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Zyrtec-D vs. Phenylephrine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zyrtec-D (cetirizine/pseudoephedrine) and phenylephrine eye drops are used for different purposes and have distinct characteristics. Zyrtec-D is a combination of an antihistamine (cetirizine) and a decongestant (pseudoephedrine) that helps relieve seasonal allergies and nasal congestion. It's taken orally and is available over the counter. Zyrtec-D may cause trouble sleeping and a temporary rise in blood pressure. On the other hand, phenylephrine eye drops are used to dilate pupils for eye exams or procedures. This medication is an alpha-1 adrenergic receptor agonist and is available only by prescription. It can cause temporary eye discomfort, blurry vision, and sensitivity to light, and it may also raise blood pressure, especially in higher concentrations.

Zyrtec-D

(cetirizine / pseudoephedrine)

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phenylephrine eye drops

 

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Summary for Zyrtec-D

Over-the-counter

Zyrtec-D is a combination medication containing cetirizine (an antihistamine) and pseudoephedrine (a decongestant). It's taken by people ages 12 years and older to relieve allergy symptoms, like runny nose and nasal congestion. This medication comes as an extended-release tablet that's taken by mouth every 12 hours. Zyrtec-D is available as a brand-name and generic medication. Side effects can include trouble sleeping and dry mouth.

Indications for Zyrtec-D

Short-term relief of allergy symptoms in adults and children ages 12 years and older:

  • Itchy nose or throat
  • Sneezing
  • Itchy or watery eyes
  • Runny or stuffy nose
  • Sinus congestion or pressure

Pros and Cons for Zyrtec-D

Pros

  • Starts working within an hour
  • Easier to take a combination pill instead of two separate pills to treat congestion and other allergy symptoms
  • Available over the counter (behind the counter)

Cons

  • Might need to take twice daily
  • Tablets can't be crushed or chewed and there isn't a liquid version available
  • Not the safest choice if you have certain conditions, like heart problems and trouble urinating

Common Side Effects for Zyrtec-D

Warnings for Zyrtec-D

  • Fast heart rate and high blood pressure
  • Worsening of certain medical conditions
  • Accidentally taking too much medication

Summary for Phenylephrine

Prescription only

Phenylephrine eye drops are used to dilate (widen) pupils for eye exams or certain eye procedures. Side effects include temporary burning or stinging in the eye, blurry vision, and possibly raise your blood pressure. Let your provider know if your pregnant or breastfeeding because you might need to use a different medication.

Indications for Phenylephrine

  • Dilate (widen) pupils

Pros and Cons for Phenylephrine

Pros

  • Can be used in adults and children
  • Starts working quickly (within 15 minutes)
  • Available as a lower-cost generic medication

Cons

  • Can cause eye pain and stinging
  • Dilating effects can last for up to 7 hours (or longer)
  • The 10% strength can raise blood pressure in people with certain heart or thyroid problems

Common Side Effects for Phenylephrine

  • Temporary stinging or burning in your eye
  • Temporary blurry vision
  • Sensitivity to light

Warnings for Phenylephrine

  • For use in the eyes only
  • Heart problems
  • High blood pressure
  • Rebound pupil constriction

Prices with our coupons for Zyrtec-D vs. Phenylephrine

Price Card Drug Icon
Cetirizine/Pseudoephedrine24 tablets / 12 hour
$21.40-
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Price Card Drug Icon
Phenylephrine1 eye dropper / 2ml of 2.5%
$21.67$40.99
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