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Dacarbazine

Dacarbazine Side Effects

Allison Baxley, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Allison Baxley, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on October 31, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea
  • Vomiting
  • Poor appetite
  • Low white blood cell count
  • Low red blood cell count
  • Low platelets

Less Common Side Effects

  • Flu-like symptoms
  • Fever
  • Muscle aches
  • Hair loss
  • Flushing
  • Numbness in the face
  • Skin rash

Dacarbazine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious infection (from having low white blood cell counts): temperature of 100.4 degrees Fahrenheit or higher, with or without other symptoms like chills, cough, muscle aches, very fast heartbeat, or confusion
  • Low red blood cell counts or low platelets: severe tiredness, nosebleeds, unexplained bruising or bleeding, bleeding that's hard to stop
  • Liver problems: nausea, vomiting, tiredness, stomach pain or swelling, pale-colored stool, dark-colored urine, yellowing of the whites of the eyes or skin
  • Serious allergic reaction: sudden trouble breathing, tightness in the throat or chest, itchy rash, sudden confusion

Source: DailyMed

The following Dacarbazine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur:

More common

Redness, pain, or swelling at place of injection

Less common

Black, tarry stools

blood in urine or stools

cough or hoarseness, accompanied by fever or chills

fever or chills

lower back or side pain, accompanied by fever or chills

painful or difficult urination, accompanied by fever or chills

pinpoint red spots on skin

unusual bleeding or bruising

Rare

Shortness of breath

stomach pain

swelling of face

yellow eyes or skin

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Sores in mouth and on lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Loss of appetite

nausea or vomiting (should lessen after 1 or 2 days)

Less common

Feelings of uneasiness

flushing of face

muscle pain

numbness of face

This medicine may cause a temporary loss of hair in some people. After treatment with dacarbazine has ended, normal hair growth should return.

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Black, tarry stools

blood in urine or stools

cough or hoarseness, accompanied by fever or chills

fever or chills

lower back or side pain, accompanied by fever or chills

painful or difficult urination, accompanied by fever or chills

pinpoint red spots on skin

unusual bleeding or bruising

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison is a Board Certified Oncology Pharmacist with more than 12 years of clinical experience in oncology. After completing her residency, she accepted a position at the OU Health Stephenson Cancer Center and she has remained there ever since.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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