What is Enulose?

Oral laxatives are medicines taken by mouth to encourage bowel movements to relieve constipation.

There are several different types of oral laxatives and they work in different ways. Since directions for use are different for each type, it is important to know which one you are taking. The different types of oral laxatives include:

Bulk-formers—Bulk-forming laxatives are not digested but absorb liquid in the intestines and swell to form a soft, bulky stool. The bowel is then stimulated normally by the presence of the bulky mass. Some bulk-forming laxatives, like psyllium and polycarbophil, may be prescribed by your doctor to treat diarrhea.

Hyperosmotics—Hyperosmotic laxatives encourage bowel movements by drawing water into the bowel from surrounding body tissues. This provides a soft stool mass and increased bowel action.

There are three types of hyperosmotic laxatives taken by mouth—the saline, the lactulose , and the polymer types:

• The saline type is often called "salts." They are used for rapid emptying of the lower intestine and bowel. They are not used for long-term or repeated correction of constipation. With smaller doses than those used for the laxative effect, some saline laxatives are used as antacids. The information that follows applies only to their use as laxatives. Sodium phosphate may also be prescribed for other conditions as determined by your doctor.
• The lactulose type is a special sugar-like laxative that works the same way as the saline type. However, it produces results much more slowly and is often used for long-term treatment of chronic constipation. Lactulose may sometimes be used in the treatment of certain medical conditions to reduce the amount of ammonia in the blood. It is available only with your doctor's prescription.
• The polymer type is a polyglycol (polyethylene glycol), a large molecule that causes water to be retained in the stool; this will soften the stool and increase the number of bowel movements. It is used for short periods of time to treat constipation.

Lubricants—Lubricant laxatives, such as mineral oil, taken by mouth encourage bowel movements by coating the bowel and the stool mass with a waterproof film. This keeps moisture in the stool. The stool remains soft and its passage is made easier.

Stimulants—Stimulant laxatives, also known as contact laxatives, encourage bowel movements by acting on the intestinal wall. They increase the muscle contractions that move along the stool mass. Stimulant laxatives are a popular type of laxative for self-treatment. However, they also are more likely to cause side effects. One of the stimulant laxatives, dehydrocholic acid, may also be used for treating certain conditions of the biliary tract.

Stool softeners (emollients)—Stool softeners encourage bowel movements by helping liquids mix into the stool and prevent dry, hard stool masses. This type of laxative has been said not to cause a bowel movement but instead allows the patient to have a bowel movement without straining.

Combinations—There are many products that you can buy for constipation that contain more than one type of laxative. For example, a product may contain both a stool softener and a stimulant laxative. In general, combination products may be more likely to cause side effects because of the multiple ingredients. In addition, they may not offer any advantage over products containing only one type of laxative. If you are taking a combination laxative, make certain you know the proper use and precautions for each of the different ingredients.

Most laxatives (except saline laxatives) may be used to provide relief:

• during pregnancy.
• for a few days after giving birth.
• during preparation for examination or surgery.
• for constipation of bedfast patients.
• for constipation caused by other medicines.
• following surgery when straining should be avoided.
• following a period of poor eating habits or a lack of physical exercise in order to develop normal bowel function (bulk-forming laxatives only).
• for some medical conditions that may be made worse by straining, for example:
  • Heart disease
  • Hemorrhoids
  • Hernia (rupture)
  • High blood pressure (hypertension)
  • History of stroke

Saline laxatives have more limited uses and may be used to provide rapid results:

• during preparation for examination or surgery.
• for elimination of food or drugs from the body in cases of poisoning or overdose.
• for simple constipation that happens on occasion (although another type of laxative may be preferred).
• in supplying a fresh stool sample for diagnosis.

Laxatives are available both over-the-counter (OTC) and with your doctor's prescription.

For safe and effective use of your laxative:

• Follow your doctor's instructions if this laxative was prescribed.
• Follow the manufacturer's package directions if you are treating yourself.

