodone / homatropine) is $57.54 with a free GoodRx coupon. This is -20.6% off the average retail price of $47.71.
                                ml of syrup
                                Ml of syrup
                                DosageQuantityPrice as low asPrice per unit
                                5mg/1.5mg/5ml120 ml$15.90$0.13
                                tablet
                                Tablet
                                DosageQuantityPrice as low asPrice per unit
                                5mg/1.5mg45 tablets$57.54$1.28

                                Typical dosing for Hycodan (hydrocodone / homatropine)

                                Hycodan (hydrocodone / homatropine) is available as a liquid and a tablet.

                                Each tablet contains 5 mg of hydrocodone and 1.5 mg of homatropine.
                                Each 5 mL of solution also contains 5 mg of hydrocodone and 1.5 mg of homatropine.

                                • Adults: The typical starting dose is 1 tablet (or 5 mL of oral solution) by mouth every 6 hours as needed. Your primary care provider (PCP) will typically ask you to take the lowest dose for the shortest time needed to manage your cough.

                                drug-cost

                                How much does Hycodan (hydrocodone / homatropine) cost?

                                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                                contraindications-icon

                                Hycodan (hydrocodone / homatropine) contraindications

                                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Hycodan (hydrocodone / homatropine) will not be safe for you to take.
                                • Children younger than 6 years of age

                                • Severe asthma or other medical conditions that cause severe, slow breathing

                                • Medical conditions that cause blockage of the stomach passageway

                                • Allergy to homatropine

                                • Allergy to hydrocodone

                                alternatives

                                What are alternatives to Hycodan (hydrocodone / homatropine)?

                                There are a number of medications that your doctor can prescribe in place of Hycodan (hydrocodone / homatropine). Compare a few possible alternatives below.
                                Hycodan (hydrocodone / homatropine)
                                Used for:
                                • Treatment of cough in adults

                                $15.90 Lowest GoodRx priceView Prices
                                Used for:
                                • Minor irritation in the mouth

                                • Sore throat or mouth

                                • Cough

                                Used for:
                                • Cough in people ages 10 years and older

                                $11.31 Lowest GoodRx priceView Prices
                                images

                                Hycodan (hydrocodone / homatropine) images

                                White Round N 350 - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg Tablet
                                This medicine is White, Round, Scored Tablet Imprinted With "N 350".White Round N 350 - Hydrocodone Bitartrate / Homatropine Methylbromide 5mg-1.5mg Tablet

                                Get savings updates for Hycodan (hydrocodone / homatropine)

                                Receive price alerts, news, and other messages from GoodRx about Hycodan (hydrocodone / homatropine) and other healthcare topics and relevant savings offers.

                                By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                                References

                                Best studies we found

                                Actavis Pharma, Inc. (2024). Hydromet- hydrocodone bitartrate and homatropine methylbromide solution [package insert]. DailyMed.

                                American College of Obstetricians and Gynecologists. (2017). Opioid use and opioid use disorder in pregnancy.

                                Centers for Disease Control and Prevention. (2024). About opioid use during pregnancy.

                                View All References (10)

                                Cofano, S., et al. (2024). Hydrocodone. StatPearls.

                                Drugs and Lactation Database (LactMed®). (2023). Hydrocodone. National Institute of Child Health and Human Development.

                                Endocrine Society. (2022). Adrenal insufficiency.

                                Genus Lifesciences Inc. (2021). Hycodan- hydrocodone bitartrate and homatropine methylbromide tablet; Hycodan- hydrocodone bitartrate and homatropine methylbromide solution [package insert]. DailyMed. 

                                Jansson, L. M., et al. (2019). Neonatal abstinence syndrome. Pediatric Clinics of North America.

                                National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms and causes of adrenal insufficiency & Addison’s disease.

                                Obstetrics and Gynecology. (2021). Breastfeeding challenges: ACOG Committee Opinion, Number 820.

                                Patrick, S. W., et al. (2020). Neonatal opioid withdrawal syndrome. Pediatrics.

                                PubChem. (n.d.). Homatropine. National Library of Medicine.

                                Smith, H. S. (2009). Opioid metabolism. Mayo Clinic Proceedings.

                                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                                Was this page helpful?

                                Compare other Cough drugs

                                Browse medications

                                View All

                                Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.