The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Metastatic prostate cancer:
- Rash (28%)
- Hot flashes (23%)
- High blood pressure (18%)
- Join pain (17%)
- Itchiness (11%)
Non-metastatic prostate cancer:
- Tiredness (39%)
- Rash (25%)
- High blood pressure (25%)
- Diarrhea (20%)
- Nausea (18%)
- Joint pain (16%)
- Weight loss (16%)
- Fall (16%)
- Hot flashes (14%)
- Fracture (12%)
- Reduced appetite (12%)
- Swelling in arms and legs (11%)
Less Common Side Effects
Metastatic prostate cancer:
- Diarrhea
- Muscle spasm
- Changes in taste
- Low thyroid hormone levels
- Lung problems
Non-metastatic prostate cancer:
- Low thyroid hormone levels
- Itchiness
- Heart failure
- Lung problems
Erleada serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Heart problems: chest pain, shortness of breath, rapid breathing, sweating, fatigue, dizziness, nausea, vomiting
- Stroke: sudden numbness or weakness, confusion, trouble talking, trouble seeing, dizziness, trouble walking
- Fractures: pain, swelling, bruising, tenderness, bleeding, numbness
- Seizures: sudden jerking or shaking, loss of consciousness, confusion, trouble speaking
- Severe skin reactions: rash, fever, swollen lymph nodes, blisters or sores, blistering or peeling skin
- Lung problems: shortness of breath, cough, fever
Source: DailyMed
The following Erleada side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry cough, shortness of breath or trouble breathing
- Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
- Increase in blood pressure
- Rash, fever, and swollen lymph nodes
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Seizures
- Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Fatigue
- Hot flashes
- Joint pain
- Loss of appetite