With all kinds of laxatives, at least 6 to 8 glasses (8 ounces each) of liquids should be taken each day. This will help make the stool softer.

For patients taking laxatives containing a bulk-forming ingredient:

• Do not try to swallow in the dry form. Mix with liquid following the directions on the product label.
• To allow bulk-forming laxatives to work properly and to prevent intestinal blockage, it is necessary to drink plenty of fluids during their use. Each dose should be taken in or with a full glass (8 ounces) or more of cold water or fruit juice. This will provide enough liquid for the laxative to work properly. A second glass of water or juice by itself is often recommended with each dose for best effect and to avoid side effects.
• When taking a product that contains only a bulk-forming ingredient, results often may be obtained in 12 hours. However, this may not occur for some individuals until after 2 or 3 days.

For patients taking laxatives containing a stool softener (emollient):

• Liquid forms may be taken in milk or fruit juice to improve flavor.
• When taking a product that contains only a stool softener, results usually occur 1 to 2 days after the first dose. However, this may not occur for some individuals until after 3 to 5 days.

For patients taking laxatives containing a hyperosmotic ingredient:

• Each dose should be taken in or with a full glass (8 ounces) or more of cold water or fruit juice. This will provide enough liquid for the laxative to work properly. A second glass of water or juice by itself is often recommended with each dose for best effect and, in the case of saline laxatives, to prevent you from becoming dehydrated.
• The unpleasant taste produced by some hyperosmotic laxatives may be improved by following each dose with citrus fruit juice or citrus-flavored carbonated beverage.
• Lactulose may not produce laxative results for 24 to 48 hours.
• Polyethylene glycol may not produce laxative results for 2 to 4 days.
• Saline laxatives usually produce results within 30 minutes to 3 hours following a dose. When a larger dose is taken on an empty stomach, the results are quicker. When a smaller dose is taken with food, the results are delayed. Therefore, large doses of saline laxatives are usually not taken late in the day on an empty stomach.

For patients taking laxatives containing mineral oil:

• Mineral oil should not be taken within 2 hours of meals because of possible interference with food digestion and absorption of nutrients and vitamins.
• Mineral oil is usually taken at bedtime (but not while lying down) for convenience and because it requires about 6 to 8 hours to produce results.

For patients taking laxatives containing a stimulant ingredient:

• Stimulant laxatives are usually taken on an empty stomach for rapid effect. Results are slowed if taken with food.
• Many stimulant laxatives (but not castor oil) are often taken at bedtime to produce results the next morning (although some may require 24 hours or more).
• Castor oil is not usually taken late in the day because its results occur within 2 to 6 hours.
• The unpleasant taste of castor oil may be improved by chilling in the refrigerator for at least an hour and then stirring the dose into a full glass of cold orange juice just before it is taken. Also, flavored preparations of castor oil are available.
• Bisacodyl tablets are specially coated to allow them to work properly without causing irritation and/or nausea. To protect this coating, do not chew, crush, or take the tablets within an hour of milk or antacids.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Laxatives should not be given to young children (up to 6 years of age) unless prescribed by their doctor. Since children usually cannot describe their symptoms very well, they should be checked by a doctor before being given a laxative. The child may have a condition that needs other treatment. If so, laxatives will not help, and may even cause unwanted effects or make the condition worse.

Mineral oil should not be given to young children (up to 6 years of age) because a form of pneumonia may be caused by the inhalation of oil droplets into the lungs.

Also, bisacodyl tablets should not be given to children up to 6 years of age because if chewed they may cause stomach irritation.

Mineral oil should not be taken by bedridden elderly persons because a form of pneumonia may be caused by the inhalation of oil droplets into the lungs. Also, stimulant laxatives (e.g., bisacodyl or casanthranol), if taken too often, may worsen weakness, lack of coordination, or dizziness and light-headedness.

Polyethylene glycol 3350 should be discontinued if diarrhea occurs, especially in elderly persons in nursing homes.

