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Adapalene / Benzoyl Peroxide Coupon - Adapalene / Benzoyl Peroxide 45g of 0.1%/2.5% gel pump

adapalene / benzoyl peroxide

Generic Epiduo
Used for Acne
Used for Acne

Epiduo (adapalene / benzoyl peroxide) is a topical gel that contains two active ingredients: adapalene (a retinoid) and benzoyl peroxide (an antiseptic). It's FDA approved to treat acne (pimples) in adults and children. The gel is typically applied to the skin once a day. Side effects aren't common, but can include dry skin, skin irritation, and skin burning. The medication is available as a generic and under two brand names: Epiduo and Epiduo Forte.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on August 14, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Epiduo (adapalene / benzoyl peroxide)?

What is Epiduo (adapalene / benzoyl peroxide) used for?

  • Acne in

    • People 9 years and older - Epiduo

    • People 12 years and older - Epiduo Forte

How Epiduo (adapalene / benzoyl peroxide) works

Epiduo (adapalene / benzoyl peroxide) is a retinoid / antiseptic combination of two medications that help treat acne.

  • Adapalene is a retinoid, which is a form of vitamin A. It helps prevent clogged pores by removing dead skin cells and replacing them with new ones.

  • Benzoyl peroxide is an antiseptic. It works by killing the bacteria on the skin that causes acne.

Are you looking for information on benzoyl peroxide topical products or adapalene (Differin) instead?
When does Epiduo (adapalene / benzoyl peroxide) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsEpiduo, Epiduo Forte
Drug ClassRetinoid / Topical antibiotic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$312.530
GoodRx discount
$312.53
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basics-icon

What are the side effects of Epiduo (adapalene / benzoyl peroxide)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Epiduo:
  • Dry skin (7%)
  • Rash (3%)
Epiduo Forte:
  • Skin irritation (4%)

Other Side Effects

  • Skin burning
  • Skin scaling
  • Skin redness
When do Epiduo (adapalene / benzoyl peroxide) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Dry skin
Burning
Skin irritation
Skin redness

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Change in skin color
  • Mild skin irritation, redness, or dryness
  • Sensitivity to light
pros-and-cons

Pros and cons of Epiduo (adapalene / benzoyl peroxide)

thumbs-up

Pros

Combination of two medications in a single product

Only needs to be applied once a day

Easy to apply

Available as a lower-cost generic

thumbs-down

Cons

Can make your skin more sensitive to the sunlight

Can bleach clothing and bed sheets

Can make skin dry or irritated

Your skin might look worse before it starts looking better

pharmacist-tips

Pharmacist tips for Epiduo (adapalene / benzoyl peroxide)

pharmacist

  • Use a mild cleanser to clean the affected area(s) where you'll be applying Epiduo (adapalene / benzoyl peroxide). Make sure your skin is completely dry before using Epiduo (adapalene / benzoyl peroxide).

    • Apply a thin layer of Epiduo (adapalene / benzoyl peroxide) once per day on the affected area(s) of the skin. Avoid applying the gel to skin with eczema, sunburns, cuts, or scrapes.

      • Epiduo (adapalene / benzoyl peroxide) should be applied directly on your skin only. Don't apply the medication in your eyes, mouth, or nose since that could lead to side effects.

        • Use a mild moisturizer as often as needed to help prevent your skin from becoming too dry or irritated from Epiduo (adapalene / benzoyl peroxide).

          • Use sunscreen and wear protective clothing (e.g., hats, long-sleeved shirts) when going outside because Epiduo (adapalene / benzoyl peroxide) can make your skin more sensitive to sunlight.

            • After applying Epiduo (adapalene / benzoyl peroxide), it's possible to feel or see skin redness, dryness, peeling, or stinging, especially during the first month. This is how the medication works and is normal, but it should go away as you continue to use it. If these skin reactions become too bothersome, talk to your care team.

              • Don't use medicated soaps, cleansers, shampoos, or other personal care products that might cause skin irritation when using Epiduo (adapalene / benzoyl peroxide). Some products contain drying agents, like alcohol, which can further irritate the skin. Ask your pharmacist or dermatologist for guidance on which products are safe to use with this medication.

