Enskyce
Enskyce is a birth control pill for preventing pregnancy. This combined oral contraceptive (COC) has two hormones in it: desogestrel (a progestin) and ethinyl estradiol (an estrogen). It comes in 28-day blister packs with 21 active tablets and 7 inactive tablets. It's monophasic, since all the active tablets have the same amount of hormones in them. The usual dosage is 1 tablet by mouth every day. Some side effects are nausea, breast tenderness, and headaches.
Enskyce is a generic of the discontinued brand name Desogen. Other generics include Apri, Isibloom, Kalliga, Juleber, and Reclipsen.
What is Enskyce?
What is Enskyce used for?
- To prevent pregnancy
How Enskyce works
Enskyce is a combined contraceptive that contains two hormones: desogestrel (a progestin) and ethinyl estradiol (an estrogen). The hormones work together to prevent pregnancy in a few ways.
- It stops ovulation (the release of an egg from the ovary).
- It changes cervical mucus to block sperm from moving through.
- It changes the lining of the uterus (womb) to create an unfriendly environment for the fertilized egg.
Drug facts
| Common Brands | Enskyce |
|---|---|
| Drug Class | Estrogen / Progestin combined contraceptive |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
More on Enskyce essentials
Side effects of Enskyce
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Nausea
- Vomiting
- Stomach cramps
- Bloating
- Spotting or breakthrough bleeding
- Change in menstrual flow
- Breast tenderness
- Change in weight (up or down)
- Headache
Less Common Side Effects
- Spotty darkening of skin
- Having trouble wearing contact lenses
- Change in sex drive
- Acne
- Change in appetite
- Higher blood pressure
- Depression
- Yeast infection
Enskyce serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Heart attack: chest pain, stomach discomfort, sweating, nausea, dizziness
- Stroke: sudden numbness or weakness in one arm or leg, numbness or weakness on one side of the face, severe headache, confusion, trouble seeing, trouble walking
- Deep vein thrombosis (blood clot in the leg): leg cramp, swelling, or pain; muscle tightness
- Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
- Serious liver problems: yellowing of the skin or the whites of the eyes, tiredness, stomach pain
More on Enskyce side effects
The following Enskyce side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
Absent, missed, or irregular menstrual periods
change in vision
changes in skin color
chest pain or discomfort
chills
clay-colored stools
dark urine
dizziness, lightheadedness, fainting
hives or welts
itching skin or rash
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
pain or discomfort in the arms, jaw, back, or neck
pain, tenderness, or swelling of the foot or leg
pains in the chest, groin, or legs, especially in the calves of the legs
severe headaches of sudden onset
slow or fast heartbeat
stomach pain
sudden loss of coordination or slurred speech
sudden troubled breathing
sweating
unusual tiredness or weakness
vomiting
vomiting of blood
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
blotchy spots on the exposed skin
breast enlargement or tenderness
feeling sad or empty
irritability
itching of the vagina or outside the genitals
loss of interest or pleasure
pain during sexual intercourse
thick, white curd-like vaginal discharge without odor or with mild odor
trouble wearing contact lenses
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Enskyce
Pros
- Taken once a day
- Works well to prevent pregnancy (93% successful at preventing pregnancy with typical use)
- Blister packs have easy-to-follow instructions written on them
- Can make your menstrual cycle more regular
Cons
- Need to take at the same time every day for it to work as best as it can to prevent pregnancy
- Might cause breakthrough bleeding when you first start using it
- Doesn't protect against sexually transmitted diseases (STDs)
- Not a good option for people over 35 who smoke
Pharmacist tips for Enskyce
- Take Enskyce at the same time every day to help make it part of your daily routine. You can also set an alarm to help you remember to take it. Forgetting to take your pill can raise your chance of getting pregnant. If you miss a dose, read the instructions that came with your prescription or ask your prescriber about what to do.
- It's normal to have spotting (light bleeding outside of your period) after starting Enskyce. It's also common to have an upset stomach. These side effects should get better over time. But if they don't, talk to your healthcare team.