Although laxatives are often used during pregnancy, some types are better than others. Stool softeners (emollient) laxatives and bulk-forming laxatives are probably used most often. If you are using a laxative during pregnancy, remember that:

• Some laxatives (in particular, the bulk-formers) contain a large amount of sodium or sugars, which may have possible unwanted effects such as increasing blood pressure or causing water to be held in the body.
• Saline laxatives containing magnesium, potassium, or phosphates may have to be avoided if your kidney function is not normal.
• Mineral oil is usually not used during pregnancy because of possible unwanted effects on the mother or infant. Mineral oil may interfere with the absorption of nutrients and vitamins in the mother. Also, if taken for a long time during pregnancy, mineral oil may cause severe bleeding in the newborn infant.
• Stimulant laxatives may cause unwanted effects in the expectant mother if improperly used. Castor oil in particular should not be used as it may cause contractions of the womb.

Laxatives containing cascara and danthron may pass into the breast milk. Although the amount of laxative in the milk is generally thought to be too small to cause problems in the baby, your doctor should be told if you plan to use such laxatives. Some reports claim that diarrhea has been caused in the infant.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

• Amantadine
• Amifampridine
• Amisulpride
• Atropine
• Belladonna
• Belladonna Alkaloids
• Benztropine
• Bepridil
• Biperiden
• Burosumab-twza
• Cisapride
• Clidinium
• Darifenacin
• Dicyclomine
• Dronedarone
• Eplerenone
• Fesoterodine
• Glycopyrrolate
• Hyoscyamine
• Mesoridazine
• Methscopolamine
• Oxybutynin
• Pimozide
• Piperaquine
• Procyclidine
• Saquinavir
• Scopolamine
• Solifenacin
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tolterodine
• Trihexyphenidyl
• Trospium
• Ziprasidone

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acalabrutinib
• Alacepril
• Alfuzosin
• Amiloride
• Amiodarone
• Amitriptyline
• Amoxapine
• Amphetamine
• Amygdalin
• Anagrelide
• Apomorphine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asenapine
• Astemizole
• Azathioprine
• Azithromycin
• Bedaquiline
• Benazepril
• Benzphetamine
• Bictegravir
• Bisacodyl
• Buprenorphine
• Buserelin
• Canrenoate
• Captopril
• Chloroquine
• Chlorpromazine
• Cilazapril
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clomipramine
• Clozapine
• Crizotinib
• Cyclobenzaprine
• Cyclosporine
• Dabrafenib
• Dasatinib
• Deferoxamine
• Degarelix
• Delamanid
• Delapril
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dextroamphetamine
• Digoxin
• Dimercaprol
• Disopyramide
• Dofetilide
• Dolasetron
• Dolutegravir
• Domperidone
• Donepezil
• Droperidol
• Efavirenz
• Eltrombopag
• Elvitegravir
• Enalaprilat
• Enalapril Maleate
• Encorafenib
• Erythromycin
• Escitalopram
• Fingolimod
• Flecainide
• Fluconazole
• Fluoxetine
• Foscarnet
• Fosinopril
• Gatifloxacin
• Gefitinib
• Gemifloxacin
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hyaluronidase
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Iloperidone
• Imidapril
• Imipramine
• Indomethacin
• Inotuzumab Ozogamicin
• Ivabradine
• Ivosidenib
• Ketoconazole
• Lamivudine
• Lapatinib
• Ledipasvir
• Leuprolide
• Levofloxacin
• Levomethadyl
• Licorice
• Lisdexamfetamine
• Lisinopril
• Lofexidine
• Lopinavir
• Lumefantrine
• Macimorelin
• Mefenamic Acid
• Mefloquine
• Memantine
• Mercaptopurine
• Methadone
• Methamphetamine
• Metronidazole
• Mifepristone
• Moexipril
• Moxifloxacin
• Mycophenolate Mofetil
• Mycophenolic Acid
• Nafarelin
• Neratinib
• Nilotinib
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Ondansetron
• Osimertinib
• Paliperidone
• Panobinostat
• Pasireotide
• Pazopanib
• Pentopril
• Perindopril
• Phenytoin
• Pimavanserin
• Piperaquine
• Pitolisant
• Polyethylene Glycol 3350
• Posaconazole
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinapril
• Quinidine
• Quinine
• Raltegravir
• Ramipril
• Ranolazine
• Ribociclib
• Rilpivirine
• Salmeterol
• Senna
• Sertraline
• Sevoflurane
• Sodium Picosulfate
• Sodium Polystyrene Sulfonate
• Solifenacin
• Sorafenib
• Sotalol
• Spirapril
• Spironolactone
• St John's Wort
• Sulpiride
• Sunitinib
• Tacrolimus
• Telavancin
• Telithromycin
• Temocapril
• Tetrabenazine
• Tizanidine
• Toremifene
• Trandolapril
• Trazodone
• Triamterene
• Trifluoperazine
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Vinflunine
• Vismodegib
• Voriconazole
• Zofenopril
• Zuclopenthixol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using medicines in this class with any of the following is not recommended. Your doctor may decide not to treat you with a medication in this class, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Appendicitis (or signs of) or
• Rectal bleeding of unknown cause—These conditions need immediate attention by a doctor.