                • Epiduo (adapalene / benzoyl peroxide) can bleach your hair, colored fabric, and bed sheets. After applying the medication, make sure you let it completely dry before dressing, changing clothes, or lying down in bed.

                  • Avoid waxing for hair removal on areas of your skin treated with Epiduo (adapalene / benzoyl peroxide), as this can cause further skin irritation.

                    • Store Epiduo (adapalene / benzoyl peroxide) at room temperature away from heat. Keep it tightly closed and out of reach from children.

                      faqs

                      Frequently asked questions about Epiduo (adapalene / benzoyl peroxide)

                      What happens when you stop using Epiduo (adapalene / benzoyl peroxide)?
                      Stopping Epiduo (adapalene / benzoyl peroxide) can cause your acne to come back. To make sure you're getting the most out of your treatment, use the medication as prescribed. If you're thinking about stopping Epiduo (adapalene / benzoyl peroxide) but are worried about your acne returning, talk to your care team. They can suggest lifestyle changes, like a consistent skincare routine, a balanced diet, and regular exercise, to help manage your skin.
                      Is Epiduo (adapalene / benzoyl peroxide) a retinol?
                      Epiduo (adapalene / benzoyl peroxide) contains adapalene and benzoyl peroxide. While the adapalene component isn’t exactly a retinol, it's similar. Both retinol and adapalene are types of retinoids, which are forms of vitamin A. Retinol is a retinoid you can buy over-the-counter and is often used in skincare products. On the other hand, the adapalene in Epiduo (adapalene / benzoyl peroxide) is a stronger, prescription-only retinoid used to treat acne.
                      Can I use Epiduo (adapalene / benzoyl peroxide) in the morning?
                      Yes, Epiduo (adapalene / benzoyl peroxide) can be used at any time of the day, including the morning. The most important thing is to be consistent and use it at the same time each day for the medication to work best.
                      Can I use Epiduo (adapalene / benzoyl peroxide) twice a day?
                      Epiduo (adapalene / benzoyl peroxide) should only be applied once per day unless your prescriber specifically said it was okay to apply it more frequently. Applying this medication more than once per day won't make it work any better; instead, it'll raise your risk for side effects like skin irritation, stinging, and burning. Talk to your prescriber if you have questions on how often you should use Epiduo (adapalene / benzoyl peroxide).
                      Can I use Epiduo (adapalene / benzoyl peroxide) while pregnant?
                      There isn't much research on the safety of Epiduo (adapalene / benzoyl peroxide) during pregnancy. In general, oral retinoids should be avoided during pregnancy because it can cause serious harm to the unborn baby. But research is less clear about topical retinoids like Epiduo (adapalene / benzoyl peroxide). Discuss with your dermatologist before using this medication if you're pregnant or thinking of becoming pregnant.
                      Can I use Epiduo (adapalene / benzoyl peroxide) with hyaluronic acid?
                      Probably, moisturizers containing hyaluronic acid can be used with Epiduo (adapalene / benzoyl peroxide). Moisturizers are useful especially if Epiduo (adapalene / benzoyl peroxide) is drying out your skin. But speak with your dermatologist if you have questions about what products you can use with Epiduo (adapalene / benzoyl peroxide).
                      Can Epiduo (adapalene / benzoyl peroxide) be used as a spot treatment?
                      Epiduo (adapalene / benzoyl peroxide) isn't typically used as a spot treatment for acne, nor was it studied that way. It's meant to be applied across the entire affected area of your face and/or trunk. Ask your dermatologist if you have questions on the best product to use for spot treatment.
                      What's the difference between Epiduo and Epiduo Forte?
                      Epiduo and Epiduo Forte are brand-name medications containing adapalene / benzoyl peroxide. The main difference is the strength of adapalene they contain. Epiduo has a lower strength with adapalene 0.1% and benzoyl peroxide 2.5%, and it's approved for people 9 years and older. Epiduo Forte has a higher strength with adapalene 0.3% and benzoyl peroxide 2.5%, and it's approved for people 12 years and older. Talk to your dermatologist to find out which option is best for you.
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                      What are the risks and warnings for Epiduo (adapalene / benzoyl peroxide)?