- If you vomit or have diarrhea, Enskyce might not work as well to prevent pregnancy. Use a back-up method of birth control until you can follow up with a healthcare professional (HCP).
- If you've been taking Enskyce as instructed and you've missed two periods in a row or feel like you might be pregnant, consider taking a pregnancy test, especially if you had sex recently. Taking Enskyce early in pregnancy doesn't usually raise the risk of birth defects. But you won't need to take birth control anymore once you're pregnant.
- It's not recommended to take Enskyce while breastfeeding. It can lower the amount of breast milk you can make. If you're breastfeeding, ask your HCP about other birth control options.
- After you stop taking Enskyce, it can take some time before you can get pregnant. It's recommended to wait until you have regular menstrual cycles again after stopping Enskyce before you try to get pregnant. If you want to stop taking Enskyce and become pregnant, talk to your HCP.
- Be sure to use condoms while having sex, even if you're taking Enskyce. Enskyce doesn't protect you and your partner against sexually transmitted diseases (STDs).
- Your Enskyce prescription is only meant for you. Don't share it with anyone who wants to take birth control. Their HCP should talk to them to make sure they get a safe option.
How to start Enskyce:
- There are two different options on how to start Enskyce: Day 1 Start and the Sunday Start methods. For both methods, start with the first active pill in the pack. Talk to your HCP about the best way for you to start Enskyce.
- For the Day 1 Start: Begin taking Enskyce during the first 24 hours of your period. You don't need to use a back-up method of birth control if you have sex.
- For the Sunday Start method: Begin taking Enskyce on the Sunday after your period starts (even if you're still bleeding). Use another form of birth control (e.g., condom, spermicide) along with Enskyce if you have sex during the first 7 days.
More on Enskyce tips
Risks and warnings for Enskyce
Enskyce can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Cigarette smoking and the risk for serious heart problems
- Risk factors: Over 35 years old and smoke cigarettes
If you smoke cigarettes, using combined oral contraceptives (COCs) like Enskyce raises your risk of serious health problems. These include strokes, heart attacks, and blood clots. People 35 years and older who smoke are at even higher risk. It's also even higher with the more cigarettes smoked. If you smoke, talk to your healthcare professional (HCP) about safer birth control options.
Risk for blood clots and related complications (e.g., heart attack, stroke)
- Risk factors: Over 35 years old and smoke | Over 40 years old who don't smoke | Recent surgery with a long period of bedrest | Starting Enskyce less than a month after childbirth | People identified as obese | High blood pressure | High cholesterol | Diabetes | Higher dose of estrogen
Enskyce raises your risk of blood clots, though the overall risk is quite low. These clots can occur anywhere in your body. This can include your legs (a deep vein thrombosis or DVT) or lungs (a pulmonary embolism or PE). Clots can also happen near the brain (raising your risk for a stroke) or heart (raising your risk for a heart attack).
Get emergency help right away if you have any signs of a blood clot or its complications.
- Brain (stroke): weakness or numbness on one side of the body, weakness or numbness on one side of the face, trouble speaking, blurred vision, dizziness, loss of balance, trouble walking, or confusion
- Eyes: trouble seeing, bulging eye, double vision, or vision loss
- Heart (heart attack): chest pain, sweating, nausea, or dizziness
- Lungs (PE): trouble breathing, chest pain, or cough
- Legs (DVT): cramps, swelling, pain, or muscle tightness
If you have a surgery planned, tell your HCP that you're taking Enskyce well beforehand. They might tell you to stop Enskyce 4 weeks before until 2 weeks after your surgery. This helps lower your risk of blood clots.
Risk of breast and cervical cancer
- Risk factors: History of breast cancer | Taking COCs for a long time
Study results are mixed, but there's a possibility that Enskyce and other COCs can raise your risk for breast and cervical cancer.
Don't take Enskyce if you have breast cancer. Some types of breast cancer grow faster when there's estrogen around. Estrogen is one of the hormones in this birth control pill.