• Colostomy or
• Intestinal blockage or
• Ileostomy—The use of laxatives may create other problems if these conditions are present.

• Type 2 diabetes mellitus—Diabetic patients should be careful since some laxatives contain large amounts of sugars, such as dextrose, galactose, and/or sucrose.

• Heart disease or
• High blood pressure—Some laxatives contain large amounts of sodium, which may make these conditions worse.

• Kidney disease—Magnesium and potassium (contained in some laxatives) may build up in the body if kidney disease is present; a serious condition may develop.

• Swallowing difficulty—Mineral oil should not be used since it may get into the lungs by accident and cause pneumonia; also, bulk-forming laxatives may get lodged in the esophagus of patients who have difficulty in swallowing.

Do not take any type of laxative:

• if you have signs of appendicitis or inflamed bowel (such as stomach or lower abdominal pain, cramping, bloating, soreness, nausea, or vomiting). Instead, check with your doctor as soon as possible.
• for more than 1 week unless your doctor has prescribed or ordered a special schedule for you. This is true even when you have had no results from the laxative.
• within 2 hours of taking other medicine because the desired effect of the other medicine may be reduced.
• if you do not need it, as for the common cold, "to clean out your system" or as a "tonic to make you feel better."
• if you miss a bowel movement for a day or two.
• if you develop a skin rash
• while taking a laxative or if you had a rash the last time you took it. Instead, check with your doctor.

If you notice a sudden change in bowel habits or function that lasts longer than 2 weeks, or that keeps returning off and on, check with your doctor before using a laxative. This will allow the cause of your problem to be determined before it may become more serious.

The "laxative habit"—Laxative products are overused by many people. Such a practice often leads to dependence on the laxative action to produce a bowel movement. In severe cases, overuse of some laxatives has caused damage to the nerves, muscles, and tissues of the intestines and bowel. If you have any questions about the use of laxatives, check with your health care professional.

Many laxatives often contain large amounts of sugars, carbohydrates, and sodium. If you are on a low-sugar, low-caloric, or low-sodium diet, check with your health care professional before using a laxative.

For patients taking laxatives containing mineral oil:

• Mineral oil should not be taken often or for long periods of time because:
  • gradual build-up in body tissues may create additional problems.
• the use of mineral oil may interfere with the body's ability to absorb certain food nutrients and vitamins A, D, E, and K.

Large doses of mineral oil may cause some leakage from the rectum. The use of absorbent pads or a decrease in dose may be necessary to prevent the soiling of clothing.

Do not take mineral oil within 2 hours of a stool softener (emollient laxative). The stool softener may increase the amount of mineral oil absorbed.

For patients taking laxatives containing a stimulant ingredient:

• Stimulant laxatives are most often associated with:
  • overuse and the laxative habit.
  • skin rashes.
  • intestinal cramping after dosing (especially if taken on an empty stomach).
  • potassium loss.