Expectorant / opioid combinations are used to relieve cough and chest congestion. They work by combining an expectorant, which helps to thin and loosen mucus in your airways, with an opioid, which helps to reduce the urge to cough. These medications are usually available as oral syrups. Examples include guaifenesin / codeine (Cheratussin AC, Virtussin AC) and hydrocodone / guaifenesin (Obredon). You can discuss with your healthcare team which option might be right for you.