To help with early breast cancer detection, you can do monthly breast self-checks at home and yearly breast exams with your HCP. Call your HCP if you notice any abnormal changes or feel lumps, pain, or swelling in your breasts.
Also get medical help right away if you have abnormal vaginal bleeding, discharge, or pain during sex. These could be signs of cervical cancer.
Liver problems
- Risk factors: History of liver problems | Taking certain hepatitis C combination medications
Don't take Enskyce if you have liver problems. Although rare, COCs like Enskyce can raise the risk of liver problems, like liver damage or benign liver tumors. This risk was higher with older COCs that had a higher estrogen dose (up to 50 mcg). The risk isn't as high with Enskyce because it contains 30 mcg of estrogen.
To be safe, it's important to still know about this risk. Call your HCP right away if you have tiredness, stomach pain, loss of appetite, or yellowing of the skin or whites of the eyes. These can be signs of liver problems.
High blood sugar, high cholesterol levels, and high triglyceride levels
- Risk factors: Prediabetes or diabetes | Personal or family history of high triglycerides
COCs like Enskyce might raise your blood sugar levels. If you have prediabetes or diabetes, the risk that your blood sugar can go up is higher. This is because COCs make it harder for your body to break down sugar. Let your HCP know if you have any changes in your blood sugar.
Some people who take COCs also might have higher cholesterol levels and triglyceride (fat) levels. In particular, high triglyceride levels might lead to a higher risk of pancreatitis (inflammation of the pancreas).
Talk to your HCP if you have a history of high blood sugar or high cholesterol. They can make sure Enskyce is safe for you. Be sure to get any blood work done so your HCP can monitor any changes.
High blood pressure
- Risk factors: High blood pressure | Older age | Using COCs for a long time | Kidney problems
Enskyce and other COCs can raise your blood pressure. The risk might be higher as you get older and as you use COCs over a long time.
Your HCP might ask you to check your blood pressure regularly. Call your HCP if your blood pressure is higher than usual while you're taking this medication. They can help manage your blood pressure or find other birth control options for you. If you have uncontrolled high blood pressure, Enskyce might not be the best option for you.
Headache
Headaches are a common side effect of COCs like Enskyce. But if you have a new migraine, a migraine that's worse than normal, a new headache that keeps coming back, or a new headache that's severe, call your HCP so you can be checked out.
Irregular bleeding
Breakthrough bleeding and spotting are common side effects of hormonal birth control pills such as Enskyce. It's more likely to happen during the first 3 months of using Enskyce. Tell your prescriber if you have any vaginal bleeding outside of your period. Also let them know if your period has stopped completely. There are other reasons for irregular bleeding besides your birth control pills that your HCP can check out.
Depression
- Risk factors: History of depression
Let your care team know if you have symptoms of depression or worsening depression while taking Enskyce. In cases of serious depression, your HCP might tell you to stop taking this medication.
Interactions with other medications
Tell your prescriber or pharmacist about all your medications so they can make sure they're safe for you. Certain medications can interact with Enskyce. Some can make Enskyce get broken down faster in the body, making it work less well to prevent pregnancy. Some examples include carbamazepine (Tegretol) and phenytoin (Dilantin). Use a back-up method or other form of birth control while you're taking these medications until at least 28 days after stopping them. Other medications can raise the amount of Enskyce in your body and lead to more side effects.
If you have hepatitis C and need to take Viekira Pak (dasabuvir / ombitasvir / paritaprevir / ritonavir), let your HCP know right away that you're taking a COC. You'll need to stop Enskyce before starting Viekira Pak because taking them together can cause liver problems. You can start Enskyce again 2 weeks after you stop Viekira Pak.
More on Enskyce warnings
Enskyce dosage
Package| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 28 tablets of 0.15mg/0.03mg | 1 package | $15.13 | $15.13 |
Typical dosage for Enskyce
Enskyce comes in a 28-day pack. Take the birth control pill as instructed by your prescriber.
There are 21 active tablets that each contain 0.15 mg desogestrel and 30 mcg ethinyl estradiol. There are also 7 inactive (placebo) tablets that don't contain any active ingredients.
