Key takeaways
Hydromet (hydrocodone/homatropine) and Guaifenesin AC (codeine/guaifenesin) are both prescription medications used to treat cough, but they have some key differences. Hydromet combines an opioid (hydrocodone) with an anticholinergic (homatropine) and is typically taken every 6 hours as needed. It works by reducing the urge to cough and is available as a generic. However, it can cause serious side effects like trouble breathing and is habit-forming. On the other hand, Guaifenesin AC combines an opioid (codeine) with an expectorant (guaifenesin) and is taken every 4 hours as needed. It helps loosen mucus and calm coughs, but it is also habit-forming and not recommended for long-term use. Guaifenesin AC is a Schedule V controlled substance, which is less restrictive than Hydromet's Schedule II classification. Both medications can cause drowsiness and should be used with caution, especially when combined with other substances like alcohol.