                      Epiduo (adapalene / benzoyl peroxide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                      risk-warning

                      Sunburn

                      Your skin can become more sensitive to sunlight while using Epiduo (adapalene / benzoyl peroxide). Too much exposure to the sun can cause severe sunburn. Minimize your exposure to sunlight, sun lamps, and tanning beds during and immediately following treatment with Epiduo (adapalene / benzoyl peroxide). If possible, limit your time out in the sun or seek shade when you're outside. If you plan on spending time in the sun, wear sunscreen and protective clothing (e.g., hats, long-sleeved shirts).

                      risk-warning

                      Skin irritation

                      • Risk factors: First month of using Epiduo (adapalene / benzoyl peroxide) | Applying Epiduo (adapalene / benzoyl peroxide) to areas with cuts, wounds, or bruises | Also using medicated skin products

                        Epiduo (adapalene / benzoyl peroxide) can cause skin irritation, such as dry skin, redness, and stinging or burning. These skin reactions are expected to be worse during the first month of using the medication, and should get better after that. Use a mild, non-medicated moisturizer as much as needed to help prevent skin irritation. Don't apply Epiduo (adapalene / benzoyl peroxide) to areas of your skin with cuts, scrapes, wounds, or bruises, because those areas might already be irritated. Also, avoid hair waxing on skin areas treated with the medication because this can lead to worsening skin damage. Depending on how severe your side effects are, your prescriber might recommend you use Epiduo (adapalene / benzoyl peroxide) less often or even stop the medication altogether.

                        dosage

                        Epiduo (adapalene / benzoyl peroxide) dosage forms

                        The average cost for 1 pump of 45g of 0.1%/2.5% of Epiduo (adapalene / benzoyl peroxide) is $416.35 with a free GoodRx coupon. This is 18.93% off the average retail price of $513.57.
                        gel pump
                        Gel pump
                        DosageQuantityPrice as low asPrice per unit
                        45g of 0.1%/2.5%1 pump$416.35$416.35

                        Typical dosing for Epiduo (adapalene / benzoyl peroxide)

                        Apply a thin layer to the affected area of skin once a day.

                        drug-cost

                        How much does Epiduo (adapalene / benzoyl peroxide) cost?

                        To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                        Epiduo (brand)
                        GoodRx lowest price

                        $416.35

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                        Epiduo (adapalene / benzoyl peroxide) (generic)
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                        $312.53

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                        contraindications-icon

                        Epiduo (adapalene / benzoyl peroxide) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Epiduo (adapalene / benzoyl peroxide) will not be safe for you to take.

                        • Allergy to adapalene or benzoyl peroxide

                        alternatives

                        What are alternatives to Epiduo (adapalene / benzoyl peroxide)?

                        There are a number of medications that your doctor can prescribe in place of Epiduo (adapalene / benzoyl peroxide). Compare a few possible alternatives below.
                        Epiduo (adapalene / benzoyl peroxide)
                        Used for:

                        • Acne in

                          • People 9 years and older - Epiduo

                          • People 12 years and older - Epiduo Forte

                        $312.53 Lowest GoodRx priceView Prices
                        Benzamycin (erythromycin / benzoyl peroxide)
                        Used for:

                        • Acne

                        $31.87 Lowest GoodRx priceView Prices
                        Clindamycin/benzoyl peroxide
                        Used for:
                        $36.00 Lowest GoodRx priceView Prices
                        images

                        Epiduo (adapalene / benzoyl peroxide) images

                        yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel
                        This medicine is Yellow Gel Pump.yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel
                        white and yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel
                        This medicine is White And Yellow Gel Pump.white and yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel
                        yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel
                        This medicine is Yellow Gel Pump.yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel
                        yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel
                        This medicine is Yellow Gel Pump.yellow - Adapalene / Benzoyl Peroxide Pump 0.1%-2.5% Topical Gel

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                        References

                        Best studies we found

                        Alembic Pharmaceuticals Inc. (2023). Adapalene and benzoyl peroxide- adapalene and benzoyl peroxide topical gel [package insert]. DailyMed.

                        Matin, T., et al. (2024). Benzoyl peroxide. StatPearls.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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