In general, the typical dose is 1 active tablet by mouth daily for 21 days, followed by 1 inactive tablet daily for the next 7 days. Repeat this dosing schedule for each pack.
Interactions between Enskyce and other drugs
More on Enskyce interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Dasabuvir
- Ombitasvir
- Paritaprevir
- Ritonavir
- Tranexamic Acid
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amifampridine
- Amoxicillin
- Ampicillin
- Amprenavir
- Anagrelide
- Apalutamide
- Aprepitant
- Armodafinil
- Artemether
- Bacampicillin
- Betamethasone
- Bexarotene
- Boceprevir
- Bosentan
- Brigatinib
- Bupropion
- Carbamazepine
- Carbenicillin
- Cefaclor
- Cefadroxil
- Cefdinir
- Cefditoren
- Cefixime
- Cefpodoxime
- Cefprozil
- Ceftazidime
- Ceftibuten
- Cefuroxime
- Cenobamate
- Ceritinib
- Clavulanic Acid
- Clobazam
- Cloxacillin
- Colesevelam
- Cyclacillin
- Cyclosporine
- Dabrafenib
- Darunavir
- Dexamethasone
- Dicloxacillin
- Donepezil
- Doxycycline
- Efavirenz
- Elagolix
- Elvitegravir
- Encorafenib
- Enzalutamide
- Eslicarbazepine Acetate
- Etravirine
- Fosamprenavir
- Fosaprepitant
- Fosphenytoin
- Fostemsavir
- Glecaprevir
- Griseofulvin
- Guar Gum
- Isotretinoin
- Ivosidenib
- Lesinurad
- Lixisenatide
- Lorlatinib
- Lumacaftor
- Minocycline
- Mitotane
- Modafinil
- Mycophenolate Mofetil
- Mycophenolic Acid
- Nafcillin
- Nelfinavir
- Nevirapine
- Octreotide
- Oxacillin
- Oxcarbazepine
- Oxytetracycline
- Paclitaxel
- Paclitaxel Protein-Bound
- Penicillin G
- Penicillin G Procaine
- Penicillin V
- Phenobarbital
- Phenylbutazone
- Phenytoin
- Pibrentasvir
- Piperaquine
- Pitolisant
- Prednisone
- Primidone
- Red Clover
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Rufinamide
- Secobarbital
- St John's Wort
- Sugammadex
- Sultamicillin
- Tazemetostat
- Telaprevir
- Tetracycline
- Theophylline
- Ticarcillin
- Tigecycline
- Tizanidine
- Topiramate
- Troglitazone
- Ulipristal
- Valproic Acid
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amitriptyline
- Atazanavir
- Clomipramine
- Diazepam
- Doxepin
- Eslicarbazepine Acetate
- Etoricoxib
- Ginseng
- Imipramine
- Lamotrigine
- Levothyroxine
- Licorice
- Lorazepam
- Parecoxib
- Prednisolone
- Roflumilast
- Selegiline
- Temazepam
- Tipranavir
- Triazolam
- Troleandomycin
- Valdecoxib
- Voriconazole
- Warfarin
How much does Enskyce cost?
$12.96
Enskyce contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Enskyce will not be safe for you to take.
- Smoking over the age of 35
- Medical conditions that raise the risk for blood clots
- Currently have or have had a blood clot (DVT or PE)
- Coronary artery disease (CAD)
- Problems with blood flow to the brain (e.g., stroke)
- Certain heart valve or heart rhythm problems
- Uncontrolled high blood pressure
- Diabetes with long-term complications
- Certain types of headaches
- Major surgery where you're on bedrest for a long time
- Undiagnosed abnormal vaginal bleeding
- Currently have or have a history of breast cancer
- Endometrial cancer (also called uterine cancer) or other estrogen-dependent cancer
- Currently have or have a history of jaundice (yellowing of the skin and whites of the eyes)
- Liver problems
- Liver tumor
- Currently pregnant
- Taking hepatitis C medication containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir
What are alternatives to Enskyce?
Enskyce